2-Amino-5-nitrophenol
- Product Name
- 2-Amino-5-nitrophenol
- CAS No.
- 121-88-0
- Chemical Name
- 2-Amino-5-nitrophenol
- Synonyms
- 5-NITRO-2-AMINOPHENOL;2-HYDROXY-4-NITROANILINE;CI 76535;rodolyba;NSC 7087;ncic55970;Sulpho OAVS;ursolyellowbrowna;2-AMINO-5-NITROPENOL;2-AMINO-5-NITROPHENOL
- CBNumber
- CB5436138
- Molecular Formula
- C6H6N2O3
- Formula Weight
- 154.12
- MOL File
- 121-88-0.mol
2-Amino-5-nitrophenol Property
- Melting point:
- 198-202 °C (dec.) (lit.)
- Boiling point:
- 322.46°C (rough estimate)
- Density
- 1.3617 (estimate)
- refractive index
- 1.6890 (rough estimate)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 8.08±0.19(Predicted)
- color
- Rust brown to brown
- Water Solubility
- insoluble
- BRN
- 972974
- CAS DataBase Reference
- 121-88-0(CAS DataBase Reference)
- IARC
- 3 (Vol. 57) 1993
- EPA Substance Registry System
- 2-Amino-5-nitrophenol (121-88-0)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-68-20/21/22
- Safety Statements
- 26-36/37-45-36/37/39-36
- RIDADR
- 2811
- WGK Germany
- 2
- RTECS
- SJ6302500
- TSCA
- Yes
- HS Code
- 29222900
- Hazardous Substances Data
- 121-88-0(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: > 4gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 303585
- Product name
- 2-Amino-5-nitrophenol
- Packaging
- 100g
- Price
- $43.08
- Updated
- 2024/03/01
- Product number
- 303585
- Product name
- 2-Amino-5-nitrophenol
- Packaging
- 25g
- Price
- $51
- Updated
- 2024/03/01
- Product number
- N0113
- Product name
- 2-Amino-5-nitrophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $30
- Updated
- 2023/06/20
- Product number
- N0113
- Product name
- 2-Amino-5-nitrophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 500g
- Price
- $212
- Updated
- 2023/06/20
- Product number
- B20870
- Product name
- 2-Amino-5-nitrophenol, 96%
- Packaging
- 25g
- Price
- $31.5
- Updated
- 2023/06/20
2-Amino-5-nitrophenol Chemical Properties,Usage,Production
Chemical Properties
Brown to rust Crystalline powder
Uses
Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2
Uses
2-Amino-5-nitrophenol is used in hair dyes and as an intermediate in preparing azo dyes.
Uses
2-Amino-5-nitrophenol has been used as starting material in the synthesis of series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides, as semi permanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye products, in synthesis of series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones, anticonvulsant agents. Also used as a reactant for, diazotation and coupling reactions, preparation of biologically and pharmacologically active molecules. It is also applied in hair dyes and to make azo dyes.
Definition
ChEBI: 2-Amino-5-nitrophenol is a member of 3-nitrophenols.
General Description
Brown amorphous granules or powder. Melting point 198-202°C.
Air & Water Reactions
Is slowly oxidized by air at room temperature. Insoluble in water.
Reactivity Profile
2-Amino-5-nitrophenol is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides.
Fire Hazard
Flash point data for 2-Amino-5-nitrophenol are not available. 2-Amino-5-nitrophenol is probably combustible.
Carcinogenicity
The potential carcinogenicity of 2-amino-5-nitrophenol was tested by NTP by oral administration (gavage) in corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1 mice (400 and 800 mg/kg) for 2 years. There was some evidence of carcinogenic activity in low-dose male rats, as indicated by increased incidence of acinar cell adenomas of the pancreas. No evidence of carcinogenic activity was found among female rats and the low-dose groups of male and female mice. The poor survival rates in the high-dose male rats and high-dose male and female mice reduced the sensitivity for detecting potential carcinogenic response.
Purification Methods
Crystallise the phenol from water. [Beilstein 13 IV 803.]
2-Amino-5-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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