3-Bromo-6-chloro-1H-indazole

Product Name: 3-Bromo-6-chloro-1H-indazole
CAS No.: 885521-34-6
Chemical Name: 3-Bromo-6-chloro-1H-indazole
Synonyms: 6-Chloro-3-bromo-indazole;1H-INDAZOLE,3-BROMO-6-CHLORO-;3-BROMO-6-CHLORO (1H)INDAZOLE;3-bromo-6-chloro-1H-indazole - [B87745]
CBNumber: CB5282647
Molecular Formula: C7H4BrClN2
Formula Weight: 231.48
MOL File: 885521-34-6.mol

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3-Bromo-6-chloro-1H-indazole Property

Melting point:: 193 °C
Boiling point:: 368.5±22.0 °C(Predicted)
Density: 1.878
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 10?+-.0.40(Predicted)
Appearance: yellow solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B704498
Product name: 3-Bromo-6-chloro-1H-indazole
Packaging: 1mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152539
Product name: 6-Chloro-3-bromo-indazole
Packaging: 25mg
Price: $51
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152539
Product name: 6-Chloro-3-bromo-indazole
Packaging: 50mg
Price: $89
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152539
Product name: 6-Chloro-3-bromo-indazole
Packaging: 100mg
Price: $155
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC152539
Product name: 6-Chloro-3-bromo-indazole
Packaging: 250mg
Price: $310
Updated: 2021/12/16

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3-Bromo-6-chloro-1H-indazole Chemical Properties,Usage,Production

Synthesis

698-25-9

885521-34-6

Step 1a. 6-Chloro-1H-indazole (3.0 g, 19.66 mmol) was suspended in 2 M NaOH solution (70 mL) and a solution of bromine (2.32 g, 14.52 mmol) in 2 M NaOH (30 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the pH was adjusted to 8 with 3 M HCl, followed by liquid-liquid partitioning with ethyl acetate and brine. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether) to afford the target compound 3-bromo-6-chloro-1H-indazole as a yellow solid (3.4 g, 44% yield).ESI-MS m/z = 231.00, 233.00 [M + H]+.

References

[1] Synthesis, 2011, # 16, p. 2651 - 2663
[2] Patent: WO2016/183266, 2016, A1. Location in patent: Page/Page column 44-45
[3] Patent: US2016/289212, 2016, A1. Location in patent: Paragraph 0191
[4] Patent: WO2013/169907, 2013, A1. Location in patent: Paragraph 00115

3-Bromo-6-chloro-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-6-chloro-1H-indazole Suppliers

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3-bromo-6-chloro-1H-indazole - [B87745]

885521-34-6