ChemicalBook > CAS DataBase List > (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

Product Name
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
CAS No.
1196504-54-7
Chemical Name
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
Synonyms
EOS-62352;GDC0575 hydrochloride;GDC0575 monohydrochloride;GDC0575 monohydrochloride,GDC-0575 monohydrochloride;(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
CBNumber
CB53142373
Molecular Formula
C16H21BrClN5O
Formula Weight
414.73
MOL File
1196504-54-7.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FG172882
Product name
GDC 0575 hydrochloride
Packaging
50mg
Price
$1100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FG172882
Product name
GDC 0575 hydrochloride
Packaging
100mg
Price
$1350
Updated
2021/12/16
Biosynth Carbosynth
Product number
FG172882
Product name
GDC 0575 hydrochloride
Packaging
250mg
Price
$2400
Updated
2021/12/16
Biosynth Carbosynth
Product number
FG172882
Product name
GDC 0575 hydrochloride
Packaging
500mg
Price
$2850
Updated
2021/12/16
AK Scientific
Product number
2505DT
Product name
GDC0575hydrochloride
Packaging
500mg
Price
$3897
Updated
2021/12/16
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(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Chemical Properties,Usage,Production

Description

GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.

in vitro

CHK1 inhibitor (CHK1i) GDC-0575 enhances AraC-mediated killing of AML cells both in vitro and in vivo, thus abrogating any potential chemoresistance mechanisms involving DNA repair._x000D_ _x000D_ Reference: Nat Commun. 2017 Nov 22;8(1):1679. https://pubmed.ncbi.nlm.nih.gov/29162833/

target

GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2?nM.

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Suppliers

China 13 United States 2 Global 15
ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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2853530910@QQ.com
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Shanghai Chaolan Chemical Technology Center
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21-5161 9052
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Sales@ATKchemical.com
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Shanghai Dongyang Biotechnology Co., Ltd.
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0512-0512-13601744364 13601744364
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DC Chemicals
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Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
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sales2@sunwaypharm.com
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TargetMol Chemicals Inc.
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Nanjing Tengyi Biotechnology Co., Ltd
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025-58851786 17714337195
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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China
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https://hanhongsci.com/
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021-54306202 18917919676
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info@hanhongsci.com
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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ATK CHEMICAL COMPANY LIMITED
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+undefined-21-51877795
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+86 21 5161 9052/ 5187 7796
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ivan@atkchemical.com
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32957
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1196504-54-7, (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamideRelated Search:

giredestrant (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide GDC0575 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide GDC-0077 (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one XL518 DONEPEZIL HYDROCHLORIDE

  • (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
  • EOS-62352
  • GDC0575 hydrochloride
  • GDC0575 monohydrochloride
  • GDC0575 monohydrochloride,GDC-0575 monohydrochloride
  • 1196504-54-7