2-Deoxy-D-ribose

ChemicalBook > CAS DataBase List > 2-Deoxy-D-ribose

Product Name: 2-Deoxy-D-ribose
CAS No.: 533-67-5
Chemical Name: 2-Deoxy-D-ribose
Synonyms: Deoxyribose;D-2-DEOXYRIBOSE;THYMINOSE;2-DEOXYRIBOSE;D-erythro-Pentose, 2-deoxy-;(3S,4R)-3,4,5-trihydroxypentanal;desoxyribose;D-deoxyribose;(2R,4S,5R)-5-(hydroxyMethyl)tetrahy-drofuran-2,4-diol;ribodesose
CBNumber: CB5315585
Molecular Formula: C5H10O4
Formula Weight: 134.13
MOL File: 533-67-5.mol

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2-Deoxy-D-ribose Property

Melting point:: 89-90 °C(lit.)
alpha: -57 º (c=1, H2O, 24hr)
Boiling point:: 167.23°C (rough estimate)
Density: 1.0590 (rough estimate)
refractive index: -56 ° (C=1, H2O)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form: Crystalline Powder
pka: 12.61(at 25℃)
color: White to slightly yellow
optical activity: [α]22/D 59°, c = 1 in H2O
Water Solubility: soluble
Sensitive: Hygroscopic
Merck: 14,2908
BRN: 1721978
Stability:: Hygroscopic
InChIKey: ASJSAQIRZKANQN-CRCLSJGQSA-N
CAS DataBase Reference: 533-67-5(CAS DataBase Reference)
NIST Chemistry Reference: D-Erythro-pentose, 2-deoxy-(533-67-5)
EPA Substance Registry System: D-erythro-Pentose, 2-deoxy- (533-67-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-37/39-36-26
WGK Germany: 3
RTECS: SB7230000
F: 3-10
TSCA: Yes
HS Code: 29400000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 31170
Product name: 2-Deoxy-D-ribose
Purity: ≥99.0% (TLC)
Packaging: 1g
Price: $33.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 31170
Product name: 2-Deoxy-D-ribose
Purity: ≥99.0% (TLC)
Packaging: 5G
Price: $107
Updated: 2024/03/01

Sigma-Aldrich

Product number: 31170
Product name: 2-Deoxy-D-ribose
Purity: ≥99.0% (TLC)
Packaging: 25g
Price: $325
Updated: 2024/03/01

Sigma-Aldrich

Product number: 121649
Product name: 2-Deoxy-D-ribose
Purity: 97%
Packaging: 1g
Price: $17.22
Updated: 2024/03/01

TCI Chemical

Product number: D0059
Product name: 2-Deoxy-D-ribose
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $33
Updated: 2024/03/01

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2-Deoxy-D-ribose Chemical Properties,Usage,Production

Description

2-deoxy-D-Ribose is a reducing sugar formed as a degradation product during metabolism of thymidine by thymidine phosphorylase. It increases levels of reactive oxygen species (ROS) in HL-60 human leukemia cells when used at a concentration of 15 mM. 2-deoxy-D-Ribose (10 μM) induces tubulogenesis and migration of bovine aortic endothelial (BAE) cells. Topical administration of 2-deoxy-D-ribose increases blood vessel formation and accelerates wound healing in a rat full-thickness cutaneous wound model.

Uses

2-Deoxy-D-ribose (2dDR) can be used to prepare multifunctional wound dressings capable of inducing rapid angiogenesis with antimicrobial activity, such as 2dDR-SA hydrogel. The gel can be used to stimulate wound healing and treat superficial skin wounds, including chronic wound care. In addition, 2dDR gel has the potential to treat androgenetic alopecia and other causes of alopecia areata.

Uses

2-Deoxy-D-ribose is used as a precursor to deoxyribonucleic acid. It induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. Further, it is used in the synthesis of optically active dipyrrolyl alkanols from pyrroles on the surface of montmorillonite KSF clay.

Definition

ChEBI: 2-deoxy-D-ribose is a deoxypentose that is D-ribose in which the hydroxy group at position C-2 is replaced by hydrogen. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is functionally related to a D-ribose.

benefits

Hair Regrowth in Mice: Applying a small dose of 2-deoxy-D-ribose to mice models led to significant hair regrowth.
Blood Vessel Formation: The hair regrowth was linked to forming new blood vessels, enhancing blood supply to hair follicles.
Comparable to Minoxidil: The effectiveness of 2-deoxy-D-ribose in regrowing hair was similar to that of Minoxidil, a widely used hair loss treatment.

