6-ForMylindolo[3,2-b]carbazole
- Product Name
- 6-ForMylindolo[3,2-b]carbazole
- CAS No.
- 172922-91-7
- Chemical Name
- 6-ForMylindolo[3,2-b]carbazole
- Synonyms
- FICZ;6-FORMYLINDOLO A CARBAZOLE;6-FORMYLINDOLO [3,2-B] CARBAZOLE;6-Formylindolo[3,2-b]carbazole (FICZ);Indolo[3,2-b]carbazole-6-carbaldehyde;5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ;Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-
- CBNumber
- CB5312397
- Molecular Formula
- C19H12N2O
- Formula Weight
- 284.31
- MOL File
- 172922-91-7.mol
6-ForMylindolo[3,2-b]carbazole Property
- Boiling point:
- 630.3±35.0 °C(Predicted)
- Density
- 1.463±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml).
- form
- powder
- pka
- 15.66±0.30(Predicted)
- color
- yellow to orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety
- WGK Germany
- 1
N-Bromosuccinimide Price
- Product number
- SML1489
- Product name
- FICZ
- Purity
- ≥95% (HPLC)
- Packaging
- 1MG
- Price
- $131
- Updated
- 2023/06/20
- Product number
- SML1489
- Product name
- FICZ
- Purity
- ≥95% (HPLC)
- Packaging
- 5MG
- Price
- $530
- Updated
- 2023/06/20
- Product number
- 19529
- Product name
- 6-Formylindolo[3,2-b]carbazole
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 19529
- Product name
- 6-Formylindolo[3,2-b]carbazole
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 19529
- Product name
- 6-Formylindolo[3,2-b]carbazole
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $448
- Updated
- 2024/03/01
6-ForMylindolo[3,2-b]carbazole Chemical Properties,Usage,Production
Description
6-Formylindolo(3,2-b)carbazole (FICZ) (172922-91-7) is a very potent (Kd?= 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2
Uses
6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma.
Biochem/physiol Actions
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
storage
Store at -20°C
References
1) Rannung?et al. (1987)?Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances; J. Biol. Chem.,?262?15422 .2) Wincent?et al. (2009)?The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b}carbazole is Present in Humans; J. Biol. Chem.,?284?2690