MF 438
- Product Name
- MF 438
- CAS No.
- 921605-87-0
- Chemical Name
- MF 438
- Synonyms
- MF 438;MF-438, 10 mM in DMSO;Stearoyl-CoA Desaturase (SCD),inhibit,MF438,MF 438,MF-438,Inhibitor;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine;2-methyl-5-[6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]pyridazin-3-yl]-1,3,4-thiadiazole;Pyridazine, 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-;3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine(MF-438)
- CBNumber
- CB52716285
- Molecular Formula
- C19H18F3N5OS
- Formula Weight
- 421.44
- MOL File
- 921605-87-0.mol
MF 438 Property
- Boiling point:
- 614.5±65.0 °C(Predicted)
- Density
- 1.365±0.06 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 5 mg/ml) or in Ethanol (up to 2 mg/ml with warming).
- form
- solid
- pka
- 2.29±0.10(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- CS-0009306
- Product name
- MF-438
- Purity
- 99.92%
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0009306
- Product name
- MF-438
- Purity
- 99.92%
- Packaging
- 10mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- CS-0009306
- Product name
- MF-438
- Purity
- 99.92%
- Packaging
- 50mg
- Price
- $1150
- Updated
- 2021/12/16
- Product number
- CS-0009306
- Product name
- MF-438
- Purity
- 99.92%
- Packaging
- 100mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- 020466
- Product name
- MF-438
- Packaging
- 003
- Price
- $1800
- Updated
- 2021/12/16
MF 438 Chemical Properties,Usage,Production
Description
MF-438 (921605-87-0) is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) – IC50?= 2.3 nM.1?MF-438 was potent in an?in vivo?mouse liver PD assay (ED50?between 1 and 3 mg/kg).1?Cancer initiating cells (CSC-like) were shown to be much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2?MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
Uses
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 of 2.3 nM for rSCD1[1].
in vivo
MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model[1].
References
[1] SERGE LÉGER. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 20 2: Pages 499-502. DOI:10.1016/j.bmcl.2009.11.111
[2] A NOTO. Stearoyl-CoA desaturase-1 is a key factor for lung cancer-initiating cells[J]. Cell Death & Disease, 2013, 4 12: e947-e947. DOI:10.1038/cddis.2013.444
[3] N. RODRIGUEZ-PEREZ. Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma[J]. Allergy, 2017, 72 11: 1744-1752. DOI:10.1111/all.13180
MF 438 Preparation Products And Raw materials
Raw materials
Preparation Products
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