BOC-3-AMINOBENZOIC ACID
- Product Name
- BOC-3-AMINOBENZOIC ACID
- CAS No.
- 111331-82-9
- Chemical Name
- BOC-3-AMINOBENZOIC ACID
- Synonyms
- BOC-M-ABZ-OH;BOC-3-ABZ-OH;Boc-3-Abz-OH >=97.0%;Boc-3-AminobenzoicAci;BOC-3-AMINOBENZOIC ACID;3-(BOC-AMINO)BENZOIC ACID;3-(n-Boc amino)benzoic acid;BOC-3-AMINOBENZOIC ACID USP/EP/BP;Boc-3-aminobenzoic acid≥ 99% (HPLC);Boc-3-Abz-OH(Boc-3-aMinobenzoic Acid)
- CBNumber
- CB5288962
- Molecular Formula
- C12H15NO4
- Formula Weight
- 237.25
- MOL File
- 111331-82-9.mol
BOC-3-AMINOBENZOIC ACID Property
- Melting point:
- 195 °C (dec.)
- Boiling point:
- 339.8±25.0 °C(Predicted)
- Density
- 1.242±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.15±0.10(Predicted)
- Appearance
- White to off-white Solid
- BRN
- 5813611
- CAS DataBase Reference
- 111331-82-9(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15298
- Product name
- Boc-3-Abz-OH
- Purity
- ≥97.0%
- Packaging
- 10g
- Price
- $251.3
- Updated
- 2025/07/31
- Product number
- B657175
- Product name
- Boc-3-Abz-OH
- Packaging
- 1g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 162924
- Product name
- Boc-3-Abz-OH
- Packaging
- 250mg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- 041689
- Product name
- Boc-3-Abz-OH
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 05105
- Product name
- Boc-3-aminobenzoic acid
- Purity
- ≥ 99% (HPLC)
- Packaging
- 1G
- Price
- $10
- Updated
- 2021/12/16
BOC-3-AMINOBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
Brown powder
Uses
Boc-3-Abz-OH, is an intermediate in the synthesis of various pharmaceutical compounds, including inhibitors, and therapeutic agents. It can also be used in the preparation of conformationally-constrained cyclic peptides with biarylamine linkers.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
99-05-8
111331-82-9
GENERAL METHOD: To a stirred solution of m-aminobenzoic acid (5.00 g, 36.5 mmol) and sodium hydroxide (1.56 g, 39.3 mmol) in a solvent mixture of 1:1 water/dioxane (60 mL) at 0 °C was slowly added di-tert-butyl dicarbonate (14.3 g, 65.4 mmol). The reaction mixture was continued to be stirred at 0 °C for 3 h, followed by slow warming to room temperature and stirring overnight. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (60 mL) and the extraction was repeated once (60 mL). The organic phases were combined and neutralized with 1 M aqueous KHSO4 to pH ≈ 7. The organic layer was separated, washed with water (60 mL) and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give 3-(N-Boc-amino)benzoic acid (7.53 g, 87% yield) as an off-white solid, which could be used in the next reaction without further purification.
References
[1] Journal of Medicinal Chemistry, 2001, vol. 44, # 3, p. 441 - 452
[2] Tetrahedron, 2012, vol. 68, # 6, p. 1790 - 1801
[3] Patent: US2014/194383, 2014, A1. Location in patent: Paragraph 0500; 0507-0508
[4] Chemical Communications, 2013, vol. 49, # 66, p. 7340 - 7342
[5] Bioorganic and Medicinal Chemistry, 2018,
BOC-3-AMINOBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-3-AMINOBENZOIC ACID manufacturers
- Product
- BOC-3-AMINOBENZOIC ACID 111331-82-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08