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Prednisone 21-acetate

Product Name
Prednisone 21-acetate
CAS No.
125-10-0
Chemical Name
Prednisone 21-acetate
Synonyms
Ferr;nisone;Cblconin;d-Corlin;delcortin;deltalone;delta-corlin;PREDNISONE ACETATE;Prendnisone acetate;Prednisone 21-acetat
CBNumber
CB5360752
Molecular Formula
C23H28O6
Formula Weight
400.46
MOL File
125-10-0.mol
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Prednisone 21-acetate Property

Melting point:
240-242°C (dec.)
alpha 
D25 +186° (dioxane)
Boiling point:
582.0±50.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
12.31±0.60(Predicted)
color 
White to Off-White
Water Solubility 
23mg/L(25 ºC)
InChIKey
MOVRKLZUVNCBIP-RFZYENFJSA-N
SMILES
C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1=O)(C)[C@@](O)(C(=O)COC(C)=O)CC3)CC2
CAS DataBase Reference
125-10-0(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2955
Product name
Prednisone Acetate
Packaging
1G
Price
$96
Updated
2025/07/31
TCI Chemical
Product number
P2955
Product name
Prednisone Acetate
Packaging
5G
Price
$288
Updated
2025/07/31
TRC
Product number
P703825
Product name
Prednisone21-Acetate
Packaging
1g
Price
$1070
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
72104
Product name
Prednisone21-Acetate
Packaging
1g
Price
$1380
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003922
Product name
PREDNISONE ACETATE
Purity
95.00%
Packaging
1G
Price
$1593.9
Updated
2021/12/16
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Prednisone 21-acetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Adrenocortical steroid antiinflammatory.

Definition

ChEBI: Cortancyl is a steroid ester, a 20-oxo steroid, an acetate ester, a 17alpha-hydroxy steroid, an 11-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a prednisone.

in vivo

Prednisone acetate (5 mg/kg, Intragastric gavage, once a day for 4 weeks) induces hippocampal LTP impairment by causing neuronal lesions in the dentate gyrus, which reduced glutamic acid (Glu) and NMDAR2A, and impaired spatial memory in Hippocampal LTP impairment model mice[1].
Prednisone acetate (6 mg/kg, gavage, once a day for 15 days) reduces ocular and peripheral inflammatory responses and restores Th1/Th2 and Th17/Treg immune homeostasis through orchestrating the Notch signaling pathway in Experimental autoimmune uveitis (EAU) rats[2].

Animal Model:C57BL/6 mice [1]
Dosage:5 mg/kg
Administration:Intragastric gavage (i.g.)
Result:Significantly failed to gain weight. Decreased the population spike (%) after high-frequency stimulation. Reduced the crossing times compared with the control group. Resulted in the impairment of memory, and caused a trend of more serious impairment. Reduced the levels of Glu and gamma-aminobutyric acid (GABA) in the hippocampus. Reduced the expressions of N-methyl-D-aspartate receptors in the hippocampus.
Animal Model:Experimental autoimmune uveitis [2]
Dosage:6 mg/kg
Administration:gavage
Result:Showed fewer manifestations in eyes from day 9 after immunization. Reduced the inflammation in EAU rats. Bound with the pocket of Notch signaling-related molecules with good affinity. Exhibited anti-inflammatory effects through inhibiting Notch signaling activation. Decreased Th1, Th17 and increased Th2, Treg frequencies in EAU.

IC 50

IL-17; IL-10; IL-4

Prednisone 21-acetate Preparation Products And Raw materials

Raw materials

Selenium dioxide Cortisone acetate

Preparation Products

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Prednisone 21-acetate Suppliers

Canada 1 China 333 Czech 1 Europe 2 Germany 1 India 5 Russia 1 United Kingdom 7 United States 25 Global 376
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Prednisone 21-acetate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Prednisone 21-acetate / Dehydrocortisone acetate 125-10-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500
Release date
2023-07-31
Henan Suikang Pharmaceutical Co.,Ltd.
Product
Prednisone 21-acetate 125-10-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
1tons
Release date
2024-04-26
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Prednisone Acetate 125-10-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-25

125-10-0, Prednisone 21-acetateRelated Search:

Dimethyl disulfide Prednisone Meprednisone Dimethyl sulfate N,N-Dimethylformamide 2-Butoxyethyl acetate Prednisolone Dimethyl phthalate Dimethyl ether Dimethyl carbonate ETHANE Butyl acetate Sodium acetate Isopropyl acetate Dimethyl fumarate Ethylene glycol monoethyl ether acetate 1-Methoxy-2-propyl acetate Glatiramer acetate

  • 17 ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE-21-ACETATE
  • 1-DEHYDROCORTISONE ACETATE
  • 1,4-PREGNADIEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE
  • 1,4-PREGNADIEN-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE
  • [2-[(8s,9s,10s,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
  • Dehydrocortisone acetate
  • prednisone 21-acetate
  • PREDNISONE ACETATE
  • 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione-21-acetate
  • 17α,21-Dihydroxypregna-1,4-diene-3,11,20-trioneacetate
  • [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate
  • acetic acid [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-3,11-diketo-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester
  • Prednisone 21-acetat
  • 1-Cortisone 21-Acetate
  • 21-(Acetyloxy)-17-hydroxy-pregna-1,4-diene-3,11,20-trione
  • 11,20-trione,21-(acetyloxy)-17-hydroxy-pregna-4-diene-3
  • 4-diene-3,11,20-trione,17,21-dihydroxy-pregna-21-acetate
  • acetic acid [2-(17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] ester
  • Prednisone/ Prednisone Acetate
  • Prednisone EP Impurity E
  • delcortin
  • delta’-dehydrocortisoneacetate
  • delta-corlin
  • deltalone
  • nisone
  • ACETIC ACID 2-((8S,9S,10R,13S,14S,17R)-17-HYDROXY-10,13-DIMETHYL-3,11-DIOXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER
  • 21-Acetoxy-17α-hydroxypregna-1,4-diene-3,11,20-trione
  • Ferr
  • Pregna-1,4-diene-3,11,20-trione,21-(acetyloxy)-17-hydroxy-
  • Cblconin
  • Prednisone EP Impurity E (Prednisone 21-Acetate)
  • hot selling Prednisone 21-acetate
  • Prednisone 21-acetate USP/EP/BP
  • d-Corlin
  • Prednisone Impurity 6
  • Cortancyl (Prednisone 21-acetate)
  • 21-Acetoxy-17a-hydroxypregna-1,4-diene-3,11,20-trione (Prednisone Acetate)
  • Prednisone 21-acetate / Dehydrocortisone acetate
  • Prendnisone acetate
  • Alitretinoin Impurity 22
  • Prednisolone Impurity 32
  • Prednisone acetate, Glucocorticoid
  • Prednisone acetate, 10 mM in DMSO
  • 125-10-0
  • 125-10-2
  • C23H28O6
  • 40046
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • 125-10-0