ChemicalBook > CAS DataBase List > Trichlormethiazide

Trichlormethiazide

Product Name
Trichlormethiazide
CAS No.
133-67-5
Chemical Name
Trichlormethiazide
Synonyms
TRICLORMETIAZIDA;TRICHLOROMETHIAZIDE;Naqua;Flurese;Naquival;Metahydrin;Navis;Nydor;Nakva;Natril
CBNumber
CB5407444
Molecular Formula
C8H8Cl3N3O4S2
Formula Weight
380.66
MOL File
133-67-5.mol
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Trichlormethiazide Property

Melting point:
248-250℃
Boiling point:
631.3±65.0 °C(Predicted)
Density 
1.748
refractive index 
1.6000 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
pKa 6.9(acetone/H2O) (Uncertain)
color 
White to Off-White
Merck 
14,9624
CAS DataBase Reference
133-67-5(CAS DataBase Reference)
EPA Substance Registry System
Trichlormethiazide (133-67-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
36
WGK Germany 
2
RTECS 
DK8925000
HS Code 
2935904000
Hazardous Substances Data
133-67-5(Hazardous Substances Data)
Toxicity
LD50 orally in rats: >20000 mg/kg (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1681000
Product name
Trichlormethiazide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$358
Updated
2024/03/01
TCI Chemical
Product number
T1318
Product name
Trichloromethiazide
Purity
>99.0%(T)
Packaging
10g
Price
$204
Updated
2024/03/01
Cayman Chemical
Product number
29331
Product name
Trichlormethiazide
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29331
Product name
Trichlormethiazide
Packaging
5g
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
29331
Product name
Trichlormethiazide
Packaging
10g
Price
$169
Updated
2024/03/01
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Trichlormethiazide Chemical Properties,Usage,Production

Chemical Properties

Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.

Originator

Naqua,Schering,US,1960

Uses

diuretic, antihypertensive

Uses

Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.

Uses

Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).

Definition

ChEBI: Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.

Manufacturing Process

A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.

Therapeutic Function

Diuretic

Trichlormethiazide Preparation Products And Raw materials

Raw materials

Preparation Products

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Trichlormethiazide Suppliers

China 142 Germany 3 India 5 Japan 1 South Korea 1 Switzerland 1 United Kingdom 3 United States 27 Global 183
J & K SCIENTIFIC LTD.
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View Lastest Price from Trichlormethiazide manufacturers

Hebei Miaoyin Technology Co.,Ltd
Product
Trichlormethiazide 133-67-5
Price
US $20.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000
Release date
2023-04-13
Hebei Yanxi Chemical Co., Ltd.
Product
Trichlormethiazide 133-67-5
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-18
Shaanxi Franta Biotechnology Co., Ltd
Product
Trichlormethiazide 133-67-5
Price
US $20.00/kg
Min. Order
1kg
Purity
99
Supply Ability
1000kg
Release date
2024-03-28

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