N,N-Dimethylformamide di-tert-butyl acetal

Product Name: N,N-Dimethylformamide di-tert-butyl acetal
CAS No.: 36805-97-7
Chemical Name: N,N-Dimethylformamide di-tert-butyl acetal
Synonyms: 1,1-di-tert-butoxy-N,N-dimethylmethanamine;N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL;N,N-Di-tert-butoxytrimethylamine;1,1-DI-TERT-BUTOXYTRIMETHYLAMINE;Di-tert-butoxyMethyl-diMethyl-aMine;Di-tert-butoxy(dimethylamino)methane;[bis(tert-butoxy)methyl]dimethylamine;N,N-Dimethyldi-tert-butoxymethanamine;N,N-DIMETHYLFORMAMIDE DI-T-BUTYL ACETAL;N,N-Dimethyldi(tert-butyloxy)methanamine
CBNumber: CB5296219
Molecular Formula: C11H25NO2
Formula Weight: 203.32
MOL File: 36805-97-7.mol

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N,N-Dimethylformamide di-tert-butyl acetal Property

Boiling point:: 56-57 °C8 mm Hg(lit.)
Density: 0.848 g/mL at 25 °C(lit.)
refractive index: n20/D 1.413(lit.)
Flash point:: 93 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Miscible with toluene and benzene.
form: clear liquid
pka: 5.34±0.50(Predicted)
color: Colorless to Almost colorless
Specific Gravity: 0.848
Sensitive: Moisture Sensitive
BRN: 969629
InChI: InChI=1S/C11H25NO2/c1-10(2,3)13-9(12(7)8)14-11(4,5)6/h9H,1-8H3
InChIKey: DBNQIOANXZVWIP-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(OC(C)(C)C)N(C)C
CAS DataBase Reference: 36805-97-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 10-36/37/38
Safety Statements: 26-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
F: 10-21
HazardClass: 3
PackingGroup: III
HS Code: 29221990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 40263
Product name: N,N-Dimethylformamide di-tert-butyl acetal
Purity: technical, ≥90% (GC)
Packaging: 10ml
Price: $406
Updated: 2024/03/01

Sigma-Aldrich

Product number: 40263
Product name: N,N-Dimethylformamide di-tert-butyl acetal
Purity: technical, ≥90% (GC)
Packaging: 50mL
Price: $876
Updated: 2024/03/01

Sigma-Aldrich

Product number: 395005
Product name: N,N-Dimethylformamide di-tert-butyl acetal
Purity: for GC derivatization
Packaging: 5ml
Price: $91.7
Updated: 2022/05/15

Sigma-Aldrich

Product number: 395005
Product name: N,N-Dimethylformamide di-tert-butyl acetal
Purity: for GC derivatization
Packaging: 10x1ml
Price: $207
Updated: 2022/05/15

TCI Chemical

Product number: D1303
Product name: N,N-Dimethylformamide Di-tert-butyl Acetal [for Esterification]
Purity: >98.0%(N)
Packaging: 5mL
Price: $115
Updated: 2024/03/01

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N,N-Dimethylformamide di-tert-butyl acetal Chemical Properties,Usage,Production

Uses

Reagent used for the preparation of indolizines via intermolecular cyclization of picolinium salts.

Uses

N,N-Dimethylformamide di-tert-butyl acetal may be used in the synthesis of following:

(S)-2-(1-tert-butoxycarbonyl-2-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}ethylamino)benzoic acid methyl ester
3-O-tert-butylmorphine
tert-butylesters of pyrrole- and indolecarboxylic acids

Synthesis Reference(s)

Synthetic Communications, 15, p. 723, 1985 DOI: 10.1080/00397918508063864

General Description

N,N-Dimethylformamide di-tert-butyl acetal is an derivatizing reagent.

