ChemicalBook > CAS DataBase List > METHYSTICIN

METHYSTICIN

Product Name: METHYSTICIN
CAS No.: 20697-20-5
Chemical Name: METHYSTICIN
Synonyms: KAVATIN;KAVAHIN;metysticin;METHYSTICIN;(±)-Methysticin;(±)-Methystici);METHYSTICIN USP/EP/BP;Methysticin (DL-Methysticin;5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one;6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
CBNumber: CB5456785
Molecular Formula: C15H14O5
Formula Weight: 274.27
MOL File: 20697-20-5.mol

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METHYSTICIN Property

Melting point:: 129-131 °C
Boiling point:: 496.5±45.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M329360
Product name: DL-Methysticin
Packaging: 5mg
Price: $140
Updated: 2021/12/16

Usbiological

Product number: 300633
Product name: Methysticin
Packaging: 10mg
Price: $490
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259381
Product name: Methysticin
Purity: 98%
Packaging: 20mg
Price: $499.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb105205
Product name: methysticin
Purity: >98%,Standard References Grade
Packaging: 20mg
Price: $569.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003348
Product name: METHYSTICIN
Purity: 95.00%
Packaging: 5MG
Price: $713.26
Updated: 2021/12/16

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METHYSTICIN Chemical Properties,Usage,Production

Uses

DL-Methysticin is a useful synthetic compound.

in vivo

The kavalactone Methysticin (6 mg/kg) is administered once a week for a period of 6 months to 6 month old transgenic APP/Psen1 mice by oral gavage. Methysticin treatment activates the Nrf2 pathway in the hippocampus and cortex of mice. The Aβ deposition in brains of Methysticin-treated APP/Psen1 mice is not altered compared to untreated mice. However, Methysticin treatment significantly reduces microgliosis, astrogliosis and secretion of the pro-inflammatory cytokines TNF-α and IL-17A. Methysticin treatment results in a significant activation of the Nrf2/ARE pathway in hippocampus and the cortex but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice. Methysticin treatment significantly increases the expression of both genes compared to untreated animals^[2].

IC 50

CYP1A1

METHYSTICIN Preparation Products And Raw materials

Raw materials

Preparation Products

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20697-20-5, METHYSTICINRelated Search:

Kavain Limonin DIHYDROMETHYSTICIN METHYSTICIN goniothalamin ((E)-3-METHOXY-HEXA-1,5-DIENYL)-BENZENE 4-phenyl-3-buten-2-ol 5,6-DIHYDRO-2H-PYRAN-2-ONE 3'-hydroxyisosafrole 5,6-DIHYDRO-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE 5,6-DIHYDRO-4-METHOXY-2H-PYRAN METHYSTICIN

5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one

METHYSTICIN

KAVAHIN

KAVATIN

(±)-Methystici)

Methysticin (DL-Methysticin

2H-Pyran-2-one, 6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-

METHYSTICIN USP/EP/BP

metysticin

6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one

(±)-Methysticin

20697-20-5