(4-Hydroxy-2-methyl)phenylboronic acid

Product Name: (4-Hydroxy-2-methyl)phenylboronic acid
CAS No.: 493035-82-8
Chemical Name: (4-Hydroxy-2-methyl)phenylboronic acid
Synonyms: Tavaborole Impurity 3;4-Borono-3-methylphenol;Adipic Acid Impurity 11;5-hydroxytoluene-2-boronic acid;4-Hydroxy-2-methylphenylboronicaci;4-Hydroxy-2-methylphenylboronic aicd;(4-HYDROXY-2-METHYL)PHENYLBORONIC ACID;(4-HYDROXY-2-METHYL)BENZENEBORONIC ACID;B-(4-Hydroxy-2-methylphenyl)boronic acid;BORONIC ACID,B-(4-HYDROXY-2-METHYLPHENYL)-
CBNumber: CB5317615
Molecular Formula: C7H9BO3
Formula Weight: 151.96
MOL File: 493035-82-8.mol

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(4-Hydroxy-2-methyl)phenylboronic acid Property

Melting point:: 100-104°C
Boiling point:: 361.4±52.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 9.17±0.58(Predicted)
color: White to Almost white
CAS DataBase Reference: 493035-82-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41
Safety Statements: 26-36/37/39-39
HazardClass: IRRITANT
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1495
Product name: 4-Hydroxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $150
Updated: 2025/07/31

TCI Chemical

Product number: H1495
Product name: 4-Hydroxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $507
Updated: 2025/07/31

TRC

Product number: H945880
Product name: (4-Hydroxy-2-methylphenyl)boronicAcid
Packaging: 1g
Price: $85
Updated: 2021/12/16

Usbiological

Product number: 280067
Product name: 5-Hydroxytoluene-2-boronic acid
Packaging: 500mg
Price: $333
Updated: 2021/12/16

TRC

Product number: H945880
Product name: (4-Hydroxy-2-methylphenyl)boronicAcid
Packaging: 10g
Price: $375
Updated: 2021/12/16

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(4-Hydroxy-2-methyl)phenylboronic acid Chemical Properties,Usage,Production

Uses

suzuki reaction

Uses

(4-Hydroxy-2-methylphenyl)boronic Acid is a reactant in the preparation of biarylmethoxy nicotinamides as specific inhibitors of mycobacterium tuberculosis

Synthesis

946427-03-8

493035-82-8

The general procedure for the synthesis of 4-hydroxy-2-methylphenylboronic acid from 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is as follows: 1. sodium periodate (2.39 g, 11.15 mmol) was added to acetone and water (2:1, 36 mL) containing 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (870.4 mg, 3.72 mmol) and ammonium acetate (859.8 mg, 11.15 mmol) in a room temperature in a mixed solution. 2. The reaction mixture was stirred for 68 hours, then filtered and concentrated. 3. 3. Sodium chloride was added to the concentrated filtrate and extracted with ethyl acetate. 4. 4. The organic layer was dried with anhydrous magnesium sulfate, followed by filtration and concentration. 5. 5. The residue was purified by silica gel chromatography using 1:4 ethyl acetate:hexane as eluent to afford 275.7 mg (49% yield) of 4-hydroxy-2-methylphenylboronic acid as a solid. Product characterization data: 1H NMR (400 MHz, d6-DMSO): δ 9.28 (s, 1H), 7.70 (d, J = 9 Hz, 1H), 6.56-6.52 (m, 2H), 2.55 (s, 3H). ESI-LCMS m/z 151 (M-H)-.

References

[1] Patent: US2008/96921, 2008, A1. Location in patent: Page/Page column 82

(4-Hydroxy-2-methyl)phenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (4-Hydroxy-2-methyl)phenylboronic acid manufacturers

Henan Fengda Chemical Co., Ltd

Product: (4-Hydroxy-2-methyl)phenylboronic acid 493035-82-8
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: (4-Hydroxy-2-methyl)phenylboronic acid 493035-82-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: (4-Hydroxy-2-methyl)phenylboronic acid 493035-82-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

493035-82-8, (4-Hydroxy-2-methyl)phenylboronic acidRelated Search:

Methyl acrylate Kresoxim-methyl 4-Hydroxybenzaldehyde 4-Hydroxybenzoic acid 3-Hydroxybenzoic acid 4-Hydroxyphenylboronic acid 3,5-Dimethylphenylboronic acid Bensulfuron methyl Methylparaben CHLOROPHOSPHONAZO III 4-Cyanophenol Triclosan 4-Methoxyphenol 2-Hydroxyphenylacetic acid Phenylboronic acid 4-Tolylboronic acid Methyl Parathion-methyl

(4-HYDROXY-2-METHYL)BENZENEBORONIC ACID

(4-HYDROXY-2-METHYL)PHENYLBORONIC ACID

4-Borono-3-methylphenol

5-hydroxytoluene-2-boronic acid

Boronic acid, (4-hydroxy-2-methylphenyl)- (9CI)

4-Borono-3-methylphenol, 2-Borono-5-hydroxytoluene

BORONIC ACID,B-(4-HYDROXY-2-METHYLPHENYL)-

4-Hydroxy-2-methylphenylboronic aicd

4-Hydroxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride)

Tavaborole Impurity 3

4-Hydroxy-2-methylphenylboronicaci

B-(4-Hydroxy-2-methylphenyl)boronic acid

4-Hydroxy-2-methylbenzeneboronic Acid (contains varying amounts of Anhydride)

Adipic Acid Impurity 11

493035-82-8

ALCOHOL

blocks

BoronicAcids

Boronate Ester

Boronic Acid

Potassium Trifluoroborate