6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride
- Product Name
- 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride
- CAS No.
- 20232-39-7
- Chemical Name
- 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride
- Synonyms
- Tetrabenazine Impurity 2;Tetrabenazine Impurity 5;6,7-Dimethoxy-3,4-dihydroisoquinoline, HCl;3,4-Dihydro-6,7-dimethoxy-isoquinoline HCl;6,7-Dimethoxy-3,4-dihydroisoquinolineHClhydrate;6,7-dimethoxy-3,4-dihydroisoquinolinium chloride;3,4-dihydro-6,7-dimethoxy-isoquinolinhydrochloride;3,4-dihydro-6,7-dimethoxyisoquinolinehydrochloride;6,7-DiMethoxy-3,4-dihydroisoquinoline hydrochlorid;6,7-DIMETHOXY-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE
- CBNumber
- CB5338375
- Molecular Formula
- C11H14ClNO2
- Formula Weight
- 227.69
- MOL File
- 20232-39-7.mol
6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride Property
- Melting point:
- 198-202 °C
- RTECS
- NW7625000
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Pale yellow
- Water Solubility
- soluble
- InChI
- InChI=1S/C11H13NO2.ClH/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2;/h5-7H,3-4H2,1-2H3;1H
- InChIKey
- PQXVEYYRJHMTEV-UHFFFAOYSA-N
- SMILES
- C12CCN=CC=1C=C(OC)C(OC)=C2.Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P321Specific treatment (see … on this label).
N-Bromosuccinimide Price
- Product number
- D4629
- Product name
- 6,7-Dimethoxy-3,4-dihydroisoquinoline Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- D4629
- Product name
- 6,7-Dimethoxy-3,4-dihydroisoquinoline Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $79
- Updated
- 2025/07/31
- Product number
- D483398
- Product name
- 6,7-Dimethoxy-3,4-dihydroisoquinolineHydrochlorideHydrate
- Packaging
- 10g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- D470630
- Product name
- 6,7-Dimethoxy-3,4-dihydroisoquinolineHydrochlorideHydrate
- Packaging
- 10g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 43062
- Product name
- 6,7-Dimethoxy-3,4-dihydroisoquinolinehydrochloride,≥98%(HPLC)
- Purity
- ≥98%(HPLC)
- Packaging
- 1G
- Price
- $27.74
- Updated
- 2021/12/16
6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride Chemical Properties,Usage,Production
Chemical Properties
light yellow to yellow crystalline powder
Uses
6,7-Dimethoxy-3,4-dihydroisoquinoline is used in the synthesis of Tetrabenazine (T284000).
Uses
6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride is used in the synthesis of Tetrabenazine (T284000).
Synthesis
First, 3,4-dimethoxyphenethylamine (18.1 g, 0.1 mol) and ethyl formate (22.1 g) were added to a 100 mL three-necked flask protected by nitrogen, and the reaction was held at 60 ??C with stirring for 24 hours. Decompression and concentration to obtain N-(3,4-dimethoxyphenethyl)formamide crude product. The above crude product was dissolved in 180 mL of dichloromethane, phthaloyl dichloride (20.3 g, 0.1 mol) was added, and the reaction was stirred at 20??C for 4 h. The solid was gradually precipitated. Cooled to 10 ??, filtered to obtain 6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride crude product (mother liquor was washed twice with 50mL water, concentrated to recover dichloromethane, the residue was added to 100mL water, filtered to recover phthalic anhydride). Add the above crude product to isopropanol (180mL), heating to 70 ??, stirring 0.5-1h until all the solids are dissolved; add activated charcoal 1.8g, 80 ?? continue to stir for 2-3h, 50 ?? keep warm and filtration, filtrate re-warming to 70 ??, stirring for 0.5h; naturally cooled to 20 ??, it takes about 2h, filtration to get 6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride The finished product was 19.0 g. Yield 83%, HPLC purity 99.61%.
6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride manufacturers
- Product
- 6,7-Dimethoxy-3,4-dihydroisoquinoline Hydrochloride 20232-39-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-27
- Product
- 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride 20232-39-7
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-21
- Product
- 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride 20232-39-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 995
- Supply Ability
- 20mt
- Release date
- 2019-03-28