NBQX DISODIUM SALT

ChemicalBook > CAS DataBase List > NBQX DISODIUM SALT

Product Name: NBQX DISODIUM SALT
CAS No.: 118876-58-7
Chemical Name: NBQX DISODIUM SALT
Synonyms: NBQX;FG 9202;NBQX NEW;NBQX HYDRATE;NBQX DISODIUM;FG 9202 DISODIUM;Dihydroxyquinone;NBQX DISODIUM SALT;FG9202;FG-9202;FG 9202;NBQX disodium salt hydrate
CBNumber: CB5274224
Molecular Formula: C12H8N4O6S
Formula Weight: 336.28
MOL File: 118876-58-7.mol

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NBQX DISODIUM SALT Property

Melting point:: 361°C
Density: 1.6027 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: methanol: 0.25 mg/mL
form: solid
pka: 7.55±0.20(Predicted)
color: yellow
Stability:: Freezer at -20°C
InChIKey: UQNAFPHGVPVTAL-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N171
Product name: NBQX hydrate
Purity: powder, ≥98% (HPLC)
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Sigma-Aldrich

Product number: N171
Product name: NBQX hydrate
Purity: powder, ≥98% (HPLC)
Packaging: 25mg
Price: $444
Updated: 2024/03/01

Sigma-Aldrich

Product number: N183
Product name: NBQX disodium salt hydrate
Purity: ≥98% (HPLC), lyophilized solid
Packaging: 5mg
Price: $320
Updated: 2024/03/01

Sigma-Aldrich

Product number: N183
Product name: NBQX disodium salt hydrate
Purity: ≥98% (HPLC), lyophilized solid
Packaging: 25mg
Price: $1290
Updated: 2024/03/01

Tocris

Product number: 0373
Product name: NBQX
Purity: ≥98%(HPLC)
Packaging: 50
Price: $910
Updated: 2021/12/16

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NBQX DISODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

Yellow Crystalline Solid

Uses

A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.

Uses

NBQX disodium salt hydrate has been used:

in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSC_NMDAR)

Definition

ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative.

General Description

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.

Biological Activity

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ .

Biochem/physiol Actions

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.

storage

Room temperature

NBQX DISODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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118876-58-7, NBQX DISODIUM SALTRelated Search:

DNQX CNQX (RS)-AMPA 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE 1,8-Dihydroxyanthraquinone NBQX DISODIUM SALT 6-NITROQUINOXALINE-2,3-DIONE 4-Nitro-1-naphthylamine 6-NITRO-1,2,3,4-TETRAHYDRO QUINOXALINE 7-NITRO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE N'-METHYL-4-NITROPHENYLENEDIAMINE-(1,2) 1,2,3,4-Tetrahydro-quinoxalin-6-ylamine 2,3-Quinoxalinedione,6-amino-1,4-dihydro-(9CI) NBQX DISODIUM SALT N-ACETYL-4-NITRO-1-NAPHTHYLAMINE [10-3H]NBQX ACETAMIDE, N-(4-AMINO-1-NAPHTHYL)- 2,3-QUINOXALINEDIONE, 1,4-DIHYDRO-6-NITRO-, MONOHYDRATE

NBQX

2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline

FG 9202, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate

FG 9202 hydrate disodium salt, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate disodium salt

NBQX hydrate disodium salt

2,3-Doxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline

FG 9202 disodium salt hydrate

2,3-Dihydroxy-6-nitrobenzo[f]quinoxaline-7-sulfonamide

6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3(1H,4H)-dione

1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate

NBQX disodium salt hydrate

6-Nitro-2,3-dioxo-2,3-dihydrobenzo[f]quinoxaline-7-sulfonamide

NBQX DISODIUM

NBQX DISODIUM SALT

1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate

disodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate hydrate

FG9202;FG-9202;FG 9202

2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline

6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE-2,3-DIONE

6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE-2,3-DIONE, DISODIUM SALT

6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2,3-DIONE

6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2,3-DIONE 2NA

1,2,3,4-TETRAHYDRO-6-NITRO-2,3-DIOXO-BENZO[F]QUINOXALINE-7-SULFONAMIDE

1,2,3,4-TETRAHYDRO-6-NITRO-2,3-DIOXO-BENZO[F]QUINOXALINE-7-SULFONAMIDE DISODIUM

2,3-DIHYDROXY-6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE

2,3-DIHYDROXY-6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE 2NA

2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE

2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE DISODIUM SALT

FG 9202

FG 9202 DISODIUM

NBQX DISODIUM (FG 9202) NEUROPROTECTIVE GLUTA

NBQX HYDRATE

1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt

NBQX NEW

Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-

6-Nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide

Dihydroxyquinone

NBQX disodium salt (mM/ml), AMPA / kainate antagonist

NBQX, AMPA / kainate antagonist

118876-58-7

C12H6N4Na2O6S

C12H8N4O6S

C12H6N4O6SNa2

Ligand-Gated Ion Channels

Ionotropic Glutamate Receptor Modulators

Ion Channels

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Glutamate

Glutamate receptor

Heterocyclic Compounds

Neurochemicals