ChemicalBook > CAS DataBase List > Benidipine hydrochloride

Benidipine hydrochloride

Product Name: Benidipine hydrochloride
CAS No.: 91599-74-5
Chemical Name: Benidipine hydrochloride
Synonyms: (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1);Conipros;Benidipin;rac-Benidipine HCl;Benidipine hydrochlo;Benidipine Impurity 4;Benidipine hydrochloride;rac Benidipine Hydrochloride;Benidipine hydrochloride USP/EP/BP;Benidipine hydrochloride - Bio-X ?
CBNumber: CB5294563
Molecular Formula: C28H31N3O6.HCl
Formula Weight: 542.02
MOL File: 91599-74-5.mol

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Benidipine hydrochloride Property

Melting point:: 199-201°C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: ≥20mg/mL
pka: 7.34(at 25℃)
form: powder
color: yellow
InChIKey: DGVVISBYHUXFIU-UHFFFAOYSA-N
SMILES: C(C1=C(NC(=C([C@H]1C1C=CC=C(C=1)N(=O)=O)C(=O)OC)C)C)(=O)O[C@@H]1CCCN(C1)CC1C=CC=CC=1.Cl
CAS DataBase Reference: 91599-74-5(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
RTECS: US7975657
HS Code: 2933.99.5300
HazardClass: 6.1
Toxicity: LD50 orally in male mice: 218 mg/kg (Muto, 1988)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B6813
Product name: Benidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $80.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: B6813
Product name: Benidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $309
Updated: 2025/07/31

TCI Chemical

Product number: B5629
Product name: Benidipine Hydrochloride
Packaging: 100MG
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: B5629
Product name: Benidipine Hydrochloride
Packaging: 1G
Price: $213
Updated: 2025/07/31

Cayman Chemical

Product number: 21607
Product name: Benidipine (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

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Benidipine hydrochloride Chemical Properties,Usage,Production

Description

Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.

Description

Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC₅₀ of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.

Chemical Properties

Yellow Crystalline Powder

Originator

Kyowa Hakko (Japan)

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

brand name

Coniel

Biological Activity

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Safety Profile

A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.

Synthesis

14813-01-5

74936-72-4

91599-74-5

Under sonication conditions, 10 g of monomethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate was placed in a 200 mL reaction flask, to which 14 mL of N,N-dimethylformamide (DMF) and 56 mL of dichloromethane were added. Under ice bath conditions, 2.4 mL of thionyl chloride was slowly added to the resulting homogeneous suspension, followed by stirring the reaction mixture for 1 hour until a clarified solution was formed. Next, 6.3 g of 1-benzyl-3-piperidinol was added and stirring was continued for 2.5 hours under ice bath conditions. Upon completion of the reaction, the reaction solution was washed with 40 mL of water (repeated 4 times) and 40 mL of saturated brine solution (1 time). The organic phase was dried by adding 4 g of anhydrous sodium sulfate for 2 hours. After drying, the sodium sulfate solid was removed by filtration and the dichloromethane was recovered by distillation under reduced pressure to give the crude yellow to red (R)-rel-3-((R)-1-benzylpiperidin-3-yl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride. The crude product was dissolved in 100 mL of acetone and sonicated at 150 W and 40 kHz for 7 min, followed by filtration under reduced pressure and drying to give 5.9 g of yellow powdery product in 36.2% yield.

storage

room temperature (desiccate)

References

[1] Patent: WO2012/142815, 2012, A1. Location in patent: Page/Page column 5; 6

Benidipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Benidipine hydrochloride manufacturers

Guangzhou Tosun Pharmaceutical Ltd

Product: Benidipine hydrochloride 91599-74-5
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 95%+
Supply Ability: 1000mg
Release date: 2024-12-30

Baoji Guokang Healthchem Co., Ltd.

Product: Benidipine hydrochloride 91599-74-5
Price: US $1050.00/g/Bag
Min. Order: 100g
Purity: 99%
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Release date: 2021-06-03

Shaanxi Dideu New Materials Co. Ltd

Product: Benidipine hydrochloride 91599-74-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000KGS
Release date: 2025-02-18

91599-74-5, Benidipine hydrochlorideRelated Search:

DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Chromium picolinate Topotecan hydrochloride Benidipine Dimethyl sulfoxide N,N-Dimethylformamide Dihydromyrcenol ETHANE Dimethyl ether Quinolinic acid Lercanidipine hydrochloride Dimethyl phthalate Benzyldimethylcarbinyl butyrate Dimethylbenzylcarbinyl acetate Manidipine hydrochloride Pyridine Dimethyl sulfide Dimethyl fumarate

(R,R)-(+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDRO-3,5-PYRIDINE,DICARBOXYLIC ACID METHYL-1-BENZYL-3-PIPERIDYL-ESTER,MONOHYDROCHLORIDE SALT

Coniel, Capadipine, KW-3049, Nacadipine

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)-

(R,R)-(+/-)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-Dihydro-3,5-pyridine-dicarboxylic acid methyl-1-benzyl-3-piperidyl-ester hydrochloride

Benidipine hydrochloride

monohydrochloride,(r*,r*)-(+-)-hyl1-(phenylmethyl)-3-piperidinyleste

1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOLATE

2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-DimethoxyCarboxylate

(R,R)-(+/)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidmethyl-1-(phenylmethyl)-3-piperidiny

rac-Benidipine HCl

Benidipine hydrochlo

(4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, hydrochloride (1:1)

(4R)-rel-3,5-Pyridinedicarboxylic acid

3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester

Conipros

rac-(4R*)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R*)-1-benzylpiperidine-3-yl]·hydrochloride

(4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid3-methyl5-[(3R)-1-(phenylmethyl)-3-piperidinyl]esterhydrochloride

rac Benidipine Hydrochloride

Benidipine Impurity 4

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, hydrochloride (1:1), (4R)-rel-

(3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)

3-[(3RS)-1-Benzylpiperidin-3-yl] 5-Methyl (4RS)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride

Benidipine hydrochloride USP/EP/BP

(R)-rel-3-((R)-1-Benzylpiperidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate,hydrochloride

3-[(R*)-1-Benzylpiperidin-3-yl] (R*)-5-Methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride

Benidipin

(R,R)(S,S)-Benidipine Hydrochloride

(±)-(R*)-3-[(R*)-1-Benzyl-3-piperidyl]methyl 1,4-dihydro-2,6-dimethyl- 4-(m-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride

(3R*)-1-Benzylpiperidin-3-yl methyl (4R*)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Cocaine Hydrochloride Impurity 3(Cocaine Hydrochloride EP Impurity C )(β-Truxilline)

Benidipine hydrochloride, 10 mM in DMSO

Benidipine hydrochloride - Bio-X ?

91599-74-5

91599-47-5

C28H32ClN3O6

C28H31N3O6

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Antihypertensive

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