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Diethylamine

Product Name
Diethylamine
CAS No.
109-89-7
Chemical Name
Diethylamine
Synonyms
DEA;Diethylamin;detn;Dietilamina;N-ETHYLETHANAMINE;DIETHYLAMINE FOR SYNTHESIS;ai3-24215;(C2H5)2NH;Diethamine;Diaethylamin
CBNumber
CB5447259
Molecular Formula
C4H11N
Formula Weight
73.14
MOL File
109-89-7.mol
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Diethylamine Property

Melting point:
-50 °C (lit.)
Boiling point:
55 °C (lit.)
Density 
0.707 g/mL at 25 °C (lit.)
vapor density 
2.5 (vs air)
vapor pressure 
14.14 psi ( 55 °C)
refractive index 
n20/D 1.385(lit.)
Flash point:
−20 °F
storage temp. 
Store below +30°C.
solubility 
H2O: soluble1M at 20°C, clear, colorless
form 
Liquid
pka
11.02(at 40℃)
color 
Clear colorless
Odor
Ammoniacal; sharp, fishy.
PH Range
Strong alkaline
Relative polarity
0.145
PH
13 (100g/l, H2O, 20℃)
explosive limit
2.0-11.8%(V)
Odor Type
ammoniacal
Odor Threshold
0.048ppm
Water Solubility 
soluble
Sensitive 
Air Sensitive
Merck 
14,3111
BRN 
605268
Henry's Law Constant
2.56(x 10-5 atm?m3/mol) at 25 °C (Christie and Crisp, 1967)
Exposure limits
NIOSH REL: TWA 10 ppm (30 mg/m3), STEL 25 ppm (75 mg/m3), IDLH 200 ppm; OSHA PEL: TWA 25 ppm; ACGIH TLV: TWA 5 ppm, STEL 15 ppm (adopted).
Dielectric constant
3.7(20℃)
Stability:
Stable. Highly flammable. Incompatible with strong oxidizing agents.
InChIKey
HPNMFZURTQLUMO-UHFFFAOYSA-N
LogP
0.58 at 20℃
CAS DataBase Reference
109-89-7(CAS DataBase Reference)
NIST Chemistry Reference
Ethanamine, N-ethyl-(109-89-7)
EPA Substance Registry System
Diethylamine (109-89-7)
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Safety

Hazard Codes 
F,C
Risk Statements 
11-20/21/22-35
Safety Statements 
16-26-29-36/37/39-45-3
RIDADR 
UN 1154 3/PG 2
WGK Germany 
1
RTECS 
HZ8750000
10-23
Autoignition Temperature
594 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29211990
Hazardous Substances Data
109-89-7(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 540 mg/kg (Smyth)
IDLA
200 ppm
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.03010
Product name
Diethylamine
Purity
for synthesis
Packaging
100mL
Price
$28.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03010
Product name
Diethylamine
Purity
for synthesis
Packaging
500mL
Price
$33.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03010
Product name
Diethylamine
Purity
for synthesis
Packaging
1L
Price
$36.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03010
Product name
Diethylamine
Purity
for synthesis
Packaging
2.5L
Price
$70.9
Updated
2024/03/01
Sigma-Aldrich
Product number
DX1045
Product name
Diethylamine
Packaging
500mL
Price
$209
Updated
2024/03/01
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Diethylamine Chemical Properties,Usage,Production

Description

Diethylamine is a colourless, strongly alkaline, fish odour liquid, and highly inflammable. It has an ammonia-like odour and is completely soluble in water. On burning, diethylamine releases ammonia, carbon monoxide, carbon dioxide, and nitrogen oxides. Diethylamine is used in the production of pesticides. It is used in a mixture for the production of DEET which goes into the repellents that are found readily in supermarkets for general use.

Physical properties

Colorless liquid with a fishy, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 60 μg/m3 (20 ppbv) and 180 μg/m3 (60 ppbv), respectively (Hellman and Small, 1974). Diethylamine is a very strong base in aqueous solution (pKb = 3.0). Its chemistry is governed by the unshared electron pair on the nitrogen, thus it tends to react with acids to form salts.

Occurrence

Diethylamine occurs in low concentrations in food and other biological materials. Concentrations (in p.p.m.) in fresh products include: spinach (15), apples (3), butterbeans (2.4), shelled peas (0.1), bean salad (1.5) and red cabbage (2.4) (HSDB 1989). Pickled vegetables contain 0-3.2 p.p.m. diethylamine while concentrations (in p.p.m.) in other materials include herring (0-5.2), barley (5.7), hops (3.1), boiled beef (2), tobacco leaf (0.1-35) and cigarette smoke concentrate (0-0.4). Interest in the occurrence of diethylamine in foods arises in part because of its possible formation of a carcinogenic N-nitroso derivative (Neurath et al 1977). Diethylamine has been reported in the exhaust from a gasoline engine (Hampton et al 1982).

