ChemicalBook > CAS DataBase List > rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate

rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate

Product Name
rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate
CAS No.
136310-66-2
Chemical Name
rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate
Synonyms
Tiotropium Impurity D;Tiotropium Impurity 30;Tiotropium EP Impurity D;Tiotropium Bromide EP Impurity D;Tiotropium Bromide Monohydrate Impurity D;Tiotropium Bromide Impurity 4(Tiotropium Bromide EP Impurity D);(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl α-hydroxy-α-2-thienyl-2-thiopheneacetate;rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate;2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl ester;(1R,3S,5S)-2'-hydroxy-2',2'-di(thiophen-2''-yl)acetic acid 8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl ester
CBNumber
CB52696174
Molecular Formula
C18H19NO3S2
Formula Weight
361.47
MOL File
136310-66-2.mol
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rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Property

Boiling point:
522.8±50.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
pka
10.33±0.29(Predicted)
form 
Solid
color 
Pale Orange to Brown
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
IM42883
Product name
(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl-2'-hydroxy-2',2'-di(thiophen-2''-yl)acetate
Packaging
1mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
X3281
Product name
TiotropiumBromideMonohydrateImpurityD
Packaging
5mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
IM42883
Product name
(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl-2'-hydroxy-2',2'-di(thiophen-2''-yl)acetate
Packaging
2mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
IM42883
Product name
(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl-2'-hydroxy-2',2'-di(thiophen-2''-yl)acetate
Packaging
5mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
IM42883
Product name
(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl-2'-hydroxy-2',2'-di(thiophen-2''-yl)acetate
Packaging
10mg
Price
$200
Updated
2021/12/16
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rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Chemical Properties,Usage,Production

Uses

(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-ylacetate is an impurity in the synthesis of Tiotropium Bromide (T444850), a muscarinic receptor antagonist. Bronchodilator.

rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate Suppliers

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136310-66-2, rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetateRelated Search:

Ethanedioic acid,1-methyl ester, potassium salt (1:1) Scopine Methobromide (1α,2β,4β,5α)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7α-ol Tiotropium bromide Tiotropium-D6 Bromide trans-trans-4,4'-iminodimethylenedi(cyclohexanecarboxylic acid) Torsemide Related Compound 1 DesvancosaMinyl VancoMycin Vancomycin hydrochloride Teloidine 2,3-Dibromothiophene Tiotropium bromide Impurity 16 BIS(2-THIENYL) KETONE Methyl 2,2-dithienylglycolate D-Tyrosine N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine TiotropiuM BroMide IMpurity I 2-HYDROXY-2,2-BIS(2-THIENYL) ACETIC ACID

  • rel-(1R,3S,5S)-8-Methyl-8-azabicyclo[3,2,1]oct-6-en-yl-2-hydroxy-2,2-dithiophen-2-yl acetate
  • Tiotropium EP Impurity D
  • Tiotropium Bromide Impurity 4(Tiotropium Bromide EP Impurity D)
  • (1R,3S,5S)-2'-hydroxy-2',2'-di(thiophen-2''-yl)acetic acid 8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl ester
  • Tiotropium Bromide EP Impurity D
  • 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl ester
  • Tiotropium Impurity 30
  • Tiotropium Impurity D
  • (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-6-en-3-yl α-hydroxy-α-2-thienyl-2-thiopheneacetate
  • Tiotropium Bromide Monohydrate Impurity D
  • 136310-66-2
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds