2-Amino-5-nitrophenol

Product Name: 2-Amino-5-nitrophenol
CAS No.: 121-88-0
Chemical Name: 2-Amino-5-nitrophenol
Synonyms: 5-NITRO-2-AMINOPHENOL;2-HYDROXY-4-NITROANILINE;CI 76535;rodolyba;NSC 7087;ncic55970;Sulpho OAVS;ursolyellowbrowna;2-AMINO-5-NITROPENOL;2-AMINO-5-NITROPHENOL
CBNumber: CB5436138
Molecular Formula: C6H6N2O3
Formula Weight: 154.12
MOL File: 121-88-0.mol

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2-Amino-5-nitrophenol Property

Melting point:: 198-202 °C (dec.) (lit.)
Boiling point:: 322.46°C (rough estimate)
Density: 1.3617 (estimate)
refractive index: 1.6890 (rough estimate)
solubility: DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: 8.08±0.19(Predicted)
color: Rust brown to brown
Water Solubility: insoluble
BRN: 972974
InChI: InChI=1S/C6H6N2O3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H,7H2
InChIKey: DOPJTDJKZNWLRB-UHFFFAOYSA-N
SMILES: C1(O)=CC([N+]([O-])=O)=CC=C1N
CAS DataBase Reference: 121-88-0(CAS DataBase Reference)
IARC: 3 (Vol. 57) 1993
EPA Substance Registry System: 2-Amino-5-nitrophenol (121-88-0)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-68-20/21/22
Safety Statements: 26-36/37-45-36/37/39-36
RIDADR: 2811
WGK Germany: 2
RTECS: SJ6302500
TSCA: Yes
HS Code: 29222900
Hazardous Substances Data: 121-88-0(Hazardous Substances Data)
Toxicity: LD50 oral in rat: > 4gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 303585
Product name: 2-Amino-5-nitrophenol
Packaging: 25g
Price: $49.97
Updated: 2025/07/31

Sigma-Aldrich

Product number: 303585
Product name: 2-Amino-5-nitrophenol
Packaging: 100g
Price: $70.3
Updated: 2025/07/31

TCI Chemical

Product number: N0113
Product name: 2-Amino-5-nitrophenol
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: N0113
Product name: 2-Amino-5-nitrophenol
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $212
Updated: 2025/07/31

TRC

Product number: A580130
Product name: 2-Amino-5-nitrophenol
Packaging: 5g
Price: $50
Updated: 2021/12/16

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2-Amino-5-nitrophenol Chemical Properties,Usage,Production

Chemical Properties

Brown to rust Crystalline powder

Uses

Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2

Uses

2-Amino-5-nitrophenol is used in hair dyes and as an intermediate in preparing azo dyes.

Uses

2-Amino-5-nitrophenol has been used as starting material in the synthesis of series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides, as semi permanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye products, in synthesis of series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones, anticonvulsant agents. Also used as a reactant for, diazotation and coupling reactions, preparation of biologically and pharmacologically active molecules. It is also applied in hair dyes and to make azo dyes.

Definition

ChEBI: 2-Amino-5-nitrophenol is a member of 3-nitrophenols.

General Description

Brown amorphous granules or powder. Melting point 198-202°C.

Air & Water Reactions

Is slowly oxidized by air at room temperature. Insoluble in water.

Reactivity Profile

2-Amino-5-nitrophenol is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides.

Fire Hazard

Flash point data for 2-Amino-5-nitrophenol are not available. 2-Amino-5-nitrophenol is probably combustible.

Carcinogenicity

The potential carcinogenicity of 2-amino-5-nitrophenol was tested by NTP by oral administration (gavage) in corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1 mice (400 and 800 mg/kg) for 2 years. There was some evidence of carcinogenic activity in low-dose male rats, as indicated by increased incidence of acinar cell adenomas of the pancreas. No evidence of carcinogenic activity was found among female rats and the low-dose groups of male and female mice. The poor survival rates in the high-dose male rats and high-dose male and female mice reduced the sensitivity for detecting potential carcinogenic response.

Purification Methods

Crystallise the phenol from water. [Beilstein 13 IV 803.]

2-Amino-5-nitrophenol Preparation Products And Raw materials

Raw materials

N-Methyl-4-nitroaniline 4-Nitroaniline

Preparation Products

Solvent Red 8 Solvent Red BL Acid Red 215 LEATHERSPRAYINGBLUERL Acid Black 107 Solvent Red KL

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Building Blocks

Oxygen Compounds

Phenols

Organic Building Blocks

Aromatic Phenols

Phenol&Thiophenol&Mercaptan

Phenoles and thiophenoles

Intermediates of Dyes and Pigments

Building Blocks

C6 to C8

Chemical Synthesis

Organic Building Blocks

Oxygen Compounds

Phenols