Auranofin
- Product Name
- Auranofin
- CAS No.
- 34031-32-8
- Chemical Name
- Auranofin
- Synonyms
- Adtil;ridaura;Auranon;Crisinor;Crisofin;Ridauran;AURANOFIN;sk&f39162;sk&f39162d;AURANOFINE
- CBNumber
- CB5363410
- Molecular Formula
- C20H34AuO9PS
- Formula Weight
- 678.48
- MOL File
- 34031-32-8.mol
Auranofin Property
- Melting point:
- 112-115°
- storage temp.
- room temp
- solubility
- DMSO: ≥5mg/mL
- form
- solid
- color
- Crystals
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety
- Hazard Codes
- Xn
- Risk Statements
- 63-22
- Safety Statements
- 36/37
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- RTECS
- MD6500000
- Hazardous Substances Data
- 34031-32-8(Hazardous Substances Data)
- Toxicity
- LD50 in rats, mice (mg/kg): 265, 310 orally (Payne, Walz)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- A6733
- Product name
- Auranofin
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- A6733
- Product name
- Auranofin
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $459
- Updated
- 2024/03/01
- Product number
- 15316
- Product name
- Auranofin
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $51
- Updated
- 2024/03/01
- Product number
- 15316
- Product name
- Auranofin
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $82
- Updated
- 2024/03/01
- Product number
- 15316
- Product name
- Auranofin
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $303
- Updated
- 2024/03/01
Auranofin Chemical Properties,Usage,Production
Description
Auranofin is the first orally effective gold compound to be marketed for the treatment of severe rheumatoid arthritis. It is better tolerated and more convenient than gold sodium thiomalate, which is administered intramuscularly.
Chemical Properties
White to Off-White Solid
Originator
Smith Kleiu & French (USA)
Uses
Auranofin is a new oral gold-based antiarthritis drug. Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human m acrophages, basophils, and pulmonary mast cells. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of m itochondrial thioredoxin reductase.
Uses
Auranofin inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin also inhibits 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKβ subunit 5 and selenoenzyme thioredoxin reductase (TrxR) which is involved in the defense against oxidative stress. Auranofin is a disease-modifying antirheumatic drug (DMARD) and has been used to study the anti-proliferative effects against OVCAR-3 human ovarian carcinoma cells.
Definition
ChEBI: An S-glycosyl compound consisting of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose with the sufur atom coordinated to (triethylphosphoranylidene)gold. It is administered orally fo the treatment of active progressive rheumatoid arthritis.
Manufacturing Process
(A) Triethylphosphine gold chloride: A solution of 10.0 g (0.08 mol) of
thiodiglycol in 25 ml of ethanol is mixed with a solution of 15.76 g (0.04 mol)
of gold acid chloride trihydrate in 75 ml of distilled water. When the bright
orange-yellow solution is almost colorless, it is cooled to -5°C and an equally
cold solution of 5.0 g (0.0425 mol) of triethylphosphine in 25 ml of ethanol is
added dropwise to the stirred solution. After the addition is complete, the
cooled mixture is stirred for ? hour. Solid that separates is removed and the
filtrate is concentrated to about 30 ml to yield a second crop. The combined
solid is washed with aqueous-ethanol (2:1) and recrystallized from ethanol by
adding water to the cloud point. The product is obtained as white needles, MP
85° to 86°C.
(B) Auranofin: A cold solution of 1.66 g (0.012 mol) of potassium carbonate in 20 ml of distilled water is added to a solution of 5.3 g (0.011 mol) of S-
(2,3,4,6-tetra-O-acetylglucopyranosyl)-thiopseudourea hydrobromide
[Methods in Carbohydrate Chemistry, vol 2, page 435 (1963)] in 30 ml of
water at -10°C. A cold solution of 3.86 g (0.011 mol) of triethylphosphine
gold chloride in 30 ml of ethanol containing a few drops of methylene chloride
is added to the above mixture before hydrolysis of the thiouronium salt is
complete. After the addition is complete, the mixture is stirred in the cold for
? hour. The solid that separates is removed, washed first with aqueous
ethanol then water and dried in vacuum. There is obtained colorless crystals,
MP 110° to 111°C, of S-triethylphosphine gold 2,3,4,6-tetra-O-acetyl-1-thio-β-
D-glucopyranoside.
brand name
Ridaura (Promethus, Smith Kline Beecham, USA), Aktil (Lek, Yugoslavia), Ridauran (Robapharm, France).
Therapeutic Function
Antiarthritic
Pharmaceutical Applications
Auranofin ([tetra-O-acetyl-β-D- (glucopyranosyl)thio]-triethylphosphine)gold(I) is a second-generation gold-based drug, licensed as an orally available gold drug for the treatment of RA. It features a linear S Au P geometry, as shown by X-ray analysis. It is more lipophilic than the first-generation drugs, which makes oral administration possible. Treatment with Auranofin requires less visits to the clinic, but it is believed to be less successful in the treatment of RA compared to gold drugs being administered intramuscularly.
Biochem/physiol Actions
Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. The compound also inhibits 5-lipoxygenase in human neutrophils. Auranofin is a disease-modifying antirheumatic drug (DMARD). The compound is a potent inhibitor of selenoenzyme thioredoxin reductase (TrxR), which is involved in defense against oxidative stress. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase. Auranofin inhibits IKB kinase (IKK) by modifying Cys-179 of the IKKβ subunit 5.
Clinical Use
Auranofin is indicated in adults with active rheumatoid arthritis who have not responded sufficiently to one or more NSAIDs.
Safety Profile
Poison by ingestion,intraperitoneal, and intravenous routes. Human systemiceffects by ingestion: ulceration or bleeding from stomach.An experimental teratogen. Other experimentalreproductive effects. Human mutation data reported.When heated to decomp
Synthesis
Synthesis: ethanolic thiodiglycol is treated
first with aqueous gold(I) acid chloride trihydrate, then with ethanolic triethylphosphine to
give triethylphosphine gold(I) chloride, which is
added to an aqueous solution of S-(2,3,4,6-tetra-O-acetylglucopyranosyl)pseudothiourea hydrobromide and potassium carbonate to give the desired auranofin.
Veterinary Drugs and Treatments
Auranofin has been used to treat idiopathic polyarthritis and pemphigus foliaceous in dogs and cats. Several clinicians report that while auranofin may be less toxic, it also less efficacious than injectable gold (aurothioglucose).
Metabolism
On a mg gold/kg basis, it is reported to be as effective in the rat adjuvant arthritis assay as the parenterally effective drugs. Daily oral doses produce a rapid increase in kidney and blood gold levels for the first 3 days of treatment, with a more gradual increase on subsequent administration. Plasma gold levels are lower than those attained with parenteral gold compounds. The major route of excretion is via the urine. Auranofin may produce fewer adverse reactions than parenteral gold compounds, but its therapeutic efficacy also may be less.
References
1) Columbo et al. (1990), Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin; Biochem. Pharmacol., 39 285 2) Rigobello et al. (2002), Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative; Br. J. Pharmacol., 136 1162 3) Merck 14 878
Auranofin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Auranofin manufacturers
- Product
- Auranofin 34031-32-8
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-10-16
- Product
- Auranofin 34031-32-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-29
- Product
- Auranofin 34031-32-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-30