IONOMYCIN
- Product Name
- IONOMYCIN
- CAS No.
- 56092-81-0
- Chemical Name
- IONOMYCIN
- Synonyms
- Ionomycin from Streptomyces conglobatus;EM 94;SQ-23377;IONOMYCIN;SQ 23377, EM 94;Ionomycinefreeacid;IONOMYCIN (SQ23377);IONOMYCIN USP/EP/BP;Ionomycin, Free Base;Ionomycin Free Acid (85%)
- CBNumber
- CB5380046
- Molecular Formula
- C41H72O9
- Formula Weight
- 709.01
- MOL File
- 56092-81-0.mol
IONOMYCIN Property
- Boiling point:
- 817.2±65.0 °C(Predicted)
- Density
- 1.072±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble to 10 mM in Ethanol and to 10 mM in DMSO.
- form
- Waxy solid
- pka
- 4.77±0.10(Predicted)
- color
- Yellow
- BRN
- 3642126
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 36-36/37/39-27-26-24/25
- WGK Germany
- 3
- RTECS
- NO0650000
- F
- 8-10
- HazardClass
- 3
- HS Code
- 29419090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H225Highly Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- I9657
- Product name
- Ionomycin from Streptomyces conglobatus
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $197
- Updated
- 2024/03/01
- Product number
- 407950
- Product name
- Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem
- Purity
- Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+.
- Packaging
- 1mg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- 407951
- Product name
- Ionomycin, Free Acid,
- Packaging
- 1mg
- Price
- $190
- Updated
- 2024/03/01
- Product number
- 407950
- Product name
- Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem
- Purity
- Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+.
- Packaging
- 5mg
- Price
- $572
- Updated
- 2024/03/01
- Product number
- J62448
- Product name
- Ionomycin, 98%
- Packaging
- 1mg
- Price
- $87.8
- Updated
- 2023/06/20
IONOMYCIN Chemical Properties,Usage,Production
Description
Ionomycin (56092-81-0) is a highly selective nonfluorescent calcium (Ca2+) ionophore.1 Induces a rapid rise in cytosolic Ca2+ in human neutrophils which is due to both release from cytosolic Ca2+ stores as well as Ca2+ influx.2 It activates (2 μM) and primes (20-200 nM) neutrophil NADPH oxidase2. Down regulates beta-catenin/Tcf signaling in a colon cancer cell line via suppressing the binding of Tcf to its specific DNA-binding site.3 In rat hepatoma cells, sub-lethal ionomycin activates the stress response by activating SAPK/JNK and HSF/HSE interaction leading to upregulation of HSP70 biosynthesis.4
Chemical Properties
White powder
Uses
Ionomycin was isolated from Streptomyces conglobatus as a potent Gram positive antibiotic . During isolation, it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium ions, suggesting the metabolite acts as a calcium ionophore. More recently, ionomycin has been used in cell biology as a universal calcium ionophore to explore the role of calcium regulation in the cell.
Uses
Ionomycin is more effective than A23187 as a Ca++ionophore. Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons
Uses
Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.
Definition
ChEBI: A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at osition 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca2+ and as a research tool to understand Ca2+ transport across biological memb anes.
General Description
Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
Biological Activity
Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ).
Biochem/physiol Actions
Cell permeable: yes
in vitro
calcium ion can be extracted by ionomycin fom the queous phase into the organic phase. ionomycin also acts as a mobile ion carrier, which transports the cation across a solvent barrier [1].
in vivo
efficiency of ionomycin on oocyte activation and subsequent development was evaluated, which identified ionomycin as an efficient activator at the concentation of 10 μmol/l. with a second exposure to 5 μmol/l ionomycin on blastocyst development, an improved effect was found. no adverse effects of ionomycin on mouse embryo development were identified [2].
storage
-20°C
References
1) Kaufmann et al., (1980), Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria; J. Biol. Chem. 255 2735 2) Elzi et al., (2001), Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils; Am. J. Physiol. Cell Physiol. 281 C350 3) Park et al., (2005), Ionomycin downregulates beta-catenin/tcf signaling in colon cancer cell line; Carcinogenesis, 26 1929 4) Sreedhar and Srinivas (2002), Activation of stress response by ionomycin in rat hepatoma cells; J. Cell Biochem., 86 154
IONOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IONOMYCIN manufacturers
- Product
- IONOMYCIN 56092-81-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-16