Methyl 2,2-dithienylglycolate
- Product Name
- Methyl 2,2-dithienylglycolate
- CAS No.
- 26447-85-8
- Chemical Name
- Methyl 2,2-dithienylglycolate
- Synonyms
- Compound PDK0140;Aclidinium Impurity 5;2,2-dithienylglycolate;Tiotropium EP Impurity E;Aclidinium bromide impurity;China 2 2-dithienylglycolate;TiotropiuM BroMide IMpurity E;Methyl di(2-thienyl)glycolate;METHYL 2,2-DITHIENYL GLYCOLATE;Tiotropium Bromide BP Impurity E
- CBNumber
- CB0120838
- Molecular Formula
- C11H10O3S2
- Formula Weight
- 254.32
- MOL File
- 26447-85-8.mol
Methyl 2,2-dithienylglycolate Property
- Melting point:
- 93-95°C
- Boiling point:
- 406.5±40.0 °C(Predicted)
- Density
- 1.392±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 10.43±0.29(Predicted)
- color
- White to Light Brown
- InChI
- InChI=1S/C11H10O3S2/c1-14-10(12)11(13,8-4-2-6-15-8)9-5-3-7-16-9/h2-7,13H,1H3
- InChIKey
- SYHWYWHVEQQDMO-UHFFFAOYSA-N
- SMILES
- C(C1SC=CC=1)(C1SC=CC=1)(O)C(=O)OC
- CAS DataBase Reference
- 26447-85-8(CAS DataBase Reference)
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M303765
- Product name
- MethylDi(2-thienylglycolate)
- Packaging
- 1g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- 282400
- Product name
- Methyl 2,2-dithienylglycolate
- Packaging
- 50g
- Price
- $531
- Updated
- 2021/12/16
- Product number
- CS-W020702
- Product name
- 2-Thiopheneaceticacid,α-hydroxy-α-2-thienyl-,methylester
- Purity
- 99.98%
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 073138
- Product name
- Methyl 2,2-dithienylglycolate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $23
- Updated
- 2021/12/16
- Product number
- CS-W020702
- Product name
- 2-Thiopheneaceticacid,α-hydroxy-α-2-thienyl-,methylester
- Purity
- 99.98%
- Packaging
- 10g
- Price
- $29
- Updated
- 2021/12/16
Methyl 2,2-dithienylglycolate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Methyl Di(2-thienylglycolate) (Tiotropium EP Impurity E) is an intermediate in the production of Tiotropium Bromide, a long-acting bronchodilator.
Synthesis
553-90-2
26447-85-8
Under nitrogen protection, 2-bromothiophene (9.68 mL, 0.1 mol) was slowly added dropwise to a stirred mixture of magnesium scrapings (2.7 g, 0.11 mol) and ether (100 mL), keeping the reaction temperature at 0 °C. Subsequently, the reaction mixture was warmed up to 35 °C with continuous stirring. Next, a solution of dimethyl oxalate (5.9 g, 0.05 mol) in ether (150 mL) was slowly added dropwise over a period of 3 hours. After the dropwise addition was completed, the reaction mixture was heated to reflux (45 °C) and maintained for 45 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and 1.25 M sulfuric acid (150 mL) was added. After stirring for 1 h at room temperature, the organic layer was separated and washed sequentially with dilute aqueous sodium bicarbonate (100 mL) and water (100 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting solid residue was recrystallized with carbon tetrachloride (1 g / 3 mL) to afford methyl 2,2-dithienyl ethanoate (7.68 g, 30 mmol, 60% yield).
References
[1] Patent: US2004/242622, 2004, A1. Location in patent: Page 29
Methyl 2,2-dithienylglycolate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2,2-dithienylglycolate manufacturers
- Product
- Methyl 2,2-dithienylglycolate 26447-85-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- Methyl di(2-thienyl) glycolate 26447-85-8
- Price
- US $300.00-7500.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- 5MT per month
- Release date
- 2020-04-01
- Product
- Methyl 2,2-dithienylglycolate 26447-85-8
- Price
- US $60.00-600.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-07