3-(4-METHOXY-PHENYL)-PROPYLAMINE

3-(4-METHOXY-PHENYL)-PROPYLAMINE Property

Melting point:

65.7-66.5 °C(Solv: water (7732-18-5); methanol (67-56-1))

Boiling point:

118-120 °C(Press: 2 Torr)

Density 

0.992±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

10.32±0.10(Predicted)

Safety

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2922290090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3-(4-METHOXY-PHENYL)-PROPYLAMINE Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of 3-(4-methoxyphenyl)propan-1-amine from the compound (CAS: 583825-29-0) was as follows: synthesis of 3-(4-methoxyphenyl)propanamine (13). Amine 13 was prepared by reacting azide 12 (5.2 g, 0.027 mol) with lithium aluminum hydride (LAH, 26 mL of 1 M THF solution) as described in Method A. The crude product 13 was purified by fast column chromatography (silica gel, eluent ratio 2:1:0.05 chloroform/ethanol/concentrated ammonium hydroxide) to give the pure amine 13 (3.2 g, 74% yield) that It was a transparent oily material. Its 1H NMR (300 MHz, CDCl3) data were as follows: δ 1.58 (m, 2H), 2.50 (m, 4H), 3.72 (s, 3H), 6.85 (d, 2H), 7.0 (d, 2H).

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4098 - 4115
[2] Patent: US2003/195160, 2003, A1
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 27, p. 5362 - 5374
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 20, p. 8441 - 8455