ChemicalBook > CAS DataBase List > Musk ketone

Musk ketone

Product Name
Musk ketone
CAS No.
81-14-1
Chemical Name
Musk ketone
Synonyms
KETONE MOSCHUS;(-)-Licarin A;2-Acetyl-5-tert-butyl-4,6-dinitro-1,3-dimethylbenzene;1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-ethanon;MOSCHUS;Ketone musk;MUSK KETONE;Musk ketone 0;MOSCHUS KETON;MUSK KETONE 98+%
CBNumber
CB5458527
Molecular Formula
C14H18N2O5
Formula Weight
294.3
MOL File
81-14-1.mol
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Musk ketone Property

Melting point:
134-137 °C
Boiling point:
436.08°C (rough estimate)
Density 
1.2051 (rough estimate)
vapor pressure 
0.001Pa at 25℃
refractive index 
1.5110 (estimate)
Flash point:
2 °C
storage temp. 
2-8°C
solubility 
DMSO : 250 mg/mL (849.47 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
Odor
at 10.00 % in benzyl benzoate. fatty musk soapy dry floral powdery
Odor Type
musk
Water Solubility 
Insoluble (<0.1 g/100 mL at 20 ºC)
BRN 
2062638
Stability:
Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey
WXCMHFPAUCOJIG-UHFFFAOYSA-N
LogP
4.24 at 25℃
CAS DataBase Reference
81-14-1(CAS DataBase Reference)
NIST Chemistry Reference
2,6-Dimethyl-3,5-dinitro-4-t-butylacetophenone(81-14-1)
EPA Substance Registry System
Musk ketone (81-14-1)
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Safety

Hazard Codes 
F,Xn,N
Risk Statements 
11-20/21/22-36-50/53-40
Safety Statements 
16-36/37-61-60-46
RIDADR 
UN1648 3/PG 2
WGK Germany 
2
RTECS 
KM5775841
HS Code 
2914790060
Hazardous Substances Data
81-14-1(Hazardous Substances Data)
Toxicity
Both the acute oral LD50 in rats and the acute dermal LD50 in rabbits exceeded 10 g/kg (Fogleman, 1970).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H312Harmful in contact with skin

H319Causes serious eye irritation

H332Harmful if inhaled

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
46377
Product name
Musk ketone solution
Purity
100 μg/mL in acetonitrile, analytical standard
Packaging
2ml
Price
$75
Updated
2022/05/15
Sigma-Aldrich
Product number
S342963
Product name
4'-TERT-BUTYL-2',6'-DIMETHYL-3',5'-DINITROACETOPHENONE
Purity
AldrichCPR
Packaging
1g
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
W522902
Product name
Musk ketone
Purity
≥98%
Packaging
sample
Price
$52
Updated
2022/05/15
AK Scientific
Product number
6206AF
Product name
Musk ketone
Packaging
100g
Price
$68
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55046
Product name
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone
Packaging
250g
Price
$80
Updated
2021/12/16
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Musk ketone Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Chemical Properties

It forms yellowish crystals with a sweet, very persistent, slightly animal musk odor.Musk ketone is prepared by Friedel–Crafts acetylation of 1,3-dimethyl-5-tert-butylbenzene and nitration of the resulting 2,6- dimethyl-4-tert-butylacetophenone with nitric acid.
Musk ketone is widely used as a fixative in blossom and fantasy compositions.

Occurrence

Has apparently not been reported to occur in nature.

Uses

Musk ketone is used as fragrance and fixative in after-shave lotions, perfumes, ete.

Definition

ChEBI: 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone is an aromatic ketone.

Preparation

Nitration of the corresponding benzene derivative (Bedoukian, 1967).

General Description

Light yellow crystalline solid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Fire Hazard

Flash point data is not available for Musk ketone, however, Musk ketone is probably combustible.

Flammability and Explosibility

Not classified

Purification Methods

Purify the ketone by recrystallisation from MeOH. It has a strong odour of musk and is used in perfumery. [Fuson et al. J Org Chem 12 587 1947, Beilstein 7 IV 808.]

