ChemicalBook > CAS DataBase List > 2,4,6-Trimethylaniline

2,4,6-Trimethylaniline

Product Name
2,4,6-Trimethylaniline
CAS No.
88-05-1
Chemical Name
2,4,6-Trimethylaniline
Synonyms
MESIDINE;MESITYLAMINE;2,4,6-trimethylbenzenamine;Mesidin;Mezidine;MESIDENE;AMINOMESITYLENE;Isotritoluidine;2-AMINOMESITYLENE;AKOS BBS-00003561
CBNumber
CB5410640
Molecular Formula
C9H13N
Formula Weight
135.21
MOL File
88-05-1.mol
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2,4,6-Trimethylaniline Property

Melting point:
-5 °C
Boiling point:
108-110 °C11 mm Hg(lit.)
Density 
0.963 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.551(lit.)
Flash point:
205 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
pK1:4.38(+1) (25°C)
form 
liquid (clear)
color 
clear brown
Water Solubility 
IMMISCIBLE
BRN 
636559
InChIKey
KWVPRPSXBZNOHS-UHFFFAOYSA-N
CAS DataBase Reference
88-05-1(CAS DataBase Reference)
IARC
3 (Vol. 27, Sup 7) 1987
NIST Chemistry Reference
Benzenamine, 2,4,6-trimethyl-(88-05-1)
EPA Substance Registry System
2,4,6-Trimethylaniline (88-05-1)
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Safety

Hazard Codes 
T+,T
Risk Statements 
21/22-26-36/38-33-23/24/25
Safety Statements 
26-28-36/37-45-28A
RIDADR 
UN 2810 6.1/PG 2
WGK Germany 
3
RTECS 
BZ0700000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214980
Hazardous Substances Data
88-05-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
132179
Product name
2,4,6-Trimethylaniline
Purity
98%
Packaging
25ml
Price
$47.2
Updated
2024/03/01
Sigma-Aldrich
Product number
132179
Product name
2,4,6-Trimethylaniline
Purity
98%
Packaging
100ml
Price
$52.8
Updated
2024/03/01
TCI Chemical
Product number
T0467
Product name
2,4,6-Trimethylaniline
Purity
>99.0%(GC)
Packaging
25mL
Price
$24
Updated
2024/03/01
TCI Chemical
Product number
T0467
Product name
2,4,6-Trimethylaniline
Purity
>99.0%(GC)
Packaging
100mL
Price
$47
Updated
2024/03/01
Alfa Aesar
Product number
A13049
Product name
2,4,6-Trimethylaniline, 98%
Packaging
100g
Price
$52.2
Updated
2024/03/01
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2,4,6-Trimethylaniline Chemical Properties,Usage,Production

Chemical Properties

clear yellow to brown liquid. Insoluble in water, soluble in organic solvents such as ethanol and ether.

Uses

2,4,6-Trimethylaniline is useful for the preparation of Grubbs' catalyst. It is used as a precursor to dyes. It undergoes condensation reaction with glyoxal to prepare glyoxal-bis(mesitylimine). It is also involved in the preparation of 1,3-diketimines ligands by condensation with 1,3-diketones. Further, it is used for the production of Acid Blue 129 dye, which is useful in histochemistry studies. In addition to this, it serves as a building block to various bulky ligands.

Preparation

2,4,6-Trimethylaniline is prepared by selective mononitration of mesitylene, avoiding oxidation of the methyl groups.
Mix sulfuric acid and nitric acid into mixed acid, nitrify with mesitylene at atmospheric pressure below 10°C for 4 hours, stand for stratification, and let off the waste acid. The obtained 2,4,6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were prepared in a ratio of 1:3.74:0.9:2.22 (mol ratio) for reduction reaction at 100-105°C for 8h. Crude 2,4,6-Trimethylaniline was then distilled off from the reduced material and purified by distillation.

Definition

ChEBI: 2,4,6-Trimethylaniline is a substituted aniline.

General Description

2,4,6-Trimethylaniline is a clear liquid. easily turns light brown when exposed to air and light. It is an intermediate for dyes, organic pigments and pesticides.

Reactivity Profile

2,4,6-Trimethylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

2,4,6-Trimethylaniline is moderately toxic orally. It is also considered highly toxic by unspecified routes. It is a skin and eye irritant. Suspect occupational carcinogen. (Non-Specific -- Aromatic Amines) The danger of acute poisoning is represented by methemoglobinemia leading to adverse effects on the red cells. A number of the amines may act as skin sensitizers.

Fire Hazard

When heated to decomposition, 2,4,6-Trimethylaniline emits toxic fumes of nitrogen oxides. Avoid decomposing heat.

Safety Profile

Poison by inhalation. Moderately toxic by ingestion. A skin and severe eye irritant. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

Used on small scale in organic synthesis.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

2,4,6-Trimethylaniline Preparation Products And Raw materials

Raw materials

nitrotoluene Mesitylene

Preparation Products

Acid Blue 129 CAFENSTROLE Solvent Blue 104 Tracid Light Yellow G ACID BLUE 80
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2,4,6-Trimethylaniline Suppliers

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View Lastest Price from 2,4,6-Trimethylaniline manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2,4,6-Trimethylaniline 88-05-1
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
2,4,6-Trimethylaniline 88-05-1
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21
Hebei Yalin Technology Co., Ltd
Product
2,4,6-Trimethylaniline 88-05-1
Price
US $0.00/vial
Min. Order
10vial
Purity
99.99%
Supply Ability
90000kit
Release date
2023-12-12

88-05-1, 2,4,6-TrimethylanilineRelated Search:

POLYANILINE N,N-Dimethyl-1,4-phenylenediamine Diphenylamine 4-Aminobenzotrifluoride Benzidine 3,3',5,5'-Tetramethylbenzidine dihydrochloride 1,3,5-Benzenetricarboxylic acid chloride 3,4,5-Trimethoxyaniline N-Methylaniline Aniline N,N-Dimethylaniline 2-Aminobenzotrifluoride o-Toluidine 4-Nitroaniline Tetramethylbenzidine N,N-Dimethyl-p-toluidine 2,4,6-TRI-TERT-BUTYLNITROSOBENZENE 3,5-DIMETHYL-4-NITROBENZOIC ACID

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  • AKOS BBS-00003561
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  • 2,4,6-TrimethylanilineHCl
  • 2,4,6-Trimethylanilinehydrochloride
  • 1-amino-2,4,6-trimethylbenzen(czech)
  • 1-Amino-2,4,6-trimethylbenzene
  • 2,4,6-trimethyl-anilin
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  • 2,4,6-Trimethylaniline &gt
  • Isotritoluidine
  • 88-05-1
  • 1988-05-1
  • 1988-5-1
  • 1988-05-01
  • CAS:88-5-1
  • C9H1N
  • CH32C6H3CH2NH2
  • CH33C6H2NH2
  • Organic Building Blocks
  • Nitrogen Compounds
  • Building Blocks
  • Amines
  • C9 to C10
  • API intermediates
  • Intermediates of Dyes and Pigments
  • bc0001