Z-CIS-HYP-OH

Product Name: Z-CIS-HYP-OH
CAS No.: 13504-86-4
Chemical Name: Z-CIS-HYP-OH
Synonyms: Z-CIS-HYP-OH;Z-L-CIS-HYP-OH;Z-cis-L-Hyp-OH;CBZ-cis-Hyp-OH;Z-CIS-HYDROXYPROLINE;Z-L-CIS-4-HYDROXYPROLINE;Z-CIS-4-HYDROXY-L-PROLINE;Z-L-cis-4-hydroxyproline99%;cis-N-Cbz-4-hydroxy-L-proline;N-Cbz-4-cis-Hydroxy-L-proline
CBNumber: CB5349906
Molecular Formula: C13H15NO5
Formula Weight: 265.26
MOL File: 13504-86-4.mol

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Z-CIS-HYP-OH Property

Boiling point:: 486.9±45.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.78±0.40(Predicted)
Appearance: White to off-white Solid
optical activity: -37.8°(C=0.01g/ml MEOH)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 242772
Product name: Z-L-cis-4-hydroxyproline 99+%
Packaging: 250mg
Price: $245
Updated: 2021/12/16

TRC

Product number: B194150
Product name: (2S,4S)-1-[(Benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylicacid
Packaging: 500mg
Price: $340
Updated: 2021/12/16

Usbiological

Product number: 279910
Product name: Z-L-cis-4-hydroxyproline
Packaging: 500mg
Price: $382
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-QA
Product name: (2S,4S)-1-[(Benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid
Purity: 97.0%
Packaging: 250mg
Price: $190
Updated: 2021/12/16

Matrix Scientific

Product number: 057249
Product name: (2S,4S)-1-(Benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
Purity: 98%
Packaging: 1g
Price: $240
Updated: 2021/12/16

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Z-CIS-HYP-OH Chemical Properties,Usage,Production

Synthesis

117811-78-6

13504-86-4

General procedure for the synthesis of (2S,4S)-N-Cbz-4-hydroxypyrrolidine-2-carboxylic acid from (2S,4R)-Cbz-4-methanesulfonyloxyproline methyl ester: firstly, 708 g of water and 337 g of 48% sodium hydroxide solution were added to 928 g of the crude product obtained by reference to Example 3. The temperature of the mixture was raised to 80°C and the reaction was ripened at this temperature for 3 hours. Upon completion of the maturation, the temperature was kept constant and 146 g of solvent was distilled under reduced pressure until the pressure was reduced to 13 kPa. Subsequently, the mixture was cooled to 20°C, 180 g of 48% sodium hydroxide solution was added and aged at 25°C for 12 hours. The amount of cis-Benzyloxycarbonyl-4-hydroxy-L-proline in the reaction solution was determined by analysis to be 2.19 mol (81.0% yield based on trans-4-hydroxy-L-proline). Next, 35 g of toluene was added to the hydrolysis reaction solution and the mixture was concentrated under reduced pressure at 7 kPa and 40 °C to distill 332 g of solvent. Then, 161 g of concentrated sulfuric acid was added dropwise to the concentrated solution and the pH was adjusted to 1.3. After acidic adjustment, 710 g of tetrahydrofuran and 354 g of water were added for layered separation. To the separated water layer, 356 g of tetrahydrofuran was added and the separation was performed again. All the separated tetrahydrofuran layers were combined and concentrated at 40 °C under reduced pressure at 26 kPa, resulting in 896 g of concentrate containing 2.12 mol of cis-Benzyloxycarbonyl-4-hydroxy-L-proline (90.2% yield) with a cis/trans ratio of 98.3/1.7.

References

[1] Patent: JP5703654, 2015, B2. Location in patent: Paragraph 0054; 0055

Z-CIS-HYP-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-CIS-HYP-OH Suppliers

China 61 Germany 2 India 1 Japan 2 United States 12 Global 78

Accela ChemBio Inc.

Tel: +1-858-6993322
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BOC Sciences

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Combi-Blocks Inc.

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SynQuest Laboratories, Inc.

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Matrix Scientific

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Chem-Impex International, Inc.

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View Lastest Price from Z-CIS-HYP-OH manufacturers

Career Henan Chemical Co

Product: Z-CIS-HYP-OH 13504-86-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-13

13504-86-4, Z-CIS-HYP-OHRelated Search:

Z-CYS(BZL)-OH Z-HYP-OH Z-D-PRO-OTBU H-D-CIS-HYP-OH FMOC-D-CIS-HYP-OH H-DL-cis-Hyp-OH CIS-4-HYDROXY-L-PROLINE[CIS-HYP-OH], Z-D-CIS-HYP-OH (S)-1-CBZ-2-HYDROXYMETHYLPYRROLIDINE H-L-CIS-HYP-OH,H-CIS-HYP-OH,CIS-HYP-OH Z-L-PROLINE Z-CIS-HYP-OH N-ME-CIS-HYP-OH CIS-ZHPROME (S)-1-CBZ-3-PYRROLIDINOL 95 3-HYDROXY-1-N-CBZ-PYRROLIDINE Z-D-ALA-OSU Z-D-ALA-GLY-OH

N-ALPHA-CARBOBENZOXY-CIS-4-HYDROXY-L-PROLINE

Z-L-CIS-4-HYDROXYPROLINE

cis-N-Cbz-4-hydroxy-L-proline

(2S,4S)-N-Cbz-trans-4-hydroxy-L-proline

Z-L-CIS-HYP-OH

Z-CIS-4-HYDROXY-L-PROLINE

Z-CIS-HYDROXYPROLINE

Z-CIS-HYP-OH

(2S,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

cis-N-alpha-Benzyloxycarbonyl-L-hydroxyproline, (2S,4S)-N-Benzyloxycarbonyl-4-hydroxy-2-pyrrolinecarboxylic acid

(2S,4S)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid hydrogen 1-(phenylmethyl) ester

1-(Benzyloxycarbonyl)-4α-hydroxy-L-proline

CIS-N-ALPHA-BENZYLOXYCARBONYL-L-HYDROXYPROLINE

(2S,4S)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic

(2S,4S)-4-hydroxy-1,2-Pyrrolidinedicarboxylic acid 1-(phenylmethyl) ester

Z-cis-L-Hyp-OH

Z-L-cis-4-hydroxyproline99%

CBZ-cis-Hyp-OH

N-Cbz-4-cis-Hydroxy-L-proline

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(phenylmethyl) ester, (2S,4S)-

(2S,4S)-1-(Benzyloxycarbonyl)-2-(carboxy)-4-hydroxypyrrolidine

(4S)-N-Cbz-4-hydroxy-D-proline

(2S, 4S)-l-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carbox

(2S,4S)-1-benzyloxycarbonyl-4-hydroxyproline

(2S,4S)-4-hydroxy-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid

(2S,4S)-N-Cbz-cis-4-hydroxy-L-proline

13504-86-4