ChemicalBook > CAS DataBase List > N-Hydroxyacetamidine

N-Hydroxyacetamidine

Product Name
N-Hydroxyacetamidine
CAS No.
22059-22-9
Chemical Name
N-Hydroxyacetamidine
Synonyms
acetamidoxime;METHYLAMIDOXIME;ACETAMIDE OXIME;Acetamidoxime >N-HYDROXYACETAMIDINE;ethylidyne amidoxime;Acetamide oxime, 95+%;N2-Hydroxyethanamidine;n-hydroxyethanimidamide;n-hydroxy-ethanimidamid
CBNumber
CB5431537
Molecular Formula
C2H6N2O
Formula Weight
74.08
MOL File
22059-22-9.mol
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N-Hydroxyacetamidine Property

Melting point:
134 °C
Boiling point:
110.6±23.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
7.48±0.69(Predicted)
form 
Powder, Crystals and/or Chunks
color 
White
InChI
InChI=1S/C2H6N2O/c1-2(3)4-5/h5H,1H3,(H2,3,4)
InChIKey
AEXITZJSLGALNH-UHFFFAOYSA-N
SMILES
C(NO)(=N)C
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39-37/39
RTECS 
AC6900000
HazardClass 
IRRITANT
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2646
Product name
Acetamidoxime
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$82
Updated
2025/07/31
TCI Chemical
Product number
A2646
Product name
Acetamidoxime
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$262
Updated
2025/07/31
TRC
Product number
H827803
Product name
N-Hydroxyacetamidine
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
H827803
Product name
N-Hydroxyacetamidine
Packaging
500mg
Price
$65
Updated
2021/12/16
TRC
Product number
H827803
Product name
N-Hydroxyacetamidine
Packaging
1g
Price
$75
Updated
2021/12/16
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N-Hydroxyacetamidine Chemical Properties,Usage,Production

Chemical Properties

White crystals

Uses

N-Hydroxyacetamidine is a useful research chemical used in the preparation of amidoximes and related compounds.

Synthesis

75-05-8

22059-22-9

The general procedure for the synthesis of N'-hydroxyacetamidine from acetonitrile is as follows:(a) Preparation of N-hydroxyacetamidine amide: Phenolphthalein (0.05 g) was added to a solution of hydroxylamine hydrochloride (35 g, 0.5 mol) in ethanol (200 ml) as an indicator. Sodium ethanol solution (324 ml, 21% v/v) was added slowly over a period of 1 hour. After 3 hours of reaction, acetonitrile (13.8 g) was added and the reaction was stirred at room temperature for 2 hours followed by heating at 40°C for 48 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered and the solvent was removed under reduced pressure. The residue was allowed to stand at room temperature for 48 h. Methanol (1 liter) was then added to dissolve the crude product and it was adsorbed onto silica. Purification by silica column chromatography using 9:1 dichloromethane:methanol as eluent gave the target product N'-hydroxyacetamidine (20.33 g, 81% yield). The product was characterized by 1H NMR (d6-DMSO): δ = 1.60 (3H, s), 5.33 (2H, br), 8.65 (1H, s).

References

[1] Patent: EP1157002, 2005, B1. Location in patent: Page/Page column 26
[2] Patent: WO2017/50969, 2017, A1. Location in patent: Page/Page column 14; 15
[3] Patent: WO2004/50650, 2004, A1. Location in patent: Page 103
[4] Patent: US2004/162276, 2004, A1. Location in patent: Page 22
[5] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 68

N-Hydroxyacetamidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Hydroxyacetamidine Suppliers

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View Lastest Price from N-Hydroxyacetamidine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Hydroxyacetamidine 22059-22-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Hydroxyacetamidine 22059-22-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
N-Hydroxyacetamidine 22059-22-9
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
100KG
Release date
2019-08-29

22059-22-9, N-HydroxyacetamidineRelated Search:

2'-Hydroxyacetophenone 1-Hydroxyethylidene-1,1-diphosphonic acid Hydroxy silicone oil 4'-Hydroxyacetophenone Acetamidine hydrochloride HYDROXYAPATITE TYPE I Glycolic acid 2-HYDROXYACETAMIDE 4-Hydroxybenzaldehyde Trifluoroacetamidine 2-AMINO-2-METHYL-PROPIONITRILE N-Hydroxysuccinimide N-Hydroxyphthalimide N-Hydroxysulfosuccinimide sodium salt 2-(4-FLUOROBENZYLSULFONYL)ACETAMIDOXIME 2-PIPERIDINOACETAMIDOXIME 2-Pyridylamid oxime (1E)-N'-HYDROXY-2-PHENYLETHANIMIDAMIDE

  • n-hydroxy-ethanimidamid
  • n-hydroxyethanimidamide
  • (1E)-N'-HYDROXYETHANIMIDAMIDE
  • ACETAMIDE OXIME
  • METHYLAMIDOXIME
  • ethylidyne amidoxime
  • N-HYDROXYACETAMIDINE
  • Acetamide oxime, 95+%
  • (1Z)-N'-hydroxyethanimidamide
  • 1-(Hydroxyamino)-1-ethanimine
  • 1-(Hydroxyimino)ethanamine
  • N2-Hydroxyethanamidine
  • ethanimidamide, N'-hydroxy-, (1Z)-
  • Acetamide oximeN-Hydroxyacetamide
  • (Z)-N'-hydroxyacetiMidaMide
  • (E)-N'-hydroxyacetiMidaMide
  • AcetaMide oxiMe, 95+% 1GR
  • AcetaMide oxiMe, 95+% 5GR
  • acetamidoxime
  • (3E)-3-(hydroxyiMino)propanaMide
  • Acetamidoxime &gt
  • Ethanimidamide, N-hydroxy- (9CI)
  • N'-Hydroxyacetimidamide
  • N'-hydroxyethanimidamide
  • N-Hydroxyacetamidine, 97%
  • N′-hydroxyethanimidamide, CAS 22059-22-9
  • 22059-22-9
  • CH3CNH2NOH
  • CH3CNOHNH2
  • pharmacetical