Uses

Diethylamine is manufactured by heating ethyl chloride and alcoholic ammonia under pressure or by hydrogenation of aziridines in the presence of catalysts. DEA is used as a solvent, as a rubber accelerator, in the organic synthesis of resins, dyes, pesticides, and pharmaceuticals, in electroplating, and as a polymerization inhibitor. Other applications include uses as a corrosion inhibitor. It was reported noneffective as a skin depigmentator.

Production Methods

Diethylamine is produced using the three methods also used for the manufacture of ethylamine with very slight modification.
Diethylamine Synthesis
1. N,N-Diethyl-3-methylbenzamide + Ethylene Glycol + NaOH + Heat
2. Ethylchloride + Ammonia (forms diethylamine HCL)
3. Ethanol + Ammonia + Sulfuric Acid
The most widely used method is the passing of ammonia and ethanol over a catalyst such as alumina or silica (Schweizer et al 1978). Diethylamine can be separated from the mixture by selective distillations and extractions.

Definition

ChEBI: Diethylamine is a secondary aliphatic amine where both N-substituents are ethyl. It is a conjugate base of a diethylammonium.

General Description

A clear colorless liquid with an ammonia-like odor. Density 5.9 lb / gal. Flash point -15°F. A respiratory irritant. Corrosive to the eyes and skin. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

Air & Water Reactions

Highly flammable. Soluble in water. Sensitive to heat. May be sensitive to prolonged exposure to air.

Reactivity Profile

It is incompatible with several chemical substances such as strong oxidisers, acids, cellulose nitrate, some metals, and dicyanofuroxan. N-nitrosamines, many of which are known to be potent carcinogens, may be formed when diethylamine comes in contact with nitrous acid, nitrates, or atmospheres with high nitrous oxide concentrations.

Health Hazard

Diethylamine can be harmful if it is inhaled, swallowed, or in contact with skin. Vapors can irritate the eyes and cause irritation of the respiratory tract, leading to coughing and chest pain. Liquid diethylamine can cause severe burns to the eyes and skin. Vision became misty and halos appeared several hours after workmen were exposed to the vapors of amines such as diethylamine (Grant 1986). The edema of the corneal epithelium, which is principally responsible for the disturbances in vision, clears after one or more days, depending on the severity of exposure. Photophobia and discomfort from roughness of the corneal surface also can occur after greater exposure to the amine.

Flammability and Explosibility

Highly flammable

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No hazardous reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Industrial uses

Diethylamine, like many of the other short chain aliphatic amines, has achieved widespread industrial use as an intermediate in the manufacture of a number of commercial products. Among these are included insecticides, pharmaceuticals, textile finishing agents, and corrosion inhibitors (Hawley 1981; Schweizer et al 1978). It is used as a polymerization inhibitor and/or catalyst in the polymer industry and in the manufacture of surfactants and rubber processing accelerators. This amine also is useful as a depilatory agent for animal skins, as a selective solvent for the removal of impurities from oils, fats, and waxes, and as a flotation agent in the petroleum industry (NIOSH/OSHA 1981; HSDB 1989).

Safety Profile

Moderately toxic by ingestion, inhalation, and skin contact. A skin and severe eye irritant. Exposure to strong vapor can cause severe cough and chest pains. Contact with liquid can damage eyes, possibly permanently; contact with skin causes necrosis and vesciculation. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. Explodes on contact with dicyanofurazan. Violent reaction with sulfuric acid. Ignites on contact with cellulose nitrate of sufficiently high surface area. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

Toxicology

Exposure to low vapor concentrations are reported to transiently impair vision in humans (reduction of sensitivity to light): no-effect threshold 0.022 – 0.028 mL/m3 ( 0.08mg/m3 ). The odor threshold in air is ca. 0.02 – 0.3 mL/m3 ( 0.9 mg/m3 ). Transient physiological effects in rats after 90-d exposure to vapors were reported to already be visible at 0.37 – 4.19 mg/m3 with no effects at 0.05 mg/m3 , but with morphological, apparently reversible changes in the lung and cerebral neurons at the highest concentration. On the other hand, 50 mL/m3 (150 mg/m3 ) was the lowest concentration to show mild, but signifi- cant effects in the lung and liver of rabbits on prolonged inhalation. There were no visible signs of toxicity following exposure of rats to 25 mL/m3 (75 mg/m3 ) for 120 d, but a moderate, bronchiolar hyperplasia of lymphoid cells. It was assumed that diethylamine may exert a certain neurotoxic effect, which, however, was not confirmed by others.

