DIBENZEPINE HCL
- Product Name
- DIBENZEPINE HCL
- CAS No.
- 315-80-0
- Chemical Name
- DIBENZEPINE HCL
- Synonyms
- ecatril;noveril;neodalit;Ansiopax;)diazepin;Dibenzepine;DIBENZEPINE HCL;dibenzepinhydrochloride;hydrofluoride-1927wander;dibenzepinehydrochloride
- CBNumber
- CB5437847
- Molecular Formula
- C18H22ClN3O
- Formula Weight
- 331.84
- MOL File
- 315-80-0.mol
DIBENZEPINE HCL Property
- Melting point:
- 238°
- pka
- 8.25(at 25℃)
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Toxicity
- LD50 orally in mice: 215 mg/kg (Hunziker)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H332Harmful if inhaled
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D416923
- Product name
- DibenzepineHydrochloricAcidSalt
- Packaging
- 25mg
- Price
- $825
- Updated
- 2021/12/16
- Product number
- API0025848
- Product name
- DIBENZEPINE HCL
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $183.75
- Updated
- 2021/12/16
DIBENZEPINE HCL Chemical Properties,Usage,Production
Originator
Noveril ,Wander,Switz.,1965
Uses
Antidepressant.
Definition
ChEBI: Dibenzepin hydrochloride is a dibenzodiazepine.
Manufacturing Process
4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane.
After adding a concentrated benzenic solution of β-dimethylamino-ethyl
chloride freshly prepared from 3.75 grams of the hydrochloride with
concentrated sodium hydroxide solution, taking up in benzene and drying the
solution with potash, the mixture was boiled for 16 hours under reflux,
whereupon the reaction mixture was concentrated to dryness and the residue
distributed between ether and water. By exhaustive extraction of the basic
fractions with dilute acetic acid, precipitation with ammonia, taking up the
base in ether and working up the ethereal solution, there was obtained 5.05
grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11-
dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous
yellowish resin with the boiling point 185°C/0.01mm Hg. The base was
crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of
the monohydrochloride (from ethanol-ether) 234°-240°C.
brand name
Deprex;Ecatrol;Hf 1927;Neodit;Victoril.
Therapeutic Function
Psychostimulant
World Health Organization (WHO)
Dibenzepin hydrochloride, a tricyclic antidepressant, was introduced in 1968 for the treatment of depressive illness. By 1973 its use in Sweden had been associated with an unexpectedly high number of suicide attempts which led to its withdrawal in that country. Although its use has lapsed in several countries, it remains available in at least eight European countries.
DIBENZEPINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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