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RHOEADINE

Product Name
RHOEADINE
CAS No.
2718-25-4
Chemical Name
RHOEADINE
Synonyms
rhoeadin;rheadine;RHOEADINE;Brn 0098745;(+)-Rheadine;Rheadine (8ci);RHODIZONIC ACID Dihydrate(RG);8β-Methoxy-16-methyl-2,3:10,11-bis[methylenebis(oxy)]rheadan;8-beta-methoxy-16-methyl-2,3:10,11-bis(methylenebis(oxy))rheadan;3:10,11-bis(methylenebis(oxy))-8-methoxy-16-methyl-(8-beta)-rheada
CBNumber
CB5435166
Molecular Formula
C21H21NO6
Formula Weight
383.4
MOL File
2718-25-4.mol
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RHOEADINE Property

Melting point:
222°C
alpha 
D23 +235° (c = 1.01 in chloroform); D22 +174° (c = 0.69 in pyridine)
Boiling point:
510.32°C (rough estimate)
Density 
1.3202 (rough estimate)
refractive index 
1.5614 (estimate)
pka
6.40±0.40(Predicted)
Water Solubility 
832.6mg/L(25 ºC)
LogP
3.920 (est)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
R317500
Product name
(+)-Rheadine
Packaging
10mg
Price
$4125
Updated
2021/12/16
TRC
Product number
R317500
Product name
(+)-Rheadine
Packaging
25mg
Price
$4950
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48577
Product name
(+)-Rheadine
Packaging
10mg
Price
$4750
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0032094
Product name
RHOEADINE
Purity
95.00%
Packaging
10MG
Price
$4908.75
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48577
Product name
(+)-Rheadine
Packaging
25mg
Price
$5500
Updated
2021/12/16
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RHOEADINE Chemical Properties,Usage,Production

Description

This alkaloid was found by Hesse in Papaver rhoeas Linn (red poppy) and its reputed existence in opium now appears doubtful. The base crystallizes from a mixture of CHCl3 and Et20 and sublimes at 21 5-225°C/0.02 mm. It has [α]17.5D + 232° (CHCI 3) or [α]19D + 243° (CHCl3). It behaves as a weak base and is sparingly soluble in H20, alkaline solutions and most organic solvents. It dissolves in mineral acids giving an intensely red solution but investigation shows that only a small proportion of the alkaloid is used to produce the colour, the major part being converted into a colourless, crystalline substance, Rhoeagenine, a much stronger base, non-volatile, and stable to acids. This base is not isomeric with the alkaloid as first thought but has the formula C2oH1906N, m.p. 236-8°C; [α]19D + l68° (AcOH).).
Rhoeadine itself contains two methylenedioxy groups, one methoxy group and an N-methyl group. The salts are not easy to prepare but a crystalline hydriodide dihydrate is formed by addition of KI to a solution of the alkaloid in AcOH. The ultraviolet spectrum of the alkaloid shows absorption maxima at 205, 240 and 292 mμ.

Uses

An isoquinoline alkaloid used in the therapeutic field particularly for the prevention and the treatment of pathologies implying a central and/or peripheral disorder.

Uses

As an isoquinoline alkaloid, Rhoeadine can be used in the therapeutic field particularly for the prevention and the treatment of pathologies implying a central and/or peripheral disorder.

Definition

ChEBI: Rhoeadine is an alkaloid.

References

Hesse., Annalen, Suppl., 4, 50 (1S65)
Hesse., ibid, 140, 145 (1S66)
Spath., Monatsh., 68,33 (1936)
Awe., Arch. Pharm., 279,116 (1941)
Santavy etat., Collect. Czech. Chem. Commun., 30,335,3479 (1965)
Mass spectrum:
Dolejs, Hanus., Tetrahedron, 23, 2997 (1967)
Stereochemistry:
Shamma et at., Chem. Commun., 212 (1968)

RHOEADINE Preparation Products And Raw materials

Raw materials

Preparation Products

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RHOEADINE Suppliers

Canada 1 China 16 Germany 2 India 1 United Kingdom 5 United States 6 Global 31
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-50135380
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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0086-21-51320502
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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China
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
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laboratory@coreychem.com
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Energy Chemical
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2718-25-4, RHOEADINERelated Search:

Isochroman 2-(Benzo[d][1,3]dioxol-5-yl)ethanol Phenylephrine INETERMEDIATE OF GALANTHAMINE 1 (R)-(-)-1-AMINO-1-PHENYL-2-METHOXYETHANE 4-CHLORO-2-FLUOROBENZYLAMINE HYDROCHLORIDE dioxethedrin (R)-4-(1-Aminoethyl)phenol (S)-hydroxybutanedioate salt 1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL Norepinephrine RHOEADINE etafedrine Synephrine (S)-(-)-1-(4-Methoxyphenyl)ethylamine 1-(1,3-BENZODIOXOL-5-YL)PROPAN-2-AMINE 1-(1,3-benzodioxol-5-yl)propan-1-amine (1R,2R)-(+)-2-AMINO-1,2-DIPHENYLETHANOL 2,2'-DIMETHYLBIBENZYL

  • 3:10,11-bis(methylenebis(oxy))-8-methoxy-16-methyl-(8-beta)-rheada
  • 8-beta-methoxy-16-methyl-2,3:10,11-bis(methylenebis(oxy))rheadan
  • rheadine
  • rhoeadin
  • RHOEADINE
  • (5bR,13bR,15S)-5b,6,7,8,13b,15-Hexahydro-15-Methoxy-6-Methyl-[1,3]dioxolo[4,5-h]-1,3-dioxolo[7,8][2]benzopyrano[3,4-a][3]benzazepine
  • 8β-Methoxy-16-methyl-2,3:10,11-bis[methylenebis(oxy)]rheadan
  • Brn 0098745
  • Rheadan, 8-methoxy-16-methyl-2,3:10,11-bis(methylenebis(oxy))-, (8-beta)-
  • Rheadine (8ci)
  • RHODIZONIC ACID Dihydrate(RG)
  • [1,3]Dioxolo[4,5-h]-1,3-dioxolo[7,8][2]benzopyrano[3,4-a][3]benzazepine, 5b,6,7,8,13b,15-hexahydro-15-methoxy-6-methyl-, (5bR,13bR,15S)-
  • (+)-Rheadine
  • 2718-25-4
  • Amines
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Alkaloids