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DIETHYLCARBAMAZINE CITRATE

Product Name
DIETHYLCARBAMAZINE CITRATE
CAS No.
1642-54-2
Chemical Name
DIETHYLCARBAMAZINE CITRATE
Synonyms
loxuran;filazine;franozan;hetrazan;caritrol;Dirocide;Longicid;franocide;Ditrazine;NSC 80513
CBNumber
CB5326262
Molecular Formula
C16H29N3O8
Formula Weight
391.42
MOL File
1642-54-2.mol
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DIETHYLCARBAMAZINE CITRATE Property

Melting point:
140 °C
Boiling point:
516.39°C (rough estimate)
Density 
1.1718 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
2-8°C
solubility 
Very soluble in water, soluble in ethanol (96 per cent), practically insoluble in acetone.
form 
powder
Water Solubility 
almost transparency
BRN 
3836352
CAS DataBase Reference
1642-54-2(CAS DataBase Reference)
EPA Substance Registry System
Diethylcarbamazine citrate (1642-54-2)
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Safety

Hazard Codes 
T+,T
Risk Statements 
22-26-23
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
TL1225000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933595960
Hazardous Substances Data
1642-54-2(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 1.38 g/kg (Harned)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

P310Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D8765
Product name
Diethylcarbamazine citrate salt
Purity
≥98%
Packaging
25g
Price
$117
Updated
2020/08/18
Sigma-Aldrich
Product number
D1300000
Product name
Diethylcarbamazine citrate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1193006
Product name
Diethylcarbamazine citrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$366
Updated
2021/03/22
TCI Chemical
Product number
D1898
Product name
Diethylcarbamazine Citrate
Purity
>98.0%(T)
Packaging
10g
Price
$194
Updated
2021/03/22
Sigma-Aldrich
Product number
D1300000
Product name
Diethylcarbamazine citrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
d1300000
Price
$190
Updated
2020/08/18
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DIETHYLCARBAMAZINE CITRATE Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder, slightly hygroscopic.

Originator

Hetrazan,Lederle,US,1949

Uses

Diethylcarbamazine Citrate can be used as an anthelmintic. The LD50 in rats is 1.38 g/kg.

Manufacturing Process

To 50 cc of water was added 18 grams of 1-methylpiperazine dihydrochloride and 8.34 grams of sodium hydroxide. When solution had been effected the beaker was cooled to 10°C and with stirring, 4.17 grams of sodium hydroxide dissolved in 15 cc of water and 14 grams of diethyl carbamyl chloride were added simultaneously. When all had been added, the solution was extracted 3 times with ether which was then dried and filtered. The ether solution was saturated with dry hydrogen chloride. A yellow gum appeared which on trituration gave a white, hygroscopic solid which was filtered and dried in a drying pistol. The N,N-diethyl-4-methyl-1-piperazine-carboxamide hydrochloride had a melting point of 150°-155°C.
If the compound itself is desired, the salt is dissolved in water and the solution saturated with a mild alkali such as potassium carbonate. The product is then extracted with chloroform, dried, and after removal of the chloroform, distilled.

Therapeutic Function

Anthelmintic

General Description

Crystalline solid, scored white tablets. Used against filariasis in man and animals.

Health Hazard

(Non-Specific -- Drugs, n.o.s.) May be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. The average adult man tolerates a single dose of 1.5 gm without ill effects.

Fire Hazard

When heated to decomposition, DIETHYLCARBAMAZINE CITRATE emits toxic fumes of nitrogen oxides. Avoid decomposing heat.

Safety Profile

Poison by inhalation and intravenous routes. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Once the hallmark agent for heartworm disease prophylaxis in dogs, DEC is no longer commercially available in the USA (in oral veterinary dosage forms). DEC is approved for use for the prophylaxis of heartworm disease (D. immitis), and/or the treatment of ascariasis in dogs. The drug is also used in ferrets and zoo animals susceptible to heartworm. DEC is used in dogs at higher dosages as alternative therapy for several other parasites (see Dosage section below). Some products were labeled for use in cats to treat ascarid infections.
In cats, DEC may help alleviate the course (preventing lymphoma development) of FeLV infection.
In the U.K., DEC is used as an injectable product to control parasitic bronchitis (Dictyocaulus viviparous) in sheep and cattle.
In humans, DEC is indicated as a filaricidal for the treatment of Wucheria bancrofti, Brugia malayi, Loa loa, and Onchocerca volvulus.

DIETHYLCARBAMAZINE CITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIETHYLCARBAMAZINE CITRATE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43495
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 QQ:452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11737
Advantage
57
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View Lastest Price from DIETHYLCARBAMAZINE CITRATE manufacturers

Dideu Industries Group Limited
Product
DIETHYLCARBAMAZINE CITRATE USP/EP/BP 1642-54-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-18
Shaanxi Dideu Medichem Co. Ltd
Product
DiethylcarbaMazine Citrate 1642-54-2
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 tons
Release date
2020-04-27
career henan chemical co
Product
DIETHYLCARBAMAZINE CITRATE 1642-54-2
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
98%
Supply Ability
1kg,2kg,100kg
Release date
2019-07-09

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