(4-Hydroxy-2-methyl)phenylboronic acid
- Product Name
- (4-Hydroxy-2-methyl)phenylboronic acid
- CAS No.
- 493035-82-8
- Chemical Name
- (4-Hydroxy-2-methyl)phenylboronic acid
- Synonyms
- Tavaborole Impurity 3;4-Borono-3-methylphenol;Adipic Acid Impurity 11;5-hydroxytoluene-2-boronic acid;4-Hydroxy-2-methylphenylboronicaci;4-Hydroxy-2-methylphenylboronic aicd;(4-HYDROXY-2-METHYL)PHENYLBORONIC ACID;(4-HYDROXY-2-METHYL)BENZENEBORONIC ACID;B-(4-Hydroxy-2-methylphenyl)boronic acid;BORONIC ACID,B-(4-HYDROXY-2-METHYLPHENYL)-
- CBNumber
- CB5317615
- Molecular Formula
- C7H9BO3
- Formula Weight
- 151.96
- MOL File
- 493035-82-8.mol
(4-Hydroxy-2-methyl)phenylboronic acid Property
- Melting point:
- 100-104°C
- Boiling point:
- 361.4±52.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 9.17±0.58(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 493035-82-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41
- Safety Statements
- 26-36/37/39-39
- HazardClass
- IRRITANT
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H1495
- Product name
- 4-Hydroxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- H1495
- Product name
- 4-Hydroxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $507
- Updated
- 2025/07/31
- Product number
- H945880
- Product name
- (4-Hydroxy-2-methylphenyl)boronicAcid
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 280067
- Product name
- 5-Hydroxytoluene-2-boronic acid
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- H945880
- Product name
- (4-Hydroxy-2-methylphenyl)boronicAcid
- Packaging
- 10g
- Price
- $375
- Updated
- 2021/12/16
(4-Hydroxy-2-methyl)phenylboronic acid Chemical Properties,Usage,Production
Uses
suzuki reaction
Uses
(4-Hydroxy-2-methylphenyl)boronic Acid is a reactant in the preparation of biarylmethoxy nicotinamides as specific inhibitors of mycobacterium tuberculosis
Synthesis
946427-03-8
493035-82-8
The general procedure for the synthesis of 4-hydroxy-2-methylphenylboronic acid from 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is as follows: 1. sodium periodate (2.39 g, 11.15 mmol) was added to acetone and water (2:1, 36 mL) containing 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (870.4 mg, 3.72 mmol) and ammonium acetate (859.8 mg, 11.15 mmol) in a room temperature in a mixed solution. 2. The reaction mixture was stirred for 68 hours, then filtered and concentrated. 3. 3. Sodium chloride was added to the concentrated filtrate and extracted with ethyl acetate. 4. 4. The organic layer was dried with anhydrous magnesium sulfate, followed by filtration and concentration. 5. 5. The residue was purified by silica gel chromatography using 1:4 ethyl acetate:hexane as eluent to afford 275.7 mg (49% yield) of 4-hydroxy-2-methylphenylboronic acid as a solid. Product characterization data: 1H NMR (400 MHz, d6-DMSO): δ 9.28 (s, 1H), 7.70 (d, J = 9 Hz, 1H), 6.56-6.52 (m, 2H), 2.55 (s, 3H). ESI-LCMS m/z 151 (M-H)-.
References
[1] Patent: US2008/96921, 2008, A1. Location in patent: Page/Page column 82
(4-Hydroxy-2-methyl)phenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(4-Hydroxy-2-methyl)phenylboronic acid Suppliers
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- Country
- The Netherlands
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View Lastest Price from (4-Hydroxy-2-methyl)phenylboronic acid manufacturers
- Product
- (4-Hydroxy-2-methyl)phenylboronic acid 493035-82-8
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- (4-Hydroxy-2-methyl)phenylboronic acid 493035-82-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- (4-Hydroxy-2-methyl)phenylboronic acid 493035-82-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09