ChemicalBook > CAS DataBase List > 3,4,5-Trimethoxyaniline

3,4,5-Trimethoxyaniline

Product Name: 3,4,5-Trimethoxyaniline
CAS No.: 24313-88-0
Chemical Name: 3,4,5-Trimethoxyaniline
Synonyms: 3,4,5-Trimethoxy;3,4,5-trimethoxy-benzenamin;3,4,5-triMethoxybenzenaMine;NSC 37006;TriMethoxyaniline;5-Trimethoxyaniline;3,4,5-TrimethoxyaniL;4,5-Trimethoxyaniline;3,4,5-TRIMETHOXYANILINE;3,4,5-TRIMOTHOXYANILINE
CBNumber: CB4117296
Molecular Formula: C9H13NO3
Formula Weight: 183.2
MOL File: 24313-88-0.mol

Less

3,4,5-Trimethoxyaniline Property

Melting point:: 110-113 °C (lit.)
Boiling point:: 316.88°C (rough estimate)
Density: 1.1967 (rough estimate)
refractive index: 1.4760 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 4.35±0.10(Predicted)
form: Powder
color: Off-white to beige-brown, gray, or pink
BRN: 642919
InChI: InChI=1S/C9H13NO3/c1-11-7-4-6(10)5-8(12-2)9(7)13-3/h4-5H,10H2,1-3H3
InChIKey: XEFRNCLPPFDWAC-UHFFFAOYSA-N
SMILES: C1(N)=CC(OC)=C(OC)C(OC)=C1
CAS DataBase Reference: 24313-88-0(CAS DataBase Reference)
EPA Substance Registry System: 3,4,5-Trimethoxyaniline (24313-88-0)

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 37/38-36/37/38-20/21/22
Safety Statements: 22-24/25-37/39-26-24-36
RIDADR: 2811
WGK Germany: 3
Hazard Note: Harmful
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29222900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T68209
Product name: 3,4,5-Trimethoxyaniline
Purity: 97%
Packaging: 10g
Price: $60.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: T68209
Product name: 3,4,5-Trimethoxyaniline
Purity: 97%
Packaging: 25g
Price: $86.3
Updated: 2025/07/31

TCI Chemical

Product number: T1055
Product name: 3,4,5-Trimethoxyaniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: T1055
Product name: 3,4,5-Trimethoxyaniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $318
Updated: 2025/07/31

TRC

Product number: T795670
Product name: 3,4,5-Trimethoxyaniline
Packaging: 10g
Price: $70
Updated: 2021/12/16

Less

3,4,5-Trimethoxyaniline Chemical Properties,Usage,Production

Chemical Properties

3,4,5-Trimethoxyaniline is off-white to beige-brown, grey or pink powder

Uses

3,4,5-Trimethoxyaniline is a tri-substituted aniline derivative with sympatholytic activity. It is used in the preparation of a novel class of anticancer agents.

Application

3,4,5-Trimethoxyaniline can be used:
(1) As experimental studies, infrared spectra and laser Raman spectra of 3,4,5-trimethoxyaniline were investigated^[1].
(2) Tropanilisation, detropanilisation and Schiff base formation in the reaction of 3,4,5-trimethoxyaniline with tropanilide ions as organic reaction reagents^[2].

Application

[1] BANDANA SHARMA; Shweta P; Munish Kumar Yadav. MOLECULAR STRUCTURE, EXPERIMENTAL AND THEORETICAL (HF, DFT) SPECTRAL ANALYSIS OF 3,4,5- TRIMETHOXYANILINE[J]. Rasayan Journal of Chemistry, 2023. DOI:10.31788/rjc.2023.1628371.
[2] J. TSUNETSUGU; S. E; M SATO. ChemInform Abstract: TROPENYLATION, DETROPENYLATION AND SCHIFF BASE FORMATION IN THE REACTION OF 3,4,5-TRIMETHOXYANILINE WITH TROPENYLIUM ION[J]. ChemInform, 1975. DOI:10.1002/chin.197545221.

Synthesis

6307-90-0

24313-88-0

Step B / Intermediate B9: Synthesis of 3,4,5-trimethoxyaniline To a solution of 1,2,3-trimethoxy-5-nitrobenzene (6.64 g, 31.2 mmol) in ethanol (250 mL) was added palladium carbon (10%, 300 mg) and hydrazine hydrate (85%, 5.7 mL). The reaction mixture was heated to reflux for 1 hour after gas release ceased. Upon completion of the reaction, the mixture was cooled to room temperature and the catalyst was removed by filtration followed by evaporation of the solvent to afford 3,4,5-trimethoxyaniline (5.5 g, 96.4% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 5.86 (s, 2H), 4.82 (br, 2H), 3.64 (s, 6H), 3.50 (s, 3H).

