METHYSTICIN
- Product Name
- METHYSTICIN
- CAS No.
- 20697-20-5
- Chemical Name
- METHYSTICIN
- Synonyms
- KAVATIN;KAVAHIN;metysticin;METHYSTICIN;(±)-Methysticin;(±)-Methystici);METHYSTICIN USP/EP/BP;Methysticin (DL-Methysticin;5,6-Dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-2H-pyran-2-one;6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
- CBNumber
- CB5456785
- Molecular Formula
- C15H14O5
- Formula Weight
- 274.27
- MOL File
- 20697-20-5.mol
METHYSTICIN Property
- Melting point:
- 129-131 °C
- Boiling point:
- 496.5±45.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
N-Bromosuccinimide Price
- Product number
- M329360
- Product name
- DL-Methysticin
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 300633
- Product name
- Methysticin
- Packaging
- 10mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- orb259381
- Product name
- Methysticin
- Purity
- 98%
- Packaging
- 20mg
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- orb105205
- Product name
- methysticin
- Purity
- >98%,Standard References Grade
- Packaging
- 20mg
- Price
- $569.5
- Updated
- 2021/12/16
- Product number
- API0003348
- Product name
- METHYSTICIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $713.26
- Updated
- 2021/12/16
METHYSTICIN Chemical Properties,Usage,Production
Uses
DL-Methysticin is a useful synthetic compound.
in vivo
The kavalactone Methysticin (6 mg/kg) is administered once a week for a period of 6 months to 6 month old transgenic APP/Psen1 mice by oral gavage. Methysticin treatment activates the Nrf2 pathway in the hippocampus and cortex of mice. The Aβ deposition in brains of Methysticin-treated APP/Psen1 mice is not altered compared to untreated mice. However, Methysticin treatment significantly reduces microgliosis, astrogliosis and secretion of the pro-inflammatory cytokines TNF-α and IL-17A. Methysticin treatment results in a significant activation of the Nrf2/ARE pathway in hippocampus and the cortex but not in the midbrain and cerebellum of ARE-luciferase reporter gene mice. Methysticin treatment significantly increases the expression of both genes compared to untreated animals[2].
IC 50
CYP1A1
METHYSTICIN Preparation Products And Raw materials
Raw materials
Preparation Products
METHYSTICIN Suppliers
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- Country
- Germany
- ProdList
- 1136
- Advantage
- 62