NBQX DISODIUM SALT
- Product Name
- NBQX DISODIUM SALT
- CAS No.
- 118876-58-7
- Chemical Name
- NBQX DISODIUM SALT
- Synonyms
- NBQX;FG 9202;NBQX NEW;NBQX HYDRATE;NBQX DISODIUM;FG 9202 DISODIUM;Dihydroxyquinone;NBQX DISODIUM SALT;FG9202;FG-9202;FG 9202;NBQX disodium salt hydrate
- CBNumber
- CB5274224
- Molecular Formula
- C12H8N4O6S
- Formula Weight
- 336.28
- MOL File
- 118876-58-7.mol
NBQX DISODIUM SALT Property
- Melting point:
- 361°C
- Density
- 1.6027 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- methanol: 0.25 mg/mL
- form
- solid
- pka
- 7.55±0.20(Predicted)
- color
- yellow
- Stability:
- Freezer at -20°C
- InChIKey
- UQNAFPHGVPVTAL-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N171
- Product name
- NBQX hydrate
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- N171
- Product name
- NBQX hydrate
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $444
- Updated
- 2024/03/01
- Product number
- N183
- Product name
- NBQX disodium salt hydrate
- Purity
- ≥98% (HPLC), lyophilized solid
- Packaging
- 5mg
- Price
- $320
- Updated
- 2024/03/01
- Product number
- N183
- Product name
- NBQX disodium salt hydrate
- Purity
- ≥98% (HPLC), lyophilized solid
- Packaging
- 25mg
- Price
- $1290
- Updated
- 2024/03/01
- Product number
- 0373
- Product name
- NBQX
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $910
- Updated
- 2021/12/16
NBQX DISODIUM SALT Chemical Properties,Usage,Production
Chemical Properties
Yellow Crystalline Solid
Uses
A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.
Uses
NBQX disodium salt hydrate has been used:
- in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
- as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
- in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)
Definition
ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative.
General Description
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.
Biological Activity
Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ .
Biochem/physiol Actions
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.
storage
Room temperature
NBQX DISODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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