ChemicalBook > CAS DataBase List > 3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE

3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE

Product Name
3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE
CAS No.
16154-72-6
Chemical Name
3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE
Synonyms
Albb-005529;AKOS B033196;AKOS BB-7856;ASISCHEM Z03257;TIMTEC-BB SBB011555;3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE;3-chloro-4-(4-methyl-1-piperazinyl)aniline;1-(4-AMINO-2-CHLOROPHENYL)-4-METHYLPIPERAZINE;3-chloro-4-(4-methylpiperazin-1-yl)benzenamine;BENZENAMINE, 3-CHLORO-4-(4-METHYL-PIPERAZINYL)
CBNumber
CB5410099
Molecular Formula
C11H16ClN3
Formula Weight
225.72
MOL File
16154-72-6.mol
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3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE Property

Melting point:
141 °C
Boiling point:
382.1±42.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C, protect from light
pka
7.54±0.42(Predicted)
Appearance
Off-white to gray Solid
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
C367733
Product name
3-Chloro-4-(4-methylpiperazin-1-yl)aniline
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA02588
Product name
1-(4-Amino-2-chlorophenyl)-4-methylpiperazine
Packaging
500mg
Price
$100
Updated
2021/12/16
AK Scientific
Product number
N485
Product name
1-(4-Amino-2-chlorophenyl)-4-methylpiperazine
Packaging
1g
Price
$126
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA02588
Product name
1-(4-Amino-2-chlorophenyl)-4-methylpiperazine
Packaging
1g
Price
$170
Updated
2021/12/16
Matrix Scientific
Product number
008154
Product name
3-Chloro-4-(4-methyl-piperazin-1-yl)-phenylamine
Packaging
500mg
Price
$208
Updated
2021/12/16
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3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE Chemical Properties,Usage,Production

Synthesis

16154-62-4

16154-72-6

General procedure for the synthesis of 1-(4-amino-2-chlorophenyl)-4-methylpiperazine from 1-(2-chloro-4-nitrophenyl)-4-methylpiperazine: 1-(2-chloro-4-nitrophenyl)-4-methylpiperazine (13.5 g, 52.8 mmol) was dissolved in methanol (200 mL) and platinum(IV) oxide (0.120 g, 0.528 mmol) was added as catalyst. The reaction system was evacuated and replaced twice with hydrogen, and then the reaction was stirred under hydrogen atmosphere for 48 hours. After completion of the reaction, the crude reaction mixture was filtered through a diatomaceous earth pad and the filter cake was washed with methanol. The filtrate was concentrated to give 1-(4-amino-2-chlorophenyl)-4-methylpiperazine as an orange solid (12 g, 100% yield). The product was characterized by 1H NMR (400 MHz, methanol-d4): δ 2.35 (s, 3H), 2.62 (br.s., 4H), 2.95 (br.s., 4H), 6.63 (dd, J = 8.53, 2.76 Hz, 1H), 6.75-6.81 (m, 1H), 6.90-6.97 (m, 1H); the mass spectra (MS ) showed m/z 226 ([M+H]+).

References

[1] Patent: WO2011/120026, 2011, A1. Location in patent: Page/Page column 35
[2] Patent: WO2016/22460, 2016, A1. Location in patent: Page/Page column 138
[3] Patent: WO2017/66428, 2017, A1. Location in patent: Page/Page column 250

3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
3-chloro-4-(4-methylpiperazin-1-yl)aniline 16154-72-6
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2025-04-14

16154-72-6, 3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINERelated Search:

3-chloro-2-(4-methylpiperazin-1-yl)aniline 5-CHLORO-2-(4-METHYLPIPERAZIN-1-YL)ANILINE TIMTEC-BB SBB006244 Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- BUTTPARK 83\09-70 3-CHLORO-4-(4-ETHYL-PIPERAZIN-1-YL)-PHENYLAMINE [4-(4-AMINO-2-CHLORO-PHENYL)-PIPERAZIN-1-YL]-(4-PROPOXY-PHENYL)-METHANONE [4-(4-AMINO-2-CHLORO-PHENYL)-PIPERAZIN-1-YL]-O-TOLYL-METHANONE 2-[4-(2-CHLORO-4-NITROPHENYL)PIPERAZIN-1-YL]ETHANOL 3-CHLORO-4-[4-(2-CHLORO-BENZYL)-PIPERAZIN-1-YL]-PHENYLAMINE 1-[4-(4-AMINO-2-CHLORO-PHENYL)-PIPERAZIN-1-YL]-2-METHYL-PROPAN-1-ONE 3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE 3-CHLORO-4-[4-(THIEN-2-YLCARBONYL)PIPERAZIN-1-YL]ANILINE [4-(4-AMINO-2-CHLORO-PHENYL)-PIPERAZIN-1-YL]-PHENYL-METHANONE [4-(4-AMINO-2-CHLORO-PHENYL)-PIPERAZIN-1-YL]-(4-CHLORO-PHENYL)-METHANONE

  • 3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE
  • 3-CHLORO-4-(4-METHYL-PIPERAZIN-1-YL)-PHENYLAMINE
  • AKOS BB-7856
  • AKOS B033196
  • 1-(4-AMINO-2-CHLOROPHENYL)-4-METHYLPIPERAZINE
  • ASISCHEM Z03257
  • TIMTEC-BB SBB011555
  • BENZENAMINE, 3-CHLORO-4-(4-METHYL-PIPERAZINYL)
  • 3-chloro-4-(4-methyl-1-piperazinyl)aniline
  • Albb-005529
  • 3-chloro-4-(4-methylpiperazin-1-yl)benzenamine
  • 3-chloro-4-(4-methyl-1-piperazinyl)aniline trihydrochloride
  • Benzenamine, 3-chloro-4-(4-methyl-1-piperazinyl)-
  • 3-Chloro-4-(4-methylpiperazin-1-yl)benzenamine - [C28653]
  • 16154-72-6
  • C11H16ClN3
  • C11H16N3Cl
  • Miscellaneous