2,4,5-Trimethoxyaniline
- Product Name
- 2,4,5-Trimethoxyaniline
- CAS No.
- 26510-91-8
- Chemical Name
- 2,4,5-Trimethoxyaniline
- Synonyms
- 2,4,5-Trimethoxyanlline;2,4,5-Trimethoxyaniline;2,4,5-Trimethoxy-phenylamine;Benzenamine, 2,4,5-trimethoxy-;5-AMINO-1,2,4-TRIMETHOXYBENZENE;2,4,5-Trimethoxyaniline Hydrochloride
- CBNumber
- CB1947054
- Molecular Formula
- C9H13NO3
- Formula Weight
- 183.2
- MOL File
- 26510-91-8.mol
2,4,5-Trimethoxyaniline Property
- Melting point:
- 93-95 °C
- Boiling point:
- 305.5±37.0 °C(Predicted)
- Density
- 1.118±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 4.72±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T797330
- Product name
- 2,4,5-Trimethoxyaniline
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 2378AB
- Product name
- 2,4,5-Trimethoxyaniline
- Packaging
- 250mg
- Price
- $207
- Updated
- 2021/12/16
- Product number
- CHM0300814
- Product name
- 2,4,5-TRIMETHOXYANILINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.04
- Updated
- 2021/12/16
- Product number
- A146798
- Product name
- 2,4,5-Trimethoxyaniline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- 26510918
- Product name
- 2,4,5-Trimethoxyaniline
- Packaging
- 1g
- Price
- $284.2
- Updated
- 2021/12/16
2,4,5-Trimethoxyaniline Chemical Properties,Usage,Production
Chemical Properties
Crystallization. Melting point 93-95℃.
Uses
2,4,5-Trimethoxyaniline is used in preparation of Quinoline-5,8-dione derivatives as TGase 2 inhibitor.
Synthesis
14227-14-6
26510-91-8
The general procedure for the synthesis of 2,4,5-trimethoxyaniline from 1,2,4-trimethoxy-5-nitrobenzene was as follows: 103.0 g (0.4831 mol) of 1,2,4-trimethoxy-5-nitrobenzene, 7.5 g (0.0014 mol) of palladium-carbon catalyst (5.0% dry palladium content) and 0.82 g (0.0059 mol) of potassium carbonate were placed in a hydrogenation reactor and 723.6 g (8.2125 moles) of 1,4-dioxane was added as solvent. The reaction temperature was controlled between 75-85 °C, the stirring speed was maintained at 1400-1500 rpm, and the hydrogen pressure was maintained at 2.0-2.2 MPa, and the reaction was terminated after 1 hour. Upon completion of the reaction, the reaction mixture was filtered to recover the palladium-carbon catalyst. The filtrate was concentrated until a solid precipitated, 154.5 mL of toluene was added, the mixture was stirred and cooled to 5 °C and filtered to obtain a purple solid. The purple solid was dried under vacuum at 25-30 °C to give a final 84.3 g of 2,4,5-trimethoxyaniline. The yield of the catalytic hydrogenation reaction was 95.2%. The purity of the product was 98.0% by HPLC analysis, and the melting point was 94.2-95.0 °C, confirming the high purity of the resulting 2,4,5-trimethoxyaniline.
References
[1] Organic and Biomolecular Chemistry, 2004, vol. 2, # 20, p. 3039 - 3043
[2] Patent: CN107805204, 2018, A. Location in patent: Paragraph 0026-0030; 0031-0038; 0039-0052
[3] Journal of the American Chemical Society, 2011, vol. 133, # 41, p. 16418 - 16421
[4] Patent: US2003/236287, 2003, A1. Location in patent: Page 33, 34
[5] Patent: WO2004/46120, 2004, A2. Location in patent: Page 168
2,4,5-Trimethoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,5-Trimethoxyaniline manufacturers
- Product
- 2,4,5-Trimethoxyaniline 26510-91-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-02-21