ChemicalBook > CAS DataBase List > AF12198

AF12198

Product Name
AF12198
CAS No.
185413-30-3
Chemical Name
AF12198
Synonyms
AF12198;AF12198（TFA）;Ac-FEWTPGWYQ（Aze）YALPL-NH2;AF12198, human type I interleukin receptor antagonist;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2;AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2;L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-
CBNumber
CB5268870
Molecular Formula
C96H123N19O22
Formula Weight
1895.12
MOL File
185413-30-3.mol
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AF12198 Property

Melting point:
>179°C (dec.)
Density 
1.353±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Very Slightly)
form 
solid
pka
4.44±0.10(Predicted)
color 
White to Off-White
Sequence
Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-{Aze}-Tyr-Ala-Leu-Pro-Leu-NH2
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1793
Product name
AF12198
Packaging
1
Price
$352
Updated
2021/12/16
Usbiological
Product number
254553
Product name
AF 12198
Packaging
1mg
Price
$631
Updated
2021/12/16
TRC
Product number
A355020
Product name
AF12198
Packaging
25mg
Price
$1760
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
67690
Product name
AF12198
Packaging
25mg
Price
$2320
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA109195
Product name
Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2
Packaging
500ug
Price
$775
Updated
2021/12/16
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AF12198 Chemical Properties,Usage,Production

Uses

AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders.

in vivo

AF12198 (intravenous infusion; 16 mg/kg; 30 min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4 h (32.6%), 12 h (50.1%) and 24 h (65.3%) after LPS[2].

Animal Model:Male Wistar rats[2]
Dosage:16?mg/kg
Administration:Intravenous infusion; 30?min before LPS intravenous injection
Result:Decreased pulmonary microvascular leakage in rats.

IC 50

IL-6; IL-8; IL1R1: 8 nM (IC50)

storage

Store at -20°C

AF12198 Preparation Products And Raw materials

Raw materials

Preparation Products

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AF12198 Suppliers

China 62 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 2 United States 11 Global 79
Creative Peptides
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info@creative-peptides.com
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inquiry@bocsci.com
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Abcam Limited
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United States Biological
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MedChemExpress
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185413-30-3, AF12198Related Search:

AF12198 2-Azetidinemethanamine AZETIDINE-2-CARBOXAMIDE

  • AF12198
  • AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-AZE-TYR-ALA-LEU-PRO-LEU-NH2
  • AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBONYL-TYR-ALA-LEU-PRO-LEU-NH2
  • AC-PHE-GLU-TRP-THR-PRO-GLY-TRP-TYR-GLN-L-AZETIDINE-2-CARBOXYLIC ACID-TYR-ALA-LEU-PRO-LEU-NH2
  • L-Leucinamide, N-acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-
  • Ac-FEWTPGWYQ（Aze）YALPL-NH2
  • AF12198（TFA）
  • AF12198, human type I interleukin receptor antagonist
  • 185413-30-3
  • C96H123N19O22