ChemicalBook > CAS DataBase List > 4-Bromo-2-nitrophenol

4-Bromo-2-nitrophenol

Product Name
4-Bromo-2-nitrophenol
CAS No.
7693-52-9
Chemical Name
4-Bromo-2-nitrophenol
Synonyms
nsc402972;4-Bromo-nitrophenol;4-Bromo-2-nitrophel;4-BROMO-2-NITROPHENOL;4-bromo-2-nitro-pheno;2-NITRO-4-BROMOPHENOL;PHENOL, 2-NITRO-5-BROMO-;Phenol, 4-bromo-2-nitro-;4-Bromo-2-nitrophenol,98%;4-Bromo-2-nitrophenol >
CBNumber
CB5273414
Molecular Formula
C6H4BrNO3
Formula Weight
218
MOL File
7693-52-9.mol
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4-Bromo-2-nitrophenol Property

Melting point:
90-94 °C (lit.)
Boiling point:
259.4±20.0 °C(Predicted)
Density 
1.8994 (rough estimate)
refractive index 
1.6090 (estimate)
storage temp. 
Sealed in dry,Room Temperature
pka
6.28±0.14(Predicted)
form 
Crystalline Powder or Crystals
color 
Yellow
Water Solubility 
Slightly soluble
InChI
InChI=1S/C6H4BrNO3/c7-4-1-2-6(9)5(3-4)8(10)11/h1-3,9H
InChIKey
CUTFAPGINUFNQM-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(Br)C=C1[N+]([O-])=O
CAS DataBase Reference
7693-52-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-20/22
Safety Statements 
26-36-36/37/39
WGK Germany 
3
RTECS 
SJ8370000
Hazard Note 
Harmful
HS Code 
29089990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
309877
Product name
4-Bromo-2-nitrophenol
Purity
98%
Packaging
5g
Price
$42.9
Updated
2024/03/01
Sigma-Aldrich
Product number
309877
Product name
4-Bromo-2-nitrophenol
Purity
98%
Packaging
25g
Price
$137
Updated
2023/06/20
TCI Chemical
Product number
B2363
Product name
4-Bromo-2-nitrophenol
Purity
>98.0%(GC)
Packaging
5g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
B2363
Product name
4-Bromo-2-nitrophenol
Purity
>98.0%(GC)
Packaging
25g
Price
$138
Updated
2024/03/01
Alfa Aesar
Product number
H26529
Product name
4-Bromo-2-nitrophenol, 98%
Packaging
5g
Price
$47.65
Updated
2024/03/01
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4-Bromo-2-nitrophenol Chemical Properties,Usage,Production

Description

4-bromo-2-nitrophenol is an essential intermediate for fine chemical engineering. It can be used to synthesize derivatives with biological activity, such as heterocyclic compounds as peptidase inhibitors for treating diabetes, introducing fluorine-containing groups as pesticides, and aminic compounds as Btk inhibitors for treating immune diseases.

Chemical Properties

yellow crystalline powder or crystals

Synthesis Reference(s)

The Journal of Organic Chemistry, 32, p. 300, 1967 DOI: 10.1021/jo01288a012
Synthesis, p. 287, 1989

General Description

The Suzuki coupling of 4-bromo-2-nitrophenol with boronic acid was studied.

Synthesis

The synthesis method of 4-bromo-2-nitrophenol comprises the following steps: preparing nitric acid with a concentration of 7-8 M; dissolving p-bromophenol in dichloroethane to obtain a substrate with a concentration of 1.8-2.2 M; injecting the nitric acid and the substrate into a continuous flow reactor through two pumps respectively, mixing, controlling the temperature at 55-75°C, the reaction pressure at 0.35-0.45 MPa, and reacting for 20-30 min.

4-Bromo-2-nitrophenol Preparation Products And Raw materials

Raw materials

Potassium peroxymonosulfate Sodium sulfate Sodium chloride Sodium nitrite 4-Bromophenol Nitric acid Dichloromethane

Preparation Products

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4-Bromo-2-nitrophenol Suppliers

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View Lastest Price from 4-Bromo-2-nitrophenol manufacturers

Suzhou Nordica Biopharma CO.,LTD
Product
4-Bromo-2-nitrophenol 7693-52-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
5 tons
Release date
2024-10-23
Henan Fengda Chemical Co., Ltd
Product
4-Bromo-2-nitrophenol 7693-52-9
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Nanjing Kaitian Chemical Co., LTD
Product
2-Nitro-4-bromophenol 7693-52-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2 tons
Release date
2022-12-06

7693-52-9, 4-Bromo-2-nitrophenolRelated Search:

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