3,4,5-Trimethoxyaniline

Product Name: 3,4,5-Trimethoxyaniline
CAS No.: 24313-88-0
Chemical Name: 3,4,5-Trimethoxyaniline
Synonyms: 3,4,5-Trimethoxy;3,4,5-trimethoxy-benzenamin;3,4,5-triMethoxybenzenaMine;NSC 37006;TriMethoxyaniline;5-Trimethoxyaniline;3,4,5-TrimethoxyaniL;4,5-Trimethoxyaniline;3,4,5-TRIMETHOXYANILINE;3,4,5-TRIMOTHOXYANILINE
CBNumber: CB4117296
Molecular Formula: C9H13NO3
Formula Weight: 183.2
MOL File: 24313-88-0.mol

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3,4,5-Trimethoxyaniline Property

Melting point:: 110-113 °C (lit.)
Boiling point:: 316.88°C (rough estimate)
Density: 1.1967 (rough estimate)
refractive index: 1.4760 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.35±0.10(Predicted)
form: Powder
color: Off-white to beige-brown, gray, or pink
BRN: 642919
InChI: InChI=1S/C9H13NO3/c1-11-7-4-6(10)5-8(12-2)9(7)13-3/h4-5H,10H2,1-3H3
InChIKey: XEFRNCLPPFDWAC-UHFFFAOYSA-N
SMILES: C1(N)=CC(OC)=C(OC)C(OC)=C1
CAS DataBase Reference: 24313-88-0(CAS DataBase Reference)
EPA Substance Registry System: 3,4,5-Trimethoxyaniline (24313-88-0)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 37/38-36/37/38-20/21/22
Safety Statements: 22-24/25-37/39-26-24-36
RIDADR: 2811
WGK Germany: 3
Hazard Note: Harmful
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29222900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T68209
Product name: 3,4,5-Trimethoxyaniline
Purity: 97%
Packaging: 10g
Price: $60.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: T68209
Product name: 3,4,5-Trimethoxyaniline
Purity: 97%
Packaging: 25g
Price: $86.3
Updated: 2025/07/31

TCI Chemical

Product number: T1055
Product name: 3,4,5-Trimethoxyaniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: T1055
Product name: 3,4,5-Trimethoxyaniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $318
Updated: 2025/07/31

TRC

Product number: T795670
Product name: 3,4,5-Trimethoxyaniline
Packaging: 10g
Price: $70
Updated: 2021/12/16

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3,4,5-Trimethoxyaniline Chemical Properties,Usage,Production

Chemical Properties

3,4,5-Trimethoxyaniline is off-white to beige-brown, grey or pink powder

Uses

3,4,5-Trimethoxyaniline is a tri-substituted aniline derivative with sympatholytic activity. It is used in the preparation of a novel class of anticancer agents.

Application

3,4,5-Trimethoxyaniline can be used:
(1) As experimental studies, infrared spectra and laser Raman spectra of 3,4,5-trimethoxyaniline were investigated^[1].
(2) Tropanilisation, detropanilisation and Schiff base formation in the reaction of 3,4,5-trimethoxyaniline with tropanilide ions as organic reaction reagents^[2].

Application

[1] BANDANA SHARMA; Shweta P; Munish Kumar Yadav. MOLECULAR STRUCTURE, EXPERIMENTAL AND THEORETICAL (HF, DFT) SPECTRAL ANALYSIS OF 3,4,5- TRIMETHOXYANILINE[J]. Rasayan Journal of Chemistry, 2023. DOI:10.31788/rjc.2023.1628371.
[2] J. TSUNETSUGU; S. E; M SATO. ChemInform Abstract: TROPENYLATION, DETROPENYLATION AND SCHIFF BASE FORMATION IN THE REACTION OF 3,4,5-TRIMETHOXYANILINE WITH TROPENYLIUM ION[J]. ChemInform, 1975. DOI:10.1002/chin.197545221.

