9H-PYRIDO[3,4-B]INDOLE

Product Name: 9H-PYRIDO[3,4-B]INDOLE
CAS No.: 244-63-3
Chemical Name: 9H-PYRIDO[3,4-B]INDOLE
Synonyms: NORHARMAN;NORHARMANE;β-carboline;BETA-CARBOLINE;B-CARBOLINE;Pyridoindole;NSC 8441;NSC 84417;9H-BETA-CA;CARBAZOLINE
CBNumber: CB5431618
Molecular Formula: C11H8N2
Formula Weight: 168.19
MOL File: 244-63-3.mol

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9H-PYRIDO[3,4-B]INDOLE Property

Melting point:: 199-201 °C
Boiling point:: 287.13°C (rough estimate)
Density: 1.1722 (rough estimate)
refractive index: 1.5200 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 15.44±0.30(Predicted)
form: crystalline
color: light yellow
Water Solubility: 2693g/L(17 ºC)
InChIKey: AIFRHYZBTHREPW-UHFFFAOYSA-N
LogP: 3.170
CAS DataBase Reference: 244-63-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36/37/39-26-22
RIDADR: 3261
WGK Germany: 3
RTECS: UU9350000
HS Code: 29339900
Toxicity: dnd-hmn:hla 50 mmol/L MUREAV 89,95,81

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N6252
Product name: Norharmane
Purity: crystalline
Packaging: 100mg
Price: $47.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: N6252
Product name: Norharmane
Purity: crystalline
Packaging: 1g
Price: $240
Updated: 2024/03/01

TCI Chemical

Product number: P1121
Product name: 9H-Pyrido[3,4-b]indole
Purity: >98.0%(GC)(T)
Packaging: 100mg
Price: $35
Updated: 2024/03/01

Cayman Chemical

Product number: 20043
Product name: Norharmane
Purity: ≥98%
Packaging: 250mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 20043
Product name: Norharmane
Purity: ≥98%
Packaging: 500mg
Price: $68
Updated: 2024/03/01

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9H-PYRIDO[3,4-B]INDOLE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

The compund has cytotoxic effects.

Uses

Used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

Definition

ChEBI: The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 2962, 1950 DOI: 10.1021/ja01163a041
Tetrahedron, 49, p. 49, 1993 DOI: 10.1016/S0040-4020(01)80505-6

Hazard

Toxic; nervous system effects.

Biological Activity

norharmane acts as a co-mutagen. norharmane is a natural β-carboline first isolated from plants of the zygophyllaceae family. it is a heterocyclic amine (hca) that may also be found in fried meats, tobacco smoke, and coffee. harman and norharmane are aminocarbolines known as “co-mutagens” because they do not show mutagenicity to salmonella serovar typhimurium [1][2][3].norharmane acts as a co-mutagen. norharmane is widely distributed in our environment. it was not mutagenic to salmonella typhimurium ta98 and ta100 either with or without s9 mix, but became mutagenic to s.typhimurium ta98 with s9 mix when non-mutagenic aromatic amines like aniline or o- or m-toluidine are added. also, norharmane and aromatic amines induced the formation of dna adduct in s.typhimurium ta98 [3].harman and norharmane with concentrations of 0.275 um and 0.9 um respectively might inhibited mao-a and mao-b. in adult male rats, a novel cocktail of cigarette smoke constituents, containing five minor alkaloids (nornicotine, cotinine, myosmine, anatabine, and anabasine), two β-carbolines (harman and norharmane), and acetaldehyde, did not significantly enhance nicotine self-administration [2].

Biochem/physiol Actions

Inhibitor of indoleamine 2,3-dioxygenase (IDO).

Safety Profile

Poison by intravenous route.Experimental reproductive effects. Human mutation datareported. When heated to decomposition it emits toxicfumes of NOx.

References

[1]. jamali ma, zhang y, teng h, et al. inhibitory effect of rosa rugosa tea extract on the formation of heterocyclic amines in meat patties at different temperatures. molecules. 2016 jan 30;21(2):173.
[2]. smith tt, schaff mb, rupprecht le, et al. effects of mao inhibition and a combination of minor alkaloids, β-carbolines, and acetaldehyde on nicotine self-administration in adult male rats. drug alcohol depend. 2015 oct 1;155:243-52.
[3]. mori m1, totsuka y, fukutome k, et al. formation of dna adducts by the co-mutagen norharman with aromatic amines. carcinogenesis. 1996 jul;17(7):1499-503.

9H-PYRIDO[3,4-B]INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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9H-PYRIDO[3,4-B]INDOLE Suppliers

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View Lastest Price from 9H-PYRIDO[3,4-B]INDOLE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 9H-PYRIDO[3,4-B]INDOLE 244-63-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-14

Career Henan Chemical Co

Product: 9H-PYRIDO[3,4-B]INDOLE 244-63-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-06

Career Henan Chemical Co

Product: 9H-PYRIDO[3,4-B]INDOLE 244-63-3
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 1000KG
Release date: 2018-08-10

244-63-3, 9H-PYRIDO[3,4-B]INDOLERelated Search:

SEMPERVIRINE NITRATE HARMANE ( 1-METHYL-9H-PYRIDO[3,4-B]INDOLE),Aribine~1-Methyl-9H-pyrido[3,4-b]indole n-methyl-9h-pyrido(3,4-b)indole-3-carboxamid 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl- 1-Methyl-9H-pyrido[3,4-b]indole.HCl,1-methyl-9H-pyrido[3,4-b]indole hydrochloride SERPENTINE HYDROGEN TARTRATE HARMINE HYDROCHLORIDE HARMOL HYDROCHLORIDE 3,4-dihydro-7-methoxy-1-methyl-9-pyrido(3,4-b)indol 3-AMINO-1,4-DIMETHYL-5H-PYRIDO[4,3-B]INDOLE, ACETATE 2-AMINO-9H-PYRIDO[2,3-B]INDOLE 2-amino-3-methyl-1h-pyrido(2,3-b)indol 3-AMINO-1-METHYL-5H-PYRIDO[4,3-B]INDOLE Chloropretadalafil 6-METHOXY-1,2,3,4-TETRAHYDRO-9H-PYRIDO-( 3,4B)INDOLE (MAO,2,3,4,9-tetrahydro-6-methoxy-1h-pyrido(3,4-b)indol 1H-Pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2-methyl-5-(phenylmethyl)-,5-Benzyl-1,3,4,5-tetrahydro-2-methyl-2H-pyrido[4,3-b]indole (1R,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-Methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate 1H-Pyrido[3,4-b]indole,2,3,4,9-tetrahydro

B-CARBOLINE

BETA-CARBOLINE

CARBAZOLINE

2,9-DIAZAFLUORENE

9H-BETA-CARBOLINE

9H-PYRIDO[3,4-B]INDOLE

PYRIDO(3,4-B)INDOLE

Pyridoindole

NORHARMANE FREE BASE

NORHARMAN 98%

NSC 8441

NSC 84417

Norharman,98%

NorharMan, 98% 500MG

beta-Carboline Norharman

Norharman, free base

NORHARMAN

NORHARMANE

2-azacarbazole

9H-β-Carboline

9H-BETA-CA

9H-Pyrido[3,4-b]indole&gt

β-carboline

9H-PYRIDO[3,4-B]INDOLE USP/EP/BP

9H-pyridine [3,4-b] indole

9H-Pyrido[3,4-b]indole , Norharmane

244-63-3

244-64-3

C6H4NHC6H10

Heterocycles

Mutagenesis Research Chemicals

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