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Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-

Product Name
Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-
CAS No.
330792-69-3
Chemical Name
Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-
Synonyms
2-(Methoxy(4-phenoxyphenyl)Methylene)Malononitrile;Triamide impurity;Zanubrutinib Impurity 5;Zanubrutinib dimer impurity;Zanubrutinib Related Compound 3;1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene;2-(Methoxy(4- phenoxyphenyl)Methylene)Malononitri;1,1-dicyano-2-Methoxy-2-(4-Phenoxyphenyl)Ethylene;Methoxy(4phenoxyphenyl)methyli dene]propanedinitrile;2-[Methoxy(4-phenoxyphenyl)methylene]propanedinitrile
CBNumber
CB52716346
Molecular Formula
C17H12N2O2
Formula Weight
276.29
MOL File
330792-69-3.mol
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Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Property

Boiling point:
471.1±45.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C17H12N2O2/c1-20-17(14(11-18)12-19)13-7-9-16(10-8-13)21-15-5-3-2-4-6-15/h2-10H,1H3
InChIKey
IRVRZQLHMPWLLY-UHFFFAOYSA-N
SMILES
C(#N)/C(=C(/OC)\C1=CC=C(OC2=CC=CC=C2)C=C1)/C#N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-M2595
Product name
Propanedinitrile,2-[methoxy(4-phenoxyphenyl)methylene]-
Purity
99.89%
Packaging
5g
Price
$184
Updated
2021/12/16
AK Scientific
Product number
2556DA
Product name
2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile
Packaging
5g
Price
$269
Updated
2021/12/16
ChemScene
Product number
CS-M2595
Product name
Propanedinitrile,2-[methoxy(4-phenoxyphenyl)methylene]-
Purity
99.89%
Packaging
10g
Price
$278
Updated
2021/12/16
AK Scientific
Product number
2556DA
Product name
2-(Methoxy(4-phenoxyphenyl)methylene)malononitrile
Packaging
10g
Price
$404
Updated
2021/12/16
ChemScene
Product number
CS-M2595
Product name
Propanedinitrile,2-[methoxy(4-phenoxyphenyl)methylene]-
Purity
99.89%
Packaging
25g
Price
$511
Updated
2021/12/16
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Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Chemical Properties,Usage,Production

Synthesis

1623-95-6

77-78-1

109-77-3

330792-69-3

6.6 g of malononitrile (0.1 mol), 4.8 g of sodium hydride (0.2 mol, 80% dispersed in paraffin) and 100 mL of freshly treated anhydrous tetrahydrofuran were added to a three-neck flask. Under stirring conditions, 50 mL of tetrahydrofuran solution containing 4-phenoxybenzoyl chloride (23.2 g, 0.1 mol) was slowly added dropwise to the reaction system. After 2 hours of reaction at room temperature, 250 mL of 1 M dilute hydrochloric acid was added and stirring was continued for 30 minutes, followed by three extractions with ethyl acetate. The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated to give a solid. The solid was dissolved in a mixture of 150 mL of dioxane and 50 mL of saturated sodium bicarbonate solution, followed by the addition of dimethyl sulfate (37.8 g, 0.3 mol), and the reaction mixture was heated to 80 °C. The reaction was stirred at 90 °C for 3 h. The completion of the reaction was monitored by TLC. At the end of the reaction, 400 mL of deionized water was added and extracted three times with methyl tert-butyl ether. The organic phases were combined and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was recrystallized from methanol to give 17.6 g of white solid 2-(methoxy(4-phenoxyphenyl)methylene)malononitrile in 63.8% yield.

References

[1] Patent: US2016/264584, 2016, A1. Location in patent: Paragraph 0019

Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Suppliers

China 119 India 2 United Kingdom 1 United States 3 Global 125
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
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View Lastest Price from Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- manufacturers

Nanjing Fred Technology Co., Ltd
Product
2-[methoxy(4-phenoxyphenyl)-methylene]propanedinitrile 330792-69-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-28
Henan Fengda Chemical Co., Ltd
Product
Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- 330792-69-3
Price
US $10.00-3.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-29
Career Henan Chemical Co
Product
2-[Methoxy(4-phenoxyphenyl)methylene]propanedinitrile 330792-69-3
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-30

330792-69-3, Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-Related Search:

Vandetanib Vardenafil hydrochloride (1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (R)-Zanubrutinib Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)- tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- 1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim ent-Tadalafil cis-ent-Tadalafil cis-Tadalafil 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (S)-1-Boc-3-hydroxypiperidine Chloropretadalafil Trelagliptin succinate Tadalafil

  • 1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene
  • 2-[Methoxy(4-phenoxyphenyl)methylene]propanedinitrile
  • Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]-
  • 2-(Methoxy(4-phenoxyphenyl)Methylene)Malononitrile
  • 2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile
  • Intermediate of Ibrutinib, Note separate 2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile
  • 2-(Methoxy(4- phenoxyphenyl)Methylene)Malononitri
  • ROPANEDINITRILE, 2-[METHOXY(4-PHENOXYPHENYL)METHYLENE]-
  • Zanubrutinib Related Compound 3
  • Zanubrutinib Impurity 5
  • 7-(1-(3-(4-(3-carbamoyl-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl)-3-oxopropyl)piperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
  • Triamide impurity
  • Methoxy(4phenoxyphenyl)methyli dene]propanedinitrile
  • Zanubrutinib dimer impurity
  • 1,1-dicyano-2-Methoxy-2-(4-Phenoxyphenyl)Ethylene
  • 330792-69-3
  • 30792-69-3