ChemicalBook > CAS DataBase List > 6-ForMylindolo[3,2-b]carbazole

6-ForMylindolo[3,2-b]carbazole

Product Name
6-ForMylindolo[3,2-b]carbazole
CAS No.
172922-91-7
Chemical Name
6-ForMylindolo[3,2-b]carbazole
Synonyms
FICZ;6-FORMYLINDOLO A CARBAZOLE;6-FORMYLINDOLO [3,2-B] CARBAZOLE;6-Formylindolo[3,2-b]carbazole (FICZ);Indolo[3,2-b]carbazole-6-carbaldehyde;5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ;Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-
CBNumber
CB5312397
Molecular Formula
C19H12N2O
Formula Weight
284.31
MOL File
172922-91-7.mol
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6-ForMylindolo[3,2-b]carbazole Property

Boiling point:
630.3±35.0 °C(Predicted)
Density 
1.463±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 10 mg/ml).
form 
powder
pka
15.66±0.30(Predicted)
color 
yellow to orange
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Safety

WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1489
Product name
FICZ
Purity
≥95% (HPLC)
Packaging
1MG
Price
$131
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1489
Product name
FICZ
Purity
≥95% (HPLC)
Packaging
5MG
Price
$530
Updated
2023/06/20
Cayman Chemical
Product number
19529
Product name
6-Formylindolo[3,2-b]carbazole
Purity
≥95%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
19529
Product name
6-Formylindolo[3,2-b]carbazole
Purity
≥95%
Packaging
1mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
19529
Product name
6-Formylindolo[3,2-b]carbazole
Purity
≥95%
Packaging
5mg
Price
$448
Updated
2024/03/01
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6-ForMylindolo[3,2-b]carbazole Chemical Properties,Usage,Production

Description

6-Formylindolo(3,2-b)carbazole (FICZ) (172922-91-7) is a very potent (Kd?= 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2

Uses

6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma.

Biochem/physiol Actions

FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.

storage

Store at -20°C

References

1) Rannung?et al. (1987)?Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances; J. Biol. Chem.,?262?15422 .2) Wincent?et al. (2009)?The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b}carbazole is Present in Humans; J. Biol. Chem.,?284?2690

6-ForMylindolo[3,2-b]carbazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-ForMylindolo[3,2-b]carbazole Suppliers

Wuxi Donghe Pharmaceutical Technology Co., Ltd.
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63313187 15358055255
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QQ:63313187
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63313187@qq.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Nanjing Norris-Pharm Technology Co., Ltd
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13901585132
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+86-25-52131256
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Haoyuan Chemexpress Co., Ltd.
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(86) 21-58955996
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CEG Chemical Science&Technology Co., Ltd.
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Shanghai Macklin Biochemical Co.,Ltd.
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021-50706099
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shenlinxing@macklin.cn
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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BOC Sciences
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United States
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Yancheng KangdiSen Pharmaceutical Co., Ltd.
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13812573443
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885
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China
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172922-91-7, 6-ForMylindolo[3,2-b]carbazoleRelated Search:


  • 6-FORMYLINDOLO [3,2-B] CARBAZOLE
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  • 5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde
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  • 5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
  • 6-FORMYLINDOLO A CARBAZOLE
  • Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-
  • 6-Formylindolo[3,2-b]carbazole (FICZ)
  • inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ
  • 172922-91-7
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