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IONOMYCIN CALCIUM SALT

Product Name
IONOMYCIN CALCIUM SALT
CAS No.
56092-82-1
Chemical Name
IONOMYCIN CALCIUM SALT
Synonyms
ATCC 31005;Ionomycin,Ion;IONOMYCIN (CA);SQ23377 calcium;IONOMYCIN CA-SALT;ionomycin calcium;Calcium ionomycin.;Ionomycin Ca2+ salt;IONOMYCIN CALCIUM SALT;IONOMYCIN CALCIUM SALT 1MG
CBNumber
CB9458893
Molecular Formula
C41H70CaO9
Formula Weight
747.07
MOL File
56092-82-1.mol
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IONOMYCIN CALCIUM SALT Property

Melting point:
205-206 C
Flash point:
87 °C
storage temp. 
−20°C
solubility 
Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol
form 
White to off-white solid
color 
white to off-white
Sensitive 
Light Sensitive
BRN 
1416163
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
NO0650000
HazardClass 
3
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I0634
Product name
Ionomycin calcium salt from Streptomyces conglobatus
Purity
powder, ≥98% (HPLC)
Packaging
1mg
Price
$163
Updated
2024/03/01
Sigma-Aldrich
Product number
I0634
Product name
Ionomycin calcium salt from Streptomyces conglobatus
Purity
powder, ≥98% (HPLC)
Packaging
5mg
Price
$711
Updated
2024/03/01
Sigma-Aldrich
Product number
407952
Product name
Ionomycin, Calcium Salt, Streptomyces conglobatus - CAS 56092-82-1 - Calbiochem
Purity
Ionomycin, Calcium Salt, Streptomyces conglobatus, CAS 56092-82-1, is useful in cell activation experiments when calcium dose-response data are not required.
Packaging
5mg
Price
$470
Updated
2022/05/15
Alfa Aesar
Product number
J67343
Product name
Ionomycin calcium salt, 1 mg/ml in methanol, sterile-filtered
Packaging
1ml
Price
$423
Updated
2024/03/01
Alfa Aesar
Product number
J60628
Product name
Ionomycin calcium salt, 99%
Packaging
5mg
Price
$193
Updated
2023/06/20
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IONOMYCIN CALCIUM SALT Chemical Properties,Usage,Production

Description

Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 μM. Ionomycin (5 μM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; ) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro.

Chemical Properties

Powder

Uses

Ionomycin is more effectivethan A23187 as a Ca++ionophore; Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons.

Uses

Ionomycin calcium salt is used as a polyether antibiotic and apoptotic degeneration inducer. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration.

General Description

Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953).

Biological Activity

Calcium ionophore; more specific than A23187 (5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid ).

Biochem/physiol Actions

Product does not compete with ATP.

storage

-20°C

References

Liu et al. (1978), Ionomycin, a new polyether antibiotic; J. Antibiot., 31 815 Liu and Hermann et al. (1978), Characterization of ionomycin as a calcium ionophore; J. Biol.Chem, 253 5892

IONOMYCIN CALCIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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IONOMYCIN CALCIUM SALT Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
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Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
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Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
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58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
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Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
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55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
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View Lastest Price from IONOMYCIN CALCIUM SALT manufacturers

Career Henan Chemical Co
Product
IONOMYCIN CALCIUM SALT 56092-82-1
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

56092-82-1, IONOMYCIN CALCIUM SALTRelated Search:


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