Benidipine hydrochloride

Product Name: Benidipine hydrochloride
CAS No.: 91599-74-5
Chemical Name: Benidipine hydrochloride
Synonyms: (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1);Conipros;Benidipin;rac-Benidipine HCl;Benidipine hydrochlo;Benidipine Impurity 4;Benidipine hydrochloride;rac Benidipine Hydrochloride;Benidipine hydrochloride USP/EP/BP;(R,R)(S,S)-Benidipine Hydrochloride
CBNumber: CB5294563
Molecular Formula: C28H31N3O6.HCl
Formula Weight: 542.02
MOL File: 91599-74-5.mol

More

Less

Benidipine hydrochloride Property

Melting point:: 199-201°C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: ≥20mg/mL
pka: 7.34(at 25℃)
form: powder
color: yellow
InChIKey: DGVVISBYHUXFIU-UHFFFAOYSA-N
CAS DataBase Reference: 91599-74-5(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
RTECS: US7975657
HS Code: 2933.99.5300
Toxicity: LD50 orally in male mice: 218 mg/kg (Muto, 1988)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B6813
Product name: Benidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $91.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: B6813
Product name: Benidipine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $354
Updated: 2024/03/01

TCI Chemical

Product number: B5629
Product name: Benidipine Hydrochloride
Packaging: 100MG
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: B5629
Product name: Benidipine Hydrochloride
Packaging: 1G
Price: $237
Updated: 2024/03/01

Cayman Chemical

Product number: 21607
Product name: Benidipine (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

More

Less

Benidipine hydrochloride Chemical Properties,Usage,Production

Description

Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.

Description

Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC₅₀ of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.

Chemical Properties

Yellow Crystalline Powder

Originator

Kyowa Hakko (Japan)

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

brand name

Coniel

Biological Activity

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Safety Profile

A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.

storage

room temperature (desiccate)

Benidipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Benidipine hydrochloride Suppliers

Americas 1 Canada 4 CHINA 187 Europe 3 France 1 Germany 4 India 24 Italy 1 Japan 4 South Korea 2 Switzerland 1 The Netherlands 1 United Kingdom 11 United States 36 Global 280

Unipex

Tel: --
Fax: --
Email: hemical@unipex.com
Country: France
ProdList: 267
Advantage: 58

More

Less

View Lastest Price from Benidipine hydrochloride manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: Benidipine hydrochloride 91599-74-5
Price: US $1050.00/g/Bag
Min. Order: 100g
Purity: 99%
Supply Ability: 10kg
Release date: 2021-06-03

Zhuozhou Wenxi import and Export Co., Ltd

Product: Benidipine hydrochloride 91599-74-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: Benidipine hydrochloride 91599-74-5
Price: US $1050.00/g
Min. Order: 100g
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-03

91599-74-5, Benidipine hydrochlorideRelated Search:

DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Chromium picolinate Topotecan hydrochloride Benidipine Dimethyl sulfoxide N,N-Dimethylformamide Dihydromyrcenol ETHANE Dimethyl ether Quinolinic acid Lercanidipine hydrochloride Dimethyl phthalate Benzyldimethylcarbinyl butyrate Dimethylbenzylcarbinyl acetate Manidipine hydrochloride Pyridine Dimethyl sulfide Dimethyl fumarate

(R,R)-(+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDRO-3,5-PYRIDINE,DICARBOXYLIC ACID METHYL-1-BENZYL-3-PIPERIDYL-ESTER,MONOHYDROCHLORIDE SALT

Coniel, Capadipine, KW-3049, Nacadipine

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)-

(R,R)-(+/-)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-Dihydro-3,5-pyridine-dicarboxylic acid methyl-1-benzyl-3-piperidyl-ester hydrochloride

Benidipine hydrochloride

monohydrochloride,(r*,r*)-(+-)-hyl1-(phenylmethyl)-3-piperidinyleste

1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOLATE

2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-DimethoxyCarboxylate

(R,R)-(+/)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidmethyl-1-(phenylmethyl)-3-piperidiny

rac-Benidipine HCl

Benidipine hydrochlo

(4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, hydrochloride (1:1)

(4R)-rel-3,5-Pyridinedicarboxylic acid

3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester

Conipros

rac-(4R*)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R*)-1-benzylpiperidine-3-yl]·hydrochloride

(4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid3-methyl5-[(3R)-1-(phenylmethyl)-3-piperidinyl]esterhydrochloride

rac Benidipine Hydrochloride

Benidipine Impurity 4

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, hydrochloride (1:1), (4R)-rel-

(3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)

3-[(3RS)-1-Benzylpiperidin-3-yl] 5-Methyl (4RS)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride

Benidipine hydrochloride USP/EP/BP

(R)-rel-3-((R)-1-Benzylpiperidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate,hydrochloride

3-[(R*)-1-Benzylpiperidin-3-yl] (R*)-5-Methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride

Benidipin

(R,R)(S,S)-Benidipine Hydrochloride

(±)-(R*)-3-[(R*)-1-Benzyl-3-piperidyl]methyl 1,4-dihydro-2,6-dimethyl- 4-(m-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride

(3R*)-1-Benzylpiperidin-3-yl methyl (4R*)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Cocaine Hydrochloride Impurity 3(Cocaine Hydrochloride EP Impurity C )(β-Truxilline)

91599-74-5

91599-47-5

C28H32ClN3O6

C28H31N3O6

Inhibitors

Antihypertensive

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics

Chiral Reagents

Heterocycles