ChemicalBook > CAS DataBase List > Nexturastat A

Nexturastat A

Product Name
Nexturastat A
CAS No.
1403783-31-2
Chemical Name
Nexturastat A
Synonyms
CS-1289;Nexturastat A;Nextunastat A;Nexturastat A, >97%;Nexturastat A, >=98%;Nexturastat A (AG-CR1-3901);4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE;4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide;4-[[Butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxybenzamide;Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
CBNumber
CB52715657
Molecular Formula
C19H23N3O3
Formula Weight
341.4
MOL File
1403783-31-2.mol
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Nexturastat A Property

Density 
1.228±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥9.3 mg/mL in EtOH
form 
solid
pka
8.95±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16874
Product name
Nexturastat A
Purity
≥95%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
16874
Product name
Nexturastat A
Purity
≥95%
Packaging
1mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
16874
Product name
Nexturastat A
Purity
≥95%
Packaging
5mg
Price
$477
Updated
2024/03/01
Cayman Chemical
Product number
16874
Product name
Nexturastat A
Purity
≥95%
Packaging
10mg
Price
$834
Updated
2024/03/01
TRC
Product number
N391500
Product name
NexturastatA
Packaging
25mg
Price
$1760
Updated
2021/12/16
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Nexturastat A Chemical Properties,Usage,Production

Uses

Nexturastat A is a potent and selective histone deacetylase 6 (HDAC6) inhibitor that shows potential antiproliferative effects against melanoma cells.

Biological Activity

nexturastat a is a selective inhibitor of histone deacetylase 6 (hdac6) with ic50 value of 5.2 nm [1].nexturastat a is a hdac inhibitor. it was developed by structural modification of aryl urea hdacis. the inhibitory activity of nexturastat a is most potent against hdac6 with ic50 value of 5.2 nm. besides that, nexturastat a also shows inhibition of other hdacs with ic50 values of 3.02, 6.92, 6.68, 9.39, 11.7, 4.46, 0.954, 6.72, 7.57 and 5.14 μm for hdac1, 2, 3, 4, 5, 7, 8, 9, 10 and 11, respectively. nexturastat a has been shown to suppress cell proliferation and promote apoptosis in b16 murine melanoma cells [1, 2].

target

HDAC6

References

[1] kalin j h, bergman j a. development and therapeutic implications of selective histone deacetylase 6 inhibitors. journal of medicinal chemistry, 2013, 56(16): 6297-6313.
[2] zhang l, han y, jiang q, et al. trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy. medicinal research reviews, 2014.

Nexturastat A Preparation Products And Raw materials

Raw materials

Preparation Products

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Nexturastat A Suppliers

China 79 The Netherlands 1 United States 15 Global 95
Angel Pharmatech, Ltd.
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View Lastest Price from Nexturastat A manufacturers

Career Henan Chemical Co
Product
4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE 1403783-31-2
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
98%
Supply Ability
10kg
Release date
2019-09-04

1403783-31-2, Nexturastat ARelated Search:

ACY-1215 Selumetinib Mocetinostat (MGCD0103) 4SC-201 Tubacin Entinostat

  • Nexturastat A, >=98%
  • 4-[[Butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxybenzamide
  • Nexturastat A
  • 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE
  • Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
  • Nexturastat A 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE
  • Nexturastat A Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
  • 4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
  • CS-1289
  • Nexturastat A, >97%
  • Nextunastat A
  • Nexturastat A (AG-CR1-3901)
  • 1403783-31-2
  • Inhibitors