Potential Exposure

Tumorigen,Mutagen. Primary Irritant. Diethylamine (DEA) is used in themanufacture of the following chemicals: diethyldithiocarbamate and thiurams (rubber processing accelerators);diethylaminoethanol (medicinal intermediate); diethylaminopropylamine (epoxy curing agent); N,N-diethyl-m-toluamide and other pesticides; and 2-diethylaminoethylmethacrylate. Itis used in the manufacture of several drugs.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended for 24-48 h afterbreathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor orauthorized paramedic may consider administering a corticosteroid spray.

Carcinogenicity

No evidence of mutagenicity was seen in Ames bacterial assays.8 Diethylamine has an ammonia-like odor that is detectable at 0.13ppm.
The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for diethylamine is 5ppm (15mg/m3) with a short-term excursion limit of 15ppm (45mg/m3) and an A4-not classifiable as a human carcinogen designation; there is a notation for skin absorption.

Environmental Fate

Photolytic. Low et al. (1991) reported that the photooxidation of aqueous secondary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. Diethylamine reacted with NOx in the dark forming diethylnitrosamine. In an outdoor chamber, photooxidation by natural sunlight yielded the following products: diethylnitramine, diethylformamide, diethylacetamide, ethylacetamide, ozone, acetaldehyde, and peroxyacetyl nitrate (Pitts et al., 1978).
Reacts with mineral acids forming water-soluble salts (Morrison and Boyd, 1971).

Metabolism

Little information is available regarding the metabolism of diethylamine. The amine can be readily absorbed from the respiratory and gastrointestinal tract. It has been reported that following oral administration of diethylamine hydrochloride to humans, much of the amine was recovered in the urine (Beard and Noe 1978). This suggests that it is not readily metabolized and, therefore, may not be a substrate for monoamine oxidase. When administered intraperitoneally to rats, it was moderately inhibitory with respect to liver monoamine oxidase (Valiev 1974). Diethylamine may serve as a precursor for the formation of the reportedly carcinogenic N-nitrosoamines and, indeed, when a diethylamine containing liquid was examined for nitrosation reactions under simulated conditions of the human stomach, N-nitrosodiethylamine was formed (Ziebarth 1985).

storage

Diethylamine should be protected from physical damage. It should be kept stored in a cool, dry, well-ventilated location, away from incompatible chemical substances and away from fi re hazard and smoking areas. The containers should be bonded and grounded for transfer to avoid static sparks. Storage and use areas should be no smoking areas.

Shipping

This compound requires a shipping label of“FLAMMABLE LIQUID.” It falls in Hazard Class 3 andPacking Group II.

Purification Methods

Dry diethylamine with LiAlH4 or KOH pellets. Reflux with, and distil it from, BaO or KOH. Convert it to the p-toluenesulfonamide and crystallise to constant melting point from dry pet ether (b 90-120o), then hydrolyse with HCl, excess NaOH is added, and the amine is passed through a column of activated alumina. Redistil the amine and dry it with activated alumina before use [Swift J Am Chem Soc 64 115 1942]. [Beilstein 4 III 313.] § A polystyrene diethylaminomethyl supported version is commercially available.

Incompatibilities

Forms explosive mixture with air. Mayaccumulate static electrical charges, and may cause ignitionof its vapors. Violent reaction with strong oxidizers, strongacids, cellulose nitrate. Incompatible with organic anhydrides, isocyanates, vinyl acetate, acrylates, substitutedallyls, alkylene oxides, epichlorohydrin, ketones, aldehydes,alcohols, glycols, mercury, phenols, cresols, caprolactumsolution. Attacks aluminum, copper, lead, tin, zinc, andalloys.

Precautions

Occupational workers and users should be very careful during the use and chemical management of diethylamine. Workers should wear impervious protective clothing, including boots, gloves, a laboratory coat, apron or coveralls, as appropriate, to prevent skin contact. The chemical is very hazardous, corrosive, and harmful, and is a very flammable liquid and vapor. Exposures to vapor may cause fl ash fi re. It causes burns and adverse effects to the cardiovascular system. Workers should use chemical safety goggles and a full-face shield to avoid splashing of the chemical substance. An eye-wash fountain and quickdrench facilities in the work area should be maintained by the chemical management unit.

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View Lastest Price from Diethylamine manufacturers

Hebei Duling International Trade Co. LTD
Product
Diethylamine 109-89-7
Price
US $6.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2022-10-24
Wuhan Boyuan Import & Export Co., LTD
Product
Diethylamine 109-89-7
Price
US $2.00/mL
Min. Order
1mL
Purity
99%
Supply Ability
50000tons
Release date
2023-05-18
Hebei Yibangte Import and Export Co. , Ltd.
Product
pharmaceutical intermediates Diethylamine 109-89-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2023-11-07

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