Synthesis

6307-90-0

24313-88-0

Step B / Intermediate B9: Synthesis of 3,4,5-trimethoxyaniline To a solution of 1,2,3-trimethoxy-5-nitrobenzene (6.64 g, 31.2 mmol) in ethanol (250 mL) was added palladium carbon (10%, 300 mg) and hydrazine hydrate (85%, 5.7 mL). The reaction mixture was heated to reflux for 1 hour after gas release ceased. Upon completion of the reaction, the mixture was cooled to room temperature and the catalyst was removed by filtration followed by evaporation of the solvent to afford 3,4,5-trimethoxyaniline (5.5 g, 96.4% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 5.86 (s, 2H), 4.82 (br, 2H), 3.64 (s, 6H), 3.50 (s, 3H).

References

[1] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 60
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 9, p. 3414 - 3425
[3] Chemische Berichte, 1888, vol. 21, p. 615
[4] Australian Journal of Scientific Research, Series A: Physical Sciences, 1950, vol. 3, p. 467,500
[5] Journal of Pharmacy and Pharmacology, 1958, vol. 10, p. 47,59

3,4,5-Trimethoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4,5-Trimethoxyaniline Suppliers

Belgium 2 Canada 1 China 242 Europe 2 France 1 Germany 6 India 26 Japan 3 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 13 United States 39 Global 339

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View Lastest Price from 3,4,5-Trimethoxyaniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,4,5-Trimethoxyaniline 24313-88-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-10

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3,4,5-Trimethoxyaniline 24313-88-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-18

Henan Aochuang Chemical Co.,Ltd.

Product: 3,4,5-Trimethoxyaniline 24313-88-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

24313-88-0, 3,4,5-TrimethoxyanilineRelated Search:

Trimethyl phosphite 4-(Trifluoromethoxy)aniline (Trifluoromethoxy)benzene 3-(Trifluoromethoxy)bromobenzene m-Anisidine p-Anisidine o-Anisidine 3,4,5-TRIMETHOXYPHENYL ISOTHIOCYANATE 1-(3,4,5-TRIMETHOXYPHENYL)-2-THIOUREA 3,4,5-TRIMETHOXYPHENYL ISOCYANATE Trimetrexate N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE 2,4,5-Trimethoxyaniline 1,2,3-TRIMETHOXY-5-NITROBENZENE 3,4,5-TRIMETHOXY-ACETOACETANILIDE 2-CHLORO-N-(3,4,5-TRIMETHOXYPHENYL)ACETAMIDE ASISCHEM C66342 4-(3,4,5-TRIMETHOXYPHENYL)-3-THIOSEMICARBAZIDE

3,4,5-TRIMOTHOXYANILINE

TriMethoxyaniline

3,4,5-TRIMETHOXYANILINE

3,4,5-TRIMETHOXYPHENYLAMINE

3,4,5-trimethoxy-benzenamin

3,4,5-Trimethoxy

3,4,5-Trimethoxyaniline 98%

Benzenamine, 3,4,5-trimethoxy-

3,4,5-Trimethoxyaniline,97%

3,4,5-TRIMETHOXYANILINE 98+%

4,5-Trimethoxyaniline

[3,4,5-Tris(Methyloxy)phenyl]aMine

3,4,5-Tris(Methyloxy)aniline

NSC 37006

3,4,5-triMethoxybenzenaMine

3,4,5-TriMethoxyaniline, 97% 10GR

3,4,5-TrimethoxyaniL

3,4,5-Trimethoxyaniline ISO 9001：2015 REACH

5-Trimethoxyaniline

24313-88-0

CH3O3C6H2NH2

AMINE

Building Blocks

Amines

C9 to C10

Organic Building Blocks

Nitrogen Compounds

amine

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Anilines, Aromatic Amines and Nitro Compounds

Amines

C9 to C10

Nitrogen Compounds