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Salicylhydroxamic acid

Product Name
Salicylhydroxamic acid
CAS No.
89-73-6
Chemical Name
Salicylhydroxamic acid
Synonyms
SHAM;N,2-DIHYDROXYBENZAMIDE;sha;nsc5088;NSC 193440;AKOS BC-3099;Salicylhydroxamic;Salicylamide oxime;IFLAB-BB F1918-0014;alicylhydroxami acid
CBNumber
CB5357798
Molecular Formula
C7H7NO3
Formula Weight
153.14
MOL File
89-73-6.mol
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Salicylhydroxamic acid Property

Melting point:
177 °C (dec.) (lit.)
Boiling point:
276.03°C (rough estimate)
Density 
1.3585 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
Fine Crystalline Powder
pka
pK (25°) 4.19
color 
Beige-pink
Water Solubility 
It is soluble in water.
Merck 
14,8331
BRN 
1210520
Stability:
Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
CAS DataBase Reference
89-73-6(CAS DataBase Reference)
EPA Substance Registry System
N,2-Dihydroxybenzamide (89-73-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-40
Safety Statements 
22-26-36-24/25
WGK Germany 
3
RTECS 
VO6870000
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S607
Product name
Salicylhydroxamic acid
Purity
99%
Packaging
5g
Price
$49
Updated
2024/03/01
Sigma-Aldrich
Product number
S607
Product name
Salicylhydroxamic acid
Purity
99%
Packaging
25g
Price
$126
Updated
2024/03/01
TCI Chemical
Product number
S0008
Product name
Salicylhydroxamic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
S0008
Product name
Salicylhydroxamic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$65
Updated
2024/03/01
Alfa Aesar
Product number
A11528
Product name
Salicylhydroxamic acid, 99%
Packaging
10g
Price
$30.65
Updated
2024/03/01
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Salicylhydroxamic acid Chemical Properties,Usage,Production

Chemical Properties

It is a white needle crystal or off-white powder with a slow-heating melting point of 168°C. It is soluble in alcohol and ether and can be sublimated. When exposed to air, it progressively turns red. It is synthesized by combining methyl salicylate and hydroxylamine hydrochloride with sodium hydroxide, followed by acidification.

Uses

Salicylhydroxamic acid is a collector with efficient chelating effect on rare metal oxide minerals. It is used in rare metal beneficiation and has the advantages of good selectivity and strong collecting power. Salicylhydroxamic acid is mainly used as a complexing agent or extractant for rare earth ore, copper oxide ore, lead-zinc oxide ore, gold ore, kaolin, etc., as well as organic synthesis intermediates.

Definition

ChEBI: Salicylhydroxamic acid is a hydroxamic acid that is N-hydroxybenzamide carrying a phenolic hydroxy group at position 2. It has a role as an antibacterial drug, a trypanocidal drug, an EC 3.5.1.5 (urease) inhibitor and an EC 1.11.2.2 (myeloperoxidase) inhibitor. It is a member of phenols and a hydroxamic acid.

Application

Salicylhydroxamic acid has various applications, such as:
Synthesizing phenylboronic acid-based bioconjugates for chromatographic use.
Acting as a ligand to create complexes of Fe(III), Cu(II), Ni(II), and Zn(II).
Acting as a selective collector during the flotation technique for segregating oxide minerals.

Preparation

The synthesis of salicylhydroxamic acid involved a two-step process. In the first step, methyl salicylate was prepared by esterifying salicylic acid with methanol using 28g (0.2 mol) of salicylic acid, 81 ml of methanol, and 8 ml of concentrated sulfuric acid. In the second step, hydroxylamine was coupled with the methyl salicylate. 13.9 g (0.2mol) of hydroxylamine was mixed with 200 ml of 10% sodium hydroxide solution and cooled. To this, 152.3g (0.1mol) of methyl salicylate was added in small portions with vigorous shaking after each addition to ensure complete dissolution. The mixture was allowed to stand for 36 hours, then acidified with 2M sulphuric acid and cooled. The precipitate was filtered, recrystallized from hot water containing a drop of acetic acid, recooled, and filtered. The yield of white precipitate collected and weighed was 14g of salicylhydroxamic acid.
Preparation and Characterization of Salicylhydroxamic acid and its Complexes with Iron (III), Cobalt (II) and Manganese (II)

Purification Methods

Crystallise the hydroxamic acid from acetic acid. [Beilstein 10 H 98.]

Salicylhydroxamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Salicylhydroxamic acid manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Salicylhydroxamic acid 89-73-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-09-13
Hebei Mojin Biotechnology Co., Ltd
Product
Salicylhydroxamic acid 89-73-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-24
Hebei Guanlang Biotechnology Co., Ltd.
Product
Salicylhydroxamic acid 89-73-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-11-15

89-73-6, Salicylhydroxamic acidRelated Search:


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