Musk ketone Preparation Products And Raw materials

Raw materials

1-tert-Butyl-3,5-dimethylbenzene 2-Methyl-1-propanol 4'-tert-Butylacetophenone m-Xylene Zinc chloride Ferric chloride

Preparation Products

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Musk ketone Suppliers

China 234 Europe 4 France 1 Germany 3 India 5 South Korea 1 Switzerland 1 United Kingdom 10 United States 48 USA 1 Global 308
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View Lastest Price from Musk ketone manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Musk ketone 81-14-1
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22
Shandong Deshang Chemical Co., Ltd.
Product
Musk ketone 81-14-1
Price
US $80.00-66.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
10 tons
Release date
2024-06-19
Hebei Kingfiner Technology Development Co.Ltd
Product
Musk ketone 81-14-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2024-06-24

81-14-1, Musk ketoneRelated Search:

N,N-Dimethyldodecylamine tert-Butyl methyl ether Muscone ETHANE Dimethyl ether Musk xylene 3-Nitroacetophenone Dimethyl fumarate L-PICEIN Buprofezin 4-Nitroacetophenone Dimethyl phthalate N,N-Dimethylformamide tert-Butyl hydroperoxide tert-Butyldimethylsilyl chloride Dimethyl sulfoxide Dimethyl sulfide Acetophenone

  • 2-Acetyl-5-tert-butyl-4,6-dinitro-1,3-dimethylbenzene
  • 3',5'-Dinitro-4'-tert-butyl-2',6'-dimethylacetophenone
  • 3, 5-Dinitro-4-t-butyl-2, 6-dimethylacetophenone
  • Ketone Moschus,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Musk ketone
  • Musk ketone,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Ketone Moschus
  • Musk ketone 0
  • Ketone Moschus >=97.0% (N)
  • 1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-ethanon
  • 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-ethanon
  • 1-Acetyl-4-tert-butyl-2,6-dimethyl-3,5-dinitrobenzene
  • 2-acetyl-5-tert-butyl-4,6-dinitroxylene
  • 3,5-Dinitro-2,6-dimethyl-4-tert-butyl acetophenone
  • MUSK KETONE 98+%
  • 4-Aceto-3,5-dimethyl-2,6-dinitro-tert-butylbenzene
  • 2,6-DIMETHYL-3,5-DINITRO-4-TERT-BUTYLACETOPHENONE(MUSKKETONE)
  • 3’,5’-dinitro-2’,6’-dimethyl-4’-tert-butylacetophenone
  • MOSCHUS KETON
  • 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]ethanone
  • 2',6'-Dimethyl-3',5'-dinitro-4'-tert-butylacetophenone
  • 3-METHYLCYCLOPENTADECANONE (D,L-MUSCONE)
  • 4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Ketone Moschus
  • Methylcyclopentadecanone
  • 4’-tert-butyl-2’,6’-dimethyl-3’,5’-dinitro-acetophenon
  • 4’-tert-Butyl-2’,6-dimethyl-3’,5’dmnitroacetophenone
  • 4-t-Butyl-2,6-dimethyl-3,5-dinitroacetophenone
  • 4-tert-Butyl-2,6-dimethyl-3,5-dinitroactophenone
  • Acetophenone, 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitro-
  • Acetyl-dinitro-butyl-xylene
  • Dinitro-tert-butylxylyl methyl ketone
  • Ethanone, 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-
  • Ethanone,1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]-
  • Ketone musk
  • MUSK KETONE
  • MOSCHUS
  • 2,6-DINITRO-3,5-DIMETHYL-4-ACETYL-TERT-BUTYLBENZENE
  • 1-[4-(TERT-BUTYL)-2,6-DIMETHYL-3,5-DINITROPHENYL]ETHAN-1-ONE
  • 1-(4-TERT-BUTYL-2,6-DIMETHYL-3,5-DINITRO-PHENYL)-ETHANONE
  • 4-TERT-BUTYL-3,5-DINITRO-2,6-DIMETHYL ACETOPHENONE
  • 4-TERT-BUTYL-2,6-DIMETHYL-3,5-DINITROACETOPHENONE
  • KETONE MOSCHUS
  • Synthetic Musk ketone
  • Musk ketone Solution in Methanol, 100μg/mL
  • Musk ketone USP/EP/BP
  • Best Price CAS 81-14-1 Musk Ketone Powder
  • (-)-Licarin A
  • Musk ketone in acetonitrile
  • Musk ketone in isooctane
  • Musk ketone 10.0 μg/ml Cyclohexane
  • 81-14-1
  • 81-41-1
  • CH3COC6HC4H9CH3NO22
  • CH3C15H27O
  • CH33CC6NO22CH32COCH3
  • C13 to C14
  • Carbonyl Compounds
  • Building Blocks
  • Ketones
  • Organic Building Blocks