4-(Trifluoromethyl)nicotinonitrile

Product Name: 4-(Trifluoromethyl)nicotinonitrile
CAS No.: 13600-43-6
Chemical Name: 4-(Trifluoromethyl)nicotinonitrile
Synonyms: BUTTPARK 43\57-45;4-(TRIFLUOROMETHYL)NICOTINONITRILE;4-TRIFLUOROMETHYL-3-PYRIDINENITRILE;3-CYANO-4-(TRIFLUOROMETHYL)PYRIDINE;3-Cyano-4-(trifluoromethyl)pyridine95+%;4-(Trifluoromethyl)nicotinonitrile 95+%;4-(trifluoroMethyl)pyridine-3-carbonitrile;4-(Trifluoromethyl)-3-pyridinecarbonitrile;4-(Trifluoromethyl)Nicotinonitrile(WX683324);3-Pyridinecarbonitrile, 4-(trifluoromethyl)-
CBNumber: CB5469325
Molecular Formula: C7H3F3N2
Formula Weight: 172.11
MOL File: 13600-43-6.mol

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4-(Trifluoromethyl)nicotinonitrile Property

Boiling point:: 75-77°C 15mm
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Store at room temperature
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Oil
pka: -0.57±0.18(Predicted)
color: Colourless
InChI: InChI=1S/C7H3F3N2/c8-7(9,10)6-1-2-12-4-5(6)3-11/h1-2,4H
InChIKey: DHIRCRHQLUNYDS-UHFFFAOYSA-N
SMILES: C1=NC=CC(C(F)(F)F)=C1C#N
CAS DataBase Reference: 13600-43-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn,T
Risk Statements: 36/37/38-20/21/22-25
Safety Statements: 26-36-36/37-45
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: C987898
Product name: 3-Cyano-4-(trifluoromethyl)pyridine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 001381
Product name: 3-Cyano-4-(trifluoromethyl)pyridine
Purity: 95%
Packaging: 5g
Price: $279
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-3-X3
Product name: 3-Cyano-4-(trifluoromethyl)pyridine
Purity: 95.0%
Packaging: 10g
Price: $285
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-3-X3
Product name: 3-Cyano-4-(trifluoromethyl)pyridine
Purity: 95.0%
Packaging: 5G
Price: $154
Updated: 2021/12/16

Apolloscientific

Product number: PC2108B
Product name: 4-(Trifluoromethyl)nicotinonitrile
Purity: 95+%
Packaging: 10g
Price: $178
Updated: 2021/12/16

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4-(Trifluoromethyl)nicotinonitrile Chemical Properties,Usage,Production

Chemical Properties

Pale yellow solid

Definition

ChEBI: 4-(Trifluoromethyl)nicotinonitrile is a member of pyridines and a nitrile.

Synthesis

533932-97-7

533932-96-6

13600-43-6

The general procedure for the synthesis of 3-cyano-4-trifluoromethylpyridine (Compound VIIb) from Compound (CAS:533932-97-7) and Compound (CAS:533932-96-6) is as follows (refer to Example 5): Step F: To a solution of 28% sodium methanol (580 mg, 3.0 mmol) in methanol (5 mL) was added a methanol solution of 3-[(4,4,4-trifluoro-3-oxo-1-butenyl)amino]-2-propenenenitrile (a mixture of IIa and IIb; 380 mg, 2.0 mmol), and the reaction mixture was stirred and then refluxed for 2 hours at room temperature. After completion of the reaction, the reaction solution was poured into water and extracted with ethyl acetate. The organic layers were combined, washed with brine, dried over magnesium sulfate and then concentrated. The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate = 3/1) to give 195 mg (56.5% yield) of the target compound 3-cyano-4-trifluoromethylpyridine. 1H-NMR spectrum (200 MHz, CD3OD) δ (ppm): 9.11 (1H, s), 9.03 (1H, d, J=5.1 Hz), 7.72 (1H, d, J=5.1 Hz).

References

[1] Patent: EP1460071, 2004, A1. Location in patent: Page 39
[2] Patent: EP1460071, 2004, A1. Location in patent: Page 40

4-(Trifluoromethyl)nicotinonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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Shaanxi Dideu Medichem Co. Ltd

Product: 4-(Trifluoromethyl)nicotinonitrile 13600-43-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Henan Fengda Chemical Co., Ltd

Product: 4-(Trifluoromethyl)nicotinonitrile 13600-43-6
Price: US $36.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(Trifluoromethyl)nicotinonitrile 13600-43-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

13600-43-6, 4-(Trifluoromethyl)nicotinonitrileRelated Search:

4-(Trifluoromethyl)pyridine (Trifluoromethyl)trimethylsilane 4-Aminobenzotrifluoride Benzotrifluoride 4-(Trifluoromethyl)nicotinic acid 2,6-Lutidine 2,4,6-Collidine 3-Cyanopyridine 2-Methylbenzotrifluoride 4-Methylpyridine 4-Bromobenzotrifluoride Azamethiphos 3-Trifluoromethylpyridine Pyridine Lithium trifluoromethanesulfonate 2-(Trifluoromethyl)pyridine 4-(Trifluoromethyl)benzaldehyde 3-Cyano-4-methylpyridine

BUTTPARK 43\57-45

3-Cyano-4-(trifluoromethyl)pyridine95+%

3-CYANO-4-(TRIFLUOROMETHYL)PYRIDINE

4-TRIFLUOROMETHYL-3-PYRIDINENITRILE

4-(TRIFLUOROMETHYL)NICOTINONITRILE

4-(trifluoroMethyl)pyridine-3-carbonitrile

4-(Trifluoromethyl)Nicotinonitrile(WX683324)

3-Cyano-4-(trifluoromethyl)pyridine, 4-(Trifluoromethyl)pyridine-3-carbonitrile

4-(Trifluoromethyl)nicotinonitrile 95+%

3-CYANO-4-(TRIFLUOROMETHYL) PYRIDINE(NON-HAZARDOUS LABORATORY REAGENTS)

3-Pyridinecarbonitrile, 4-(trifluoromethyl)-

4-(Trifluoromethyl)nicotinonitrile ISO 9001：2015 REACH

4-(Trifluoromethyl)-3-pyridinecarbonitrile

13600-43-6

C7H3F3N2

Pyridines

Pyridine

Boron, Nitrile, Thio,& TM-Cpds

Heterocycles