Biological Activity

2-Deoxy-D-ribose (2dDR) is a D-isomer of a deoxypentose monosaccharide in which a hydrogen atom is present with a hydroxyl group at the C-2 position in place of the hydroxyl group. 2dDR is known to enhance tubulogenesis, prevent hypoxia-induced apoptosis, and boost VEGF and IL-8 production of ECs in vitro, consistent with the stimulatory effects of 2dDR on cell proliferation and migration. 2dDR also stimulated angiogenesis, proliferation of endothelial cells, and accelerated wound healing in rat models. Additionally, 2dDR can be loaded into several biomaterials for prolonged release over several days to promote the growth of neonatal blood vessels[1].

References

[1] Anjum, Muhammad Awais et al. “Stimulation of hair regrowth in an animal model of androgenic alopecia using 2-deoxy-D-ribose.” Frontiers in Pharmacology 44 16 (2024).

2-Deoxy-D-ribose Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Deoxy-D-ribose manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 2-Deoxy-D-ribose 533-67-5
Price: US $999.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-21

Wuhan Fortuna Chemical Co.,Ltd

Product: 2-Deoxy-D-Ribose 533-67-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2024-08-26

Watson Biotechnology Co.,Ltd

Product: 2-Deoxy-D-ribose 533-67-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000KG
Release date: 2024-08-15

533-67-5, 2-Deoxy-D-riboseRelated Search:

Ribose L-Arabinopyranose D-Ribose Digitoxin CYMARIN D-(+)-DIGITOXOSE SEDOHEPTULOSE ANHYDRIDE D-(+)-TURANOSE CHROMOMYCIN A3 D-GALACTURONIC ACID LANATOSIDE A DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* 2-DEOXY-L-RIBOSE,2-DEOXY-L-RIBOSE 99% MUCIC ACID GITOXIN LANATOSIDE B 4-METHYLUMBELLIFERYL-ALPHA-L-FUCOPYRANOSIDE DIGOXIN

D-.alpha.-Ribodesose

Deoxyribose

D-Ribose, 2-deoxy-

2-deoxy-d-erythro-pentos

2-Deoxypentose

2-Desoxy ribosoe

D-(-)-2-DEOXYRIBOSE

D-2-DEOXYRIBOSE

D-2-DESOXYRIBOSE

2-Deoxy-beta-D-erythro-pentose

Deoxy-D-Ribose

2-DEOXY-D-RIBOSE CELL CULTURE TESTED

2-Deoxy-D-Ribose98.0%Min

2-Deoxy-D-ribose,99%

2-DEOXY-D-RIBOSE (D-REYTHRO-2-DEOXYPENTOSE)

D-erythro-Pentose, 2-deoxy-

2-DEOXY-D-RIBOSE,CRYSTALLINE

3,4,5-trihydroxypentanal

desoxyribose

ribodesose

2-DEOXY-D-RIBOSE BR

D-erythro-Pentose, 2-deoxy- 533-67-5

2-Deoxy-D-riboside

2-Doxy-D-Ribose

2-DEOXY-D-RIBOSE extrapure

2-Deoxy-D-arabinose, 2-Deoxy-D-erythropentose, Thyminose

Ribose, 2-deoxy-, D-

2-DEOXYRIBOSE

2-DESOXY-D-RIBOSE

2'-DEOXY-D-RIBOSE

2-DEOXY-D-RIBOSE

2-DEOXY-D-ARABINOSE

2-DEOXY-D-ERYTHRO-PENTOSE

D-ERYTHRO-2-DEOXYPENTOSE

DEOXY-D-RIBOSE,2-

TETRAHYDRO-2H-PYRAN-2,4,5-TRIOL

THYMINOSE

.alpha.-Deoxy-D-ribose

(2S,4S,5R)-Oxane-2,4,5-triol

D-deoxyribose

2-Deoxy-D-riboside >99%

(3S,4R)-3,4,5-trihydroxypentanal

(2R,4S,5R)-5-(hydroxyMethyl)tetrahy-drofuran-2,4-diol

2-Deoxy-D-ribose 97%

Cladribine Impurity E

NAPTHALENE NEAT

2-Deoxy-D-ribose (Zidovudine)

2-Deoxy-D-arabinose, low endotoxin ≤10 EU/mg

2-Deoxy-D-erythro-pentose, low endotoxin ≤10 EU/mg

2-Deoxy-D-ribose, low endotoxin ≤10 EU/mgCell culture grade, ≥ 99% (HPLC)

Cladribine Impurity 5(Cladribine EP Impurity E)

(2S,4S,5R)-5-(hydroxymethyl)oxolane-2,4-diol

Cladribine EP Impurity E

2DR(2-Deoxy-D-ribose)

2-Deoxy-D-ribose &gt

2'-Deoxy-D-RMbose,≥98%

(4S,5R)-Oxane-2,4,5-triol

2-Deoxy-D-ribose USP/EP/BP