sn-Glycero-3-phosphocholine

Product Name: sn-Glycero-3-phosphocholine
CAS No.: 28319-77-9
Chemical Name: sn-Glycero-3-phosphocholine
Synonyms: Alpha GPC;GPC;CHOLINE ALFOSCERATE;glycerophosphocholine;SN-GLYCERO-3-PHOSPHOCHOLINE;GLYCEROPHOSPHORYLCHOLINE;L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE;Alpha GPC powder;L-α-glycerylphosphorylcholine;L-A-glycerophosphorylcholine
CBNumber: CB5309777
Molecular Formula: C8H20NO6P
Formula Weight: 257.22
MOL File: 28319-77-9.mol

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sn-Glycero-3-phosphocholine Property

Melting point:: 142.5-143°
alpha: D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8)
Boiling point:: 480℃[at 101 325 Pa]
vapor pressure: 0Pa at 25℃
Flash point:: 11 °C
storage temp.: -20°C
solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Sparingly), Water (Sparingly)
form: solid
color: White to Off-White
biological source: soybean
Water Solubility: 1000g/L at 25℃
Stability:: Very Hygroscopic
InChI: InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3
InChIKey: SUHOQUVVVLNYQR-SBYBRXNCNA-N
SMILES: P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO |&1:12,r|
LogP: -5.15 at 25℃
CAS DataBase Reference: 28319-77-9(CAS DataBase Reference)

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 16-36/37-45-24/25
RIDADR: UN 1230 3/PG 2
WGK Germany: 2
RTECS: KH2775000
HS Code: 29239000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G5291
Product name: L-α-Glycerophosphorylcholine
Purity: from soybean, ≥98%, powder
Packaging: 50mg
Price: $184
Updated: 2024/03/01

Sigma-Aldrich

Product number: G5291
Product name: L-α-Glycerophosphorylcholine
Purity: from soybean, ≥98%, powder
Packaging: 100mg
Price: $318
Updated: 2024/03/01

Cayman Chemical

Product number: 20736
Product name: sn-glycero-3-Phosphocholine
Purity: ≥95%
Packaging: 1g
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 20736
Product name: sn-glycero-3-Phosphocholine
Purity: ≥95%
Packaging: 5g
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: G5291
Product name: L-α-Glycerophosphorylcholine
Purity: from soybean, ≥98%, powder
Packaging: 10mg
Price: $63.8
Updated: 2024/03/01

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sn-Glycero-3-phosphocholine Chemical Properties,Usage,Production

Description

Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.

Chemical Properties

Choline glycerophosphate (GPC) is a white waxy solid that is miscible with water, soluble in methanol and ethanol, and insoluble in chloroform, ether, oil, etc. It has no characteristic absorption under UV visible light. The methods for determining GPC content include high-performance liquid chromatography (equipped with an evaporative light scattering detector or refractive index differential detector) and the digestion phosphorus determination method.

Originator

Sandoz; Italfarmaco (Italy)

Uses

sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.

Uses

L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids.

Definition

ChEBI: Choline alfoscerate is a member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines.

brand name

Delecit

General Description

L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Increases inositol phosphate formation.

Synthesis

10 g of phosphorylcholine chloride (1 equivalent, 228 mmol) was dissolved in 200 ml of methanol in a 500 ml three-necked round bottom flask equipped with a thermometer, a reflux condenser and a stirrer. Then, 5.1 g of potassium hydroxide (2 equivalents, 455 mmol) Lt; / RTI & gt; stirred for 1 hour. After warming the reaction to 65 ° C, 10 g of (R) -3-chloro-1,2-propanediol (2 eq, 452 mmol) was added slowly and refluxed for 16 hours to carry out the substitution reaction. After completion of the reaction, 10 ml of water was added to the concentrate obtained by concentration under reduced pressure, and the reaction product was diluted with acetone twice. The aqueous layer was concentrated under reduced pressure to obtain 11.60 g of L-α-glycerophosphorylcholine (sn-Glycero-3-phosphocholine; yield: 99%).

sn-Glycero-3-phosphocholine Preparation Products And Raw materials

Raw materials

Preparation Products

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sn-Glycero-3-phosphocholine Suppliers

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View Lastest Price from sn-Glycero-3-phosphocholine manufacturers

Dorne Chemical Technology co. LTD

Product: Choline glycerophosphate 28319-77-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-03-26

Hebei Miaoyin Technology Co.,Ltd

Product: Alpha-GPC Chonile Alfoscerate 28319-77-9
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000
Release date: 2023-04-07

