1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE

Product Name: 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE
CAS No.: 178616-26-7
Chemical Name: 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE
Synonyms: CFM-2;CFM2,CFM 2;CFM-2, 10 mM in DMSO;CFM 2, AMPA receptor antagonist;1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE;4H-2,3-Benzodiazepin-4-one,1-(4-aminophenyl)-3,5-dihydro-7,8-dimethoxy-
CBNumber: CB2280501
Molecular Formula: C17H17N3O3
Formula Weight: 311.34
MOL File: 178616-26-7.mol

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1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE Property

Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble in DMSO
pka: 12.53±0.40(Predicted)
form: Off-white solid.
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1082
Product name: CFM-2
Purity: ≥98%(HPLC)
Packaging: 10
Price: $160
Updated: 2021/12/16

Tocris

Product number: 1082
Product name: CFM-2
Purity: ≥98%(HPLC)
Packaging: 50
Price: $672
Updated: 2021/12/16

TRC

Product number: C291723
Product name: CFM-2
Packaging: 25mg
Price: $365
Updated: 2021/12/16

Usbiological

Product number: 254925
Product name: CFM-2
Packaging: 10mg
Price: $466
Updated: 2021/12/16

ChemScene

Product number: CS-3625
Product name: CFM-2
Purity: 98.93%
Packaging: 10mg
Price: $174
Updated: 2021/12/16

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1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE Chemical Properties,Usage,Production

Uses

CFM-2 is a non-competitive antagonist of the AMPA receptors.

Definition

ChEBI: 1-(4-aminophenyl)-7,8-dimethoxy-3,5-dihydro-2,3-benzodiazepin-4-one is a benzodiazepine.

Biological Activity

Novel, selective non-competitive AMPA antagonist. Highly potent, long-acting anticonvulsant.

in vivo

Pretreatment with CFM-2 delays the progression of seizure rank during repeated administration of pentylentetrazole. At the end of the period of repeated pentylentetrazole treatment (6 weeks) the mean seizure score was 0 in vehicle treated controls, 4.3 in animals treated with vehicle + pentylentetrazole, 2.2 in rats treated chronically with CFM-2 (20 μmol/kg; i.p.) + pentylentetrazole and 1.0 in rats treated repeatedly with CFM-2 (50 μmol/kg; i.p.) + pentylenetetrazole. CFM-2 is also able to antagonize the long-term increase in sensitivity of the convulsant effects of GABA function inhibitors in pentylentetrazole-kindled animals^[1].Intrathecal application of two selective non-competitive AMPAR antagonists, CFM-2 (25 and 50 μg) and GYKI 52466 (50μg), significantly attenuated mechanical and thermal hypersensitivities on the ipsilateral hind paw at 2 and 24 h post-CFA injection. Neither CFM-2 nor GYKI 52466 affects the contralateral basal responses to thermal and mechanical stimuli^[4].

storage

Room temperature

1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE Suppliers

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178616-26-7, 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONERelated Search:

(S)-AMPA CYCLOTHIAZIDE NBQX DISODIUM SALT KYNURENIC ACID DNQX CNQX (RS)-AMPA 1-[2-(3,4-dimethoxyphenyl)ethyl]hydrazine 1-[2-(2-methylphenyl)ethyl]hydrazine 3,4-DIMETHOXYPHENYLACETIC ACID HYDRAZIDE 2-(3-METHOXYPHENYL)ETHANOHYDRAZIDE 1-(3-methoxyphenethyl)hydrazine hydrochloride (4-HYDROXY-PHENYL)-ACETIC ACID HYDRAZIDE 2-(4-METHOXYPHENYL)ACETOHYDRAZIDE (p-Methoxyphenethyl)hydrazine 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE

CFM-2

4H-2,3-Benzodiazepin-4-one,1-(4-aminophenyl)-3,5-dihydro-7,8-dimethoxy-

1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE

CFM2,CFM 2

CFM 2, AMPA receptor antagonist

CFM-2, 10 mM in DMSO

178616-26-7

C17H17N3O3

Glutamate receptor