IONOMYCIN CALCIUM SALT
- Product Name
- IONOMYCIN CALCIUM SALT
- CAS No.
- 56092-82-1
- Chemical Name
- IONOMYCIN CALCIUM SALT
- Synonyms
- ATCC 31005;Ionomycin,Ion;IONOMYCIN (CA);SQ23377 calcium;IONOMYCIN CA-SALT;ionomycin calcium;Calcium ionomycin.;Ionomycin Ca2+ salt;IONOMYCIN CALCIUM SALT;IONOMYCIN CALCIUM SALT 1MG
- CBNumber
- CB9458893
- Molecular Formula
- C41H70CaO9
- Formula Weight
- 747.07
- MOL File
- 56092-82-1.mol
IONOMYCIN CALCIUM SALT Property
- Melting point:
- 205-206 C
- Flash point:
- 87 °C
- storage temp.
- −20°C
- solubility
- Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol
- form
- White to off-white solid
- color
- white to off-white
- Sensitive
- Light Sensitive
- BRN
- 1416163
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I0634
- Product name
- Ionomycin calcium salt from Streptomyces conglobatus
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $163
- Updated
- 2024/03/01
- Product number
- I0634
- Product name
- Ionomycin calcium salt from Streptomyces conglobatus
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $711
- Updated
- 2024/03/01
- Product number
- 407952
- Product name
- Ionomycin, Calcium Salt, Streptomyces conglobatus - CAS 56092-82-1 - Calbiochem
- Purity
- Ionomycin, Calcium Salt, Streptomyces conglobatus, CAS 56092-82-1, is useful in cell activation experiments when calcium dose-response data are not required.
- Packaging
- 5mg
- Price
- $470
- Updated
- 2022/05/15
- Product number
- J67343
- Product name
- Ionomycin calcium salt, 1 mg/ml in methanol, sterile-filtered
- Packaging
- 1ml
- Price
- $423
- Updated
- 2024/03/01
- Product number
- J60628
- Product name
- Ionomycin calcium salt, 99%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2023/06/20
IONOMYCIN CALCIUM SALT Chemical Properties,Usage,Production
Description
Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 μM. Ionomycin (5 μM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; ) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro.
Chemical Properties
Powder
Uses
Ionomycin is more effectivethan A23187 as a Ca++ionophore; Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons.
Uses
Ionomycin calcium salt is used as a polyether antibiotic and apoptotic degeneration inducer. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration.
General Description
Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953).
Biological Activity
Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ).
Biochem/physiol Actions
Product does not compete with ATP.
storage
-20°C
References
Liu et al. (1978), Ionomycin, a new polyether antibiotic; J. Antibiot., 31 815 Liu and Hermann et al. (1978), Characterization of ionomycin as a calcium ionophore; J. Biol.Chem, 253 5892
IONOMYCIN CALCIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IONOMYCIN CALCIUM SALT manufacturers
- Product
- IONOMYCIN CALCIUM SALT 56092-82-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25