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RS-102895 hydrochloride

Product Name
RS-102895 hydrochloride
CAS No.
1173022-16-6
Chemical Name
RS-102895 hydrochloride
Synonyms
3-trihydroxybenzene;RS-102895;RS 102895;RS102895;1'-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)
CBNumber
CB52729375
Molecular Formula
C21H22ClF3N2O2
Formula Weight
426.86
MOL File
1173022-16-6.mol
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RS-102895 hydrochloride Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMF: 25 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18207
Product name
RS 102895 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
18207
Product name
RS 102895 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
18207
Product name
RS 102895 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$133
Updated
2024/03/01
Cayman Chemical
Product number
18207
Product name
RS 102895 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$288
Updated
2024/03/01
TRC
Product number
R701005
Product name
RS 102895 hydrochloride
Packaging
10mg
Price
$145
Updated
2021/12/16
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RS-102895 hydrochloride Chemical Properties,Usage,Production

Description

The chemokine CCL2, also known as monocyte chemotactic protein-1 (MCP-1), stimulates leukocyte chemotaxis to sites of inflammation via signaling through the MCP-1 receptor, CCR2. RS 102895 is a spiropiperidine compound that acts as a CCR2 antagonist (IC50 = 0.36 μM). It inhibits the related CCR1 receptor with an IC50 value of 17.8 μM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC50 values of 0.13, 0.32, and 47 μM, respectively. RS 102895 prevents chemotaxis of THP-1 cells (IC50 = 1.7 μM) when MCP-1 is presented as a chemoattractant.

Uses

RS 102895 Hydrochloride is used as a leukocyte infiltrate marker for rosacea diagnosis.

storage

Desiccate at RT

RS-102895 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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RS-102895 hydrochloride Suppliers

China 46 India 1 United Kingdom 1 United States 8 Global 56
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from RS-102895 hydrochloride manufacturers

Career Henan Chemical Co
Product
RS-102895 hydrochloride 1173022-16-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-18

1173022-16-6, RS-102895 hydrochlorideRelated Search:

Pyridine hydrochloride Aniline hydrochloride Trimethylamine hydrochloride Methylamine hydrochloride

  • Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride
  • RS-102895;RS 102895;RS102895
  • Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)
  • 3-trihydroxybenzene
  • 1'-(4-(Trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride
  • 1173022-16-6