References

[1] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 60
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 9, p. 3414 - 3425
[3] Chemische Berichte, 1888, vol. 21, p. 615
[4] Australian Journal of Scientific Research, Series A: Physical Sciences, 1950, vol. 3, p. 467,500
[5] Journal of Pharmacy and Pharmacology, 1958, vol. 10, p. 47,59

3,4,5-Trimethoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3,4,5-Trimethoxyaniline Suppliers

Belgium 2 Canada 1 China 242 Europe 2 France 1 Germany 6 India 26 Japan 3 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 13 United States 39 Global 339

ChangShu Haitian Fine Chemicals Co.,Ltd

Tel: 13913622609
Fax: 86-512-52893680
Email: 974295387@qq.com
Country: China
ProdList: 192
Advantage: 61

Zhejiang zetian fine chemical co. LTD

Tel: 0571-87322520 18957127338
Fax: QQ:800182836
Email: sales@zetchem.com
Country: China
ProdList: 445
Advantage: 58

ITIC MEDCHEM(SUZHOU) CO.,LTD.

Tel: 0512-68323967 18015559028
Fax: +86-512-69200360
Email: sales@iticmedchem.com
Country: China
ProdList: 506
Advantage: 61

Zhejiang Karry Pharmachem Co., Ltd.

Tel: 19157666807
Email: info@karrypharma.com
Country: China
ProdList: 39
Advantage: 58

CHANGZHOU GARDE PHARMTECH CO.,LTD

Tel: 18006124028
Email: gardepharm@163.com
Country: China
ProdList: 117
Advantage: 58

Shanghai Chemilab Biotechnology CO.,Ltd

Tel: 18116465878
Email: kmlb@kaimilaibo.com
Country: China
ProdList: 2627
Advantage: 58

Nanjing Hengweisheng Pharmaceutical Technology Co., Ltd

Tel: 19941530336
Email: 3991044086@qq.com
Country: China
ProdList: 691
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Arbor Chemical Co., Ltd.

Tel: 021-60451683 15021268886
Fax: +86-21-60451682
Email: sales@arborchemical.com
Country: China
ProdList: 896
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3930
Advantage: 58

Shanghai Hao Yun Chemical Science Co.,Ltd.

Tel: 021-68367562 15002147577;
Fax: 021-68369562
Email: sales@haoyunchem.com
Country: China
ProdList: 457
Advantage: 55

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1839
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2965
Advantage: 60

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4924
Advantage: 55

Suzhou Lakestar Pharmatech Co., Ltd.

Tel: 0512-63970158-603 18018108880
Fax: 0512-63971078
Email: info@lakestarpharma.com
Country: China
ProdList: 421
Advantage: 59

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3852
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Hangzhou Dechem Tech Co.，Ltd

Tel: 86-0571-87649320
Fax: 86-0571-87649320
Email: dechem@aliyun.com
Country: China
ProdList: 162
Advantage: 58

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Less

View Lastest Price from 3,4,5-Trimethoxyaniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,4,5-Trimethoxyaniline 24313-88-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-10

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3,4,5-Trimethoxyaniline 24313-88-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-18

Henan Aochuang Chemical Co.,Ltd.

Product: 3,4,5-Trimethoxyaniline 24313-88-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

24313-88-0, 3,4,5-TrimethoxyanilineRelated Search:

Trimethyl phosphite 4-(Trifluoromethoxy)aniline (Trifluoromethoxy)benzene 3-(Trifluoromethoxy)bromobenzene m-Anisidine p-Anisidine o-Anisidine 3,4,5-TRIMETHOXYPHENYL ISOTHIOCYANATE 1-(3,4,5-TRIMETHOXYPHENYL)-2-THIOUREA 3,4,5-TRIMETHOXYPHENYL ISOCYANATE Trimetrexate N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE 2,4,5-Trimethoxyaniline 1,2,3-TRIMETHOXY-5-NITROBENZENE 3,4,5-TRIMETHOXY-ACETOACETANILIDE 2-CHLORO-N-(3,4,5-TRIMETHOXYPHENYL)ACETAMIDE ASISCHEM C66342 4-(3,4,5-TRIMETHOXYPHENYL)-3-THIOSEMICARBAZIDE

3,4,5-TRIMOTHOXYANILINE

TriMethoxyaniline

3,4,5-TRIMETHOXYANILINE

3,4,5-TRIMETHOXYPHENYLAMINE

3,4,5-trimethoxy-benzenamin

3,4,5-Trimethoxy

3,4,5-Trimethoxyaniline 98%

Benzenamine, 3,4,5-trimethoxy-

3,4,5-Trimethoxyaniline,97%

3,4,5-TRIMETHOXYANILINE 98+%

4,5-Trimethoxyaniline

[3,4,5-Tris(Methyloxy)phenyl]aMine

3,4,5-Tris(Methyloxy)aniline

NSC 37006

3,4,5-triMethoxybenzenaMine

3,4,5-TriMethoxyaniline, 97% 10GR

3,4,5-TrimethoxyaniL

3,4,5-Trimethoxyaniline ISO 9001：2015 REACH

5-Trimethoxyaniline

24313-88-0

CH3O3C6H2NH2

AMINE

Building Blocks

Amines

C9 to C10

Organic Building Blocks

Nitrogen Compounds

amine

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Anilines, Aromatic Amines and Nitro Compounds

Amines

C9 to C10

Nitrogen Compounds