Jinan Million Pharmaceutical Co., Ltd

Product: Choline glycerophosphate 28319-77-9
Price: US $1.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99%
Supply Ability: 200KG
Release date: 2024-07-26

28319-77-9, sn-Glycero-3-phosphocholineRelated Search:

Choline hydroxide Sodium Phosphate Monobasic Monohydrate Citiolone Trisodium phosphate Choline chloride Zinc phosphate CYCLAZOSIN HYDROCHLORIDE Creatine phosphate phosphorylcholine OLEYLOXYETHYL PHOSPHORYLCHOLINE Acetylcholine Choline bitartrate Ammonium dihydrogen phosphate Lecithin Ferric phosphate Calcium phosphate phosphate Glycinamide hydrochloride

2-[[(2R)-2,3-dihydroxypropoxy]-hydroxy-phosphoryl]oxyethyl-trimethyl-azanium

L-A-GLYCEROPHOSPHORYLCHOLINE FROM*EGG YOLK FREE FORM

L-A-GLYCEROPHOSPHORYLCHOLINE FROM SOYBEAN, FREE FORM

L-α-GLYCERYLPHOSPHORYLCHOLINE(GPC)

,hydroxide,innersalt,(r)-

L-a-Glycerophosphorylcholine (anhydrous) (GPC)

GLYCERYLPHOSPHOCHOLINE

L-A-GLYCEROPHOSPHOCHOLINE

2-(((2,3-Dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium inner salt

2,3-Dihydroxypropyl 2-trimethylazaniumylethyl phosphate

L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE(ALPHA-GPC)

L-α-Glycerophoshorylchoilne

L-α-glycerylphosphorylcholine

L-á-Glycerophosphorylcholine (from egg yolk)

L-alpha-glycerol phosphorylcholine

L-α-Glycerophosphorylcholine inner salt

Choline, hydroxide, 2,3-dihydroxypropyl hydrogen phosphate, inner salt, D-

Ethanaminium, 2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, hydroxide, inner salt, (R)-

2-[[(R)-2,3-Dihydroxypropyl]oxy(oxylato)phosphinyloxy]-N,N,N-trimethylethanaminium

L-Glycerophosphocholine

L-α-Glycerophosphocholine

L-α-Glycerophosphorylcholine ,99%

L-A-glycerophosphorylcholine

Alpha GPC

L-Alpha-Glycerlphorcholine

Choline glycerophosphate

GLYCEROPHOSPHOCHOLINE(GPC)(P)

Alpha GPC(Choline Alfoscerato)

Sn-Glycero-3-phosphocholine(GPC)

sn-Glycero-3-phosphocholine (Choline Alfoscerate)

2-(((2,3-dihydroxypropoxy)hydroxyphosphinyl)oxy)-n,n,n-trimethyl-ethanaminiu

glycerophosphocholine

hydroxide,2,3-dihydroxypropylhydrogenphosphate,innersalt,d-cholin

l-alpha-glycerophosphocholine

SN-GLYCERO-3-PHOSPHOCHOLINE

SN-GLYCERO-3-PHOSPHOCHOLINE INNER SALT

SN-GLYCEROPHOSPHORYLCHOLINE (EGG)

SN-3-GLYCEROPHOSPHOCHOLINE

L-ALPHA-GLYCEROPHOSPHORYLCHOLINE

L-ALPHA-GLYCEROPHOSPHORYLCHOLINE INNER SALT

L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE

CHOLINE ALFOSCERATE

GLYCEROPHOSPHORYLCHOLINE

GPC

(R)-2,3-Dihydroxypropyl (2-(triMethylaMMonio)ethyl) phosphate

Alpha-GPC (or Choline Alfoscerate)

L-α-Glycerylphosphorylcholine (GPC),anhydrous

Cholini alfosceras

Colina glicerofosfato

Alpha-GlyceroPhosphatidylCholine

EthanaMiniuM,2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-triMethyl-, innersalt

(R)-2,3-dihydroxypropyl (2-(triMethylaMMonio)ethyl) phosphate (GPC)

Choline glycerophosphate SynonyMs Alfa-GPC

Choline glycerophosphate 2,3-Dihydroxypropyl 2-trimethylazaniumylethyl phosphate

Alfa-GPC

L-a-Glycerophosphorylcholine (choline alfoscerate) (GPC)

Choline glycerophosphate (GPC)

2-[[[(2R)-2,3-Dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-triMethylethanaMiniuM Inner Salt