Synthesis

A mixture of 59.5 g (0.5 mol) of N, N-dimethylformamide dimethyl acetal and 147 mL (1.5 mol) of dry tert-butanol in a three-necked flask (250 mL) fitted with a thermometer magnetic stirrer, nitrogen inlet and a 33 x 1.9 cm silvered vacuum jacketed Goodloe column which was equipped with a reflux controlled take-off distilling head was heated at reflux for 1 hr, then 300 mg of 2,4,6-tri-tert-butylphenol was added. The reaction mixture was heated at 100-115°C for 48 hrs, during which time, at the rate of two drops/min, 56 mL of distillate was collected. Another 50 mL (0.52 mol) of tert-butanol was added to the reaction mixture, and the removal of methanol was continued for an additional 42 hrs to afford 64 mL of distillate. Distillation of the crude product with a similar but smaller column (20 x 1.4 cm) gave 53.2 g (52%) of N, N-Dimethylformamide di-tert-butyl acetal[1].

References

[1] Mohacsi, E. “A New Synthetic Method for the Preparation of N,N-Dimethylformamide DI-Tert-Butyl Acetal.” Synthetic Communications 15 1 (1985): 723–725.

N,N-Dimethylformamide di-tert-butyl acetal Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N-Dimethylformamide di-tert-butyl acetal Suppliers

Americas 1 Belgium 1 Canada 2 China 106 Europe 1 Germany 6 India 6 Japan 3 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 25 Global 163

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View Lastest Price from N,N-Dimethylformamide di-tert-butyl acetal manufacturers

Shijiazhuang Leon Chemicals Co.,Ltd

Product: N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL 36805-97-7
Price: US $1.00-1.00/kg
Min. Order: 1kg
Purity: 90%
Supply Ability: 10 tons
Release date: 2024-08-13

Career Henan Chemical Co

Product: 1,1-Di-tert-butoxytrimethylamine 36805-97-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-05

36805-97-7, N,N-Dimethylformamide di-tert-butyl acetalRelated Search:

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N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACET AL, DERIVATIZATION GRADE

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N,N-Dimethylformamide Di-tert-butyl Acetal [for Esterification]

1,1-di-tert-butoxy-N,N-dimethylmethanamine

[bis(tert-butoxy)methyl]dimethylamine

Di-tert-butyl dimethylformamide acetal (DMF di-tert-butyl acetal)

N,N-Dimethylformamide di-tert-butyl acetal,1,1-Di-tert-butoxy-N,N-dimethylmethylamine, 1,1-Di-tert-butoxytrimethylamine

Di-tert-butoxyMethyl-diMethyl-aMine

N,N-Di-tert-butoxytrimethylamine

N,N-Dimethylformamide Di-tert-butyl Acetal&nbsp

N,N-Dimethylformamide di-tert-butyl acetal, technical, 90%

N,N-DiMethylforMaMide Di-tert-butyl Acetal [for Esterification], 98.0%(N)

N,N-DIMETHYLFORMAMIDE DI-T-BUTYL ACETAL

N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACETAL

N,N-DIMETHYLFORMAMIDE DI-TERT-BUTYL ACET AL, TECH., 90+%

1,1-bis(1,1-dimethylethoxy)-n,n,n-trimethylamine

1,1-Di-tert-butoxy-N,N-dimethylmethylamine

1,1-DI-TERT-BUTOXYTRIMETHYLAMINE

N,N-Dimethylformamide Di-tert-butyl Acetal [for Esterification]&gt

Methanamine, 1,1-bis(1,1-dimethylethoxy)-N,N-dimethyl-

36805-97-7

CH32NCHOCH332

CH32NCHOCCH332

C11H25NO2

GC Derivatizing Reagents

Esterification & Alkylation (GC Derivatizing Reagents)

N,N-Dimethylformamide Dialkylacetals (GC Derivatizing Reagents)

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Esterification & Alkylation (GC Derivatizing Reagents)

GC Derivatizing Reagents

N,N-Dimethylformamide Dialkylacetals (GC Derivatizing Reagents)