ChemicalBook > CAS DataBase List > PURVALANOL A

PURVALANOL A

Product Name
PURVALANOL A
CAS No.
212844-53-6
Chemical Name
PURVALANOL A
Synonyms
NG-60;PurvaL;CH61386;CS-1631;PURVALANOL A;CDKinhibitor;(R)-Purvalanol A;NG 60;NG60;NG-60;PURVALANOLA, >98%;PurvalanolA/CH61386
CBNumber
CB5283664
Molecular Formula
C19H25ClN6O
Formula Weight
388.89
MOL File
212844-53-6.mol
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PURVALANOL A Property

Boiling point:
590.5±60.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
methylene chloride: 50 mg/mL, clear, colorless
form 
powder
pka
14.51±0.10(Predicted)
color 
off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Safety

WGK Germany 
3
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
540500
Product name
Purvalanol A
Packaging
1mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
P4484
Product name
Purvalanol A
Purity
≥98% (HPLC), powder
Packaging
1mg
Price
$144
Updated
2023/06/20
Cayman Chemical
Product number
14579
Product name
Purvalanol A
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14579
Product name
Purvalanol A
Purity
≥98%
Packaging
10mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
14579
Product name
Purvalanol A
Purity
≥98%
Packaging
50mg
Price
$275
Updated
2024/03/01
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PURVALANOL A Chemical Properties,Usage,Production

Description

Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1?Reversibly arrests synchronized cells in G1 and G2 phase.2?Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3?Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4?In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5?Cell permeable.

Uses

Purvalanol A acts as a potent, cell-permeable CDK inhibitor used in the treatment of cell proliferative disorders. Anti-cancer.

Definition

ChEBI: Purvalanol A is a purvalanol.

Biological Activity

Cyclin-dependent kinase inhibitor. IC 50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

storage

Store at +4°C

References

1) Gray?et al.?(1998),?Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors; Science,?281?533 2) Villerbu?et al.?(2002),?Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities; Int. J. Cancer,?97?761 3) Coker-Gurkan?et al.?(2015),?Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time dependent manner in HCT116 colon cancer cells; Oncol. Rep.,?33?2761 4) Hikita?et al.?(2010),?Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src; Genes Cells,?15?1051 5) Goga?et al.?(2007),?Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC; Nat. Med.,?13?820

PURVALANOL A Preparation Products And Raw materials

Raw materials

Preparation Products

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PURVALANOL A Suppliers

China 67 Germany 1 India 1 Switzerland 2 United Kingdom 7 United States 20 Global 98
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View Lastest Price from PURVALANOL A manufacturers

Career Henan Chemical Co
Product
PURVALANOL A 212844-53-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

212844-53-6, PURVALANOL ARelated Search:

2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE OLOMOUCINE II SU 9516 NU6102 OLOMOUCINE QNZ (EVP4593) Roscovitine Ro 3306 N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE NU6140 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A AMINOPURVALANOL A PURVALANOL B 2-Aminopurine 6-ANILINOPURINE PURVALANOL A

  • PURVALANOL A
  • NG-60
  • 6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE
  • (2R)-2-[[6-[(3-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
  • 2-(1R-ISOPROPOYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
  • 2-(1R-ISOPROPYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYL-PURINE
  • CH61386
  • 2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanolCDKinhibitor.
  • PurvalanolA,CDKinhibitor
  • CDKinhibitor
  • PurvalanolA/CH61386
  • Purvalanol A(NG 60)
  • (R)-Purvalanol A
  • (R)-2-(6-(3-chlorophenylamino)-9-isopropyl-9H-purin-2-ylamino)-3-methylbutan-1-ol
  • NG-60, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine
  • Purvalanol A - CAS 212844-53-6 - Calbiochem
  • NG 60;NG60;NG-60
  • CS-1631
  • PURVALANOLA, >98%
  • PurvaL
  • 1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-
  • PURVALANOL A USP/EP/BP
  • (2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
  • 212844-53-6
  • C19H25ClN6O
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cell Cycle Regulators
  • Cell Cycle
  • Apoptosis and Cell Cycle
  • Inhibitors
  • Signalling