Nexturastat A

ChemicalBook > CAS DataBase List > Nexturastat A

Product Name: Nexturastat A
CAS No.: 1403783-31-2
Chemical Name: Nexturastat A
Synonyms: CS-1289;Nexturastat A;Nextunastat A;Nexturastat A, >97%;Nexturastat A, >=98%;Nexturastat A (AG-CR1-3901);4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE;4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide;4-[[Butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxybenzamide;Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
CBNumber: CB52715657
Molecular Formula: C19H23N3O3
Formula Weight: 341.4
MOL File: 1403783-31-2.mol

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Nexturastat A Property

Density: 1.228±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥9.3 mg/mL in EtOH
form: solid
pka: 8.95±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16874
Product name: Nexturastat A
Purity: ≥95%
Packaging: 500μg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 16874
Product name: Nexturastat A
Purity: ≥95%
Packaging: 1mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16874
Product name: Nexturastat A
Purity: ≥95%
Packaging: 5mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 16874
Product name: Nexturastat A
Purity: ≥95%
Packaging: 10mg
Price: $834
Updated: 2024/03/01

TRC

Product number: N391500
Product name: NexturastatA
Packaging: 25mg
Price: $1760
Updated: 2021/12/16

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Nexturastat A Chemical Properties,Usage,Production

Uses

Nexturastat A is a potent and selective histone deacetylase 6 (HDAC6) inhibitor that shows potential antiproliferative effects against melanoma cells.

Biological Activity

nexturastat a is a selective inhibitor of histone deacetylase 6 (hdac6) with ic50 value of 5.2 nm [1].nexturastat a is a hdac inhibitor. it was developed by structural modification of aryl urea hdacis. the inhibitory activity of nexturastat a is most potent against hdac6 with ic50 value of 5.2 nm. besides that, nexturastat a also shows inhibition of other hdacs with ic50 values of 3.02, 6.92, 6.68, 9.39, 11.7, 4.46, 0.954, 6.72, 7.57 and 5.14 μm for hdac1, 2, 3, 4, 5, 7, 8, 9, 10 and 11, respectively. nexturastat a has been shown to suppress cell proliferation and promote apoptosis in b16 murine melanoma cells [1, 2].

target

HDAC6

References

[1] kalin j h, bergman j a. development and therapeutic implications of selective histone deacetylase 6 inhibitors. journal of medicinal chemistry, 2013, 56(16): 6297-6313.
[2] zhang l, han y, jiang q, et al. trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy. medicinal research reviews, 2014.

Nexturastat A Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nexturastat A manufacturers

Career Henan Chemical Co

Product: 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE 1403783-31-2
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 98%
Supply Ability: 10kg
Release date: 2019-09-04

1403783-31-2, Nexturastat ARelated Search:

ACY-1215 Selumetinib Mocetinostat (MGCD0103) 4SC-201 Tubacin Entinostat

Nexturastat A, >=98%

4-[[Butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxybenzamide

Nexturastat A

4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE

Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-

Nexturastat A 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE

Nexturastat A Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-

4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide

CS-1289

Nexturastat A, >97%

Nextunastat A

Nexturastat A (AG-CR1-3901)

1403783-31-